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Re: Trinellix feel like an SSRI?

Posted by SLS on July 13, 2020, at 16:22:27

In reply to Re: Trinellix feel like an SSRI?, posted by Stargazer2 on July 10, 2020, at 20:38:54

> I am aware of that but at 60 mg the weight gain was more than I was comfortable with if a lower dose would work. So thats my rationale for being on 45 when 60 might work better. Hell 75 or 90 might be better but I could be 50 pounds heavier because of it. My philosophy over 35 years of drug trials is lowest dose, no matter what the literature or insert claim.
> Remember when Prozac 40 was the starting dose. Now many people start at 5 or 10 mg and 10 might be best for them.
> The majority of my drug failures I believe were from starting on too high a dose and overshooting the best dose for me.
>
> I actually cut back to 30 mg alternating with 45 mg in anticipation of a shortage. In one week I started to decompensate. Maybe Ill alternate 45 with 60 and see how I feel doing that.
> Are you worried about a supply shortage?
>


Believe me when I tell you that it is not my goal to take more of anything than I really need. I wouldn't take 60 mg/day if 45 mg/day would work just as well. You would know better than me how much weight gain is dosage-dependent with Nardil. However, I have tried decreasing my dosage of Nardil from 90 mg/day to 75 mg/day. I lost the improvement. Thankfully, I was able to recapture the response once I moved back to 90 mg/day.

I guess it comes down to cost versus benefit. If you have exhausted all other treatment alternatives, you might not conclude so quickly that under-dosing Nardil in order to mitigate weight gain makes sense. Do you have any other treatments lined up?

I would consider combining Wellbutrin with Effexor, Pristiq, or Trintellix. If there is any bipolarity in you or your family, I would also consider taking lamotrigine.


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.

 

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