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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by SueG on July 2, 2000, at 13:54:30
Hi, wondering how I can get hold of reboxetine in Australia. If I have a letter from my prescribing doctor, can it be imported? If so, where exactly could i buy it from? I am new to this. If anyone has any info I'd appreciate your help. Something else i'm interested in that i don't think is available here is Adrafinil.
Thanks in advance.
Sue.
Posted by JohnL on July 4, 2000, at 6:09:04
In reply to Availability of reboxetineAdrafinil in Australia?, posted by SueG on July 2, 2000, at 13:54:30
> Hi, wondering how I can get hold of reboxetine in Australia. If I have a letter from my prescribing doctor, can it be imported? If so, where exactly could i buy it from? I am new to this. If anyone has any info I'd appreciate your help. Something else i'm interested in that i don't think is available here is Adrafinil.
> Thanks in advance.
> Sue.Though both drugs work on the adrenergic chemistries of depression, they do so in very different ways. For example, Reboxetine sent me into a rapid dysphoric depression. Because Adrafinil works on similar chemistries, I didn't expect it would be a good choice. It turned out to be a miracle. They are very different medications. Obviously I personally prefer Adrafinil. :-) More effective with hardly any side effects. Reboxetine could have more pronounced side effects.
JohnL
Posted by SLS on July 4, 2000, at 8:25:38
In reply to Re: Availability of reboxetineAdrafinil in Australia?, posted by JohnL on July 4, 2000, at 6:09:04
> Though both drugs work on the adrenergic chemistries of depression, they do so in very different ways. For example, Reboxetine sent me into a rapid dysphoric depression. Because Adrafinil works on similar chemistries, I didn't expect it would be a good choice. It turned out to be a miracle. They are very different medications. Obviously I personally prefer Adrafinil. :-) More effective with hardly any side effects. Reboxetine could have more pronounced side effects.
> JohnL
I would strenuously like to emphasize that adrafinil does NOT act upon adrenergic alpha-1 receptors. A friend of mine spoke to the inventor of *adrafinil* at a conference several years ago. The inventor stated that he was *sure* that it did not antagonize NE alpha-1 receptors, and that the early work on this drug was wrong.I have not seen any evidence that either modafinil or adrafinil directly affect NE neurotransmission in any way. This might help to explain why you responded so differently to adrafinil versus reboxetine. That you also had a negative response to Wellbutrin, a drug which most researchers believe to exert a pro-adrenergic effect, might support the idea that your response to adrafinil is not NE-mediated.
Why is this important? At this point, I do not believe that inferences should be drawn as to how someone will respond to adrafinil based upon their experiences with noradrenergic drugs and vice-versa.
- Scott
Posted by SLS on July 4, 2000, at 8:32:02
In reply to Re: Availability of reboxetineAdrafinil in Australia? » JohnL, posted by SLS on July 4, 2000, at 8:25:38
In the previous post, I used the word "antagonize" instead of "agonize". Regarding adrafinil, the sentence should read:
The inventor stated that he was *sure* that it did not agonize (stimulate) NE alpha-1 receptors, and that the early work on this drug was wrong.
- Scott
Posted by nhgrandma on July 5, 2000, at 20:13:19
In reply to Re: Availability of reboxetineAdrafinil in Australia?, posted by JohnL on July 4, 2000, at 6:09:04
John L,
I have followed your postings off and on over the last year but I don't have the memory or time to search for answers. Do you take liver tests for the Adrafanil? Is your tinnitus all gone? Does your pdoc know about Adrafanil and approve of it? What are all the meds and doses you are taking? Do you sleep well now? Is your anhedonia gone? If my pdoc says I have anxiety with depression of the bipolar type but not severe enough for a mood stabilizer do you think Adrafanil is worth a try? I currently just take Klonopin for sleep and anxiety. I need energy and to get rid of this anhedonia. Thanks
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