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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 4 of 4. This is the beginning of the thread.
Posted by kmh on June 5, 2001, at 21:43:11
I have been taking 100mg of Topomax and 300mg of Wellbutrin for about two months now. I have noticed that my cycle is out of wack. I had my period for 45 days at first. When that stopped I have more intense cramps through out my cycle. There does not seem to be any down time between when I ovulate to when I start to PMS and then my Period starts again. I really only feel good about 4 days out of the month. Has anyone experienced this with either of these medications?
Posted by SalArmy4me on June 5, 2001, at 22:17:22
In reply to Topomax and Wellbutrin vs Menstrual cycle, posted by kmh on June 5, 2001, at 21:43:11
There is some evidence that suggests that Topiramate has an effect on the reproductive system, more specifically on the efficacy of orally-contraception pills (OCPs): "However, many anticonvulsant medications can induce an increase in hepatic microsomal enzymes, which can produce increased pill metabolism: "The result has been a decrease in the pill’s contraceptive efficacy resulting in an estimated 3.1 pregnancies per 100 women years of use. These medications include carbamazepine, topiramate, and tiagabine. A number of anticonvulsants do not cause such interference, including valproic acid and lamotrigine."
Greydanus, Donald E. MD et al. Contraception in the Adolescent: An Update. Pediatrics. 107(3):562-573, March 2001.I don't know what this means clinically.
Posted by Kaysey on June 5, 2001, at 22:48:38
In reply to Re: Topomax and Wellbutrin vs Menstrual cycle » kmh, posted by SalArmy4me on June 5, 2001, at 22:17:22
> There is some evidence that suggests that Topiramate has an effect on the reproductive system, more specifically on the efficacy of orally-contraception pills (OCPs): "However, many anticonvulsant medications can induce an increase in hepatic microsomal enzymes, which can produce increased pill metabolism: "The result has been a decrease in the pill’s contraceptive efficacy resulting in an estimated 3.1 pregnancies per 100 women years of use. These medications include carbamazepine, topiramate, and tiagabine. A number of anticonvulsants do not cause such interference, including valproic acid and lamotrigine."
> Greydanus, Donald E. MD et al. Contraception in the Adolescent: An Update. Pediatrics. 107(3):562-573, March 2001.
>
> I don't know what this means clinically.Hi! This is my first post, and I feel like I have found my lost world with this group. Although I do not take Topomax (or anti-convulsants, at all), I have been taking Effexor since the last of April (now at 225mg). I also take OCPs and have noticed for two cycles now that I have had a bit of break-through bleeding and a longer and heavier menstrual period. My physical symptoms of PMS (bloating, etc.) are also more pronounced. Though the Effexor has been rather effective mood-wise the remainder of the month, I do have my 'down' days premenstrually. Up until January I had been on LoPresser, ativan and Prozac for GAD and depression for 10 years. These pooped-out (actually along time ago), and my doc changed me to effexor. I never had these menstrual problems while taking these meds--only with the Effexor.
This may not be much help with your Topomax question, but I gather from my post, and others, that cycles can be greatly affected.
Thanks again for the message board!
Posted by Cateb on June 10, 2001, at 9:35:40
In reply to Re: Topomax and Wellbutrin vs Menstrual cycle, posted by Kaysey on June 5, 2001, at 22:48:38
I had regular periods my whole adult life, including a year on combined Zoloft/Wellbutrin. But now that you mentioned it, I added Topamax and have had three irregular (like 9 or 10 days closer together than they should be!) periods within six cycles! I never suspected the Topamax itself...good detective work. I had thought it might be the dramatic weight loss from Topamax, but then I would have thought the periods would just stop completely. In any case, I'm off it now and things have been regular the last two cycles again.
> > There is some evidence that suggests that Topiramate has an effect on the reproductive system, more specifically on the efficacy of orally-contraception pills (OCPs): "However, many anticonvulsant medications can induce an increase in hepatic microsomal enzymes, which can produce increased pill metabolism: "The result has been a decrease in the pill’s contraceptive efficacy resulting in an estimated 3.1 pregnancies per 100 women years of use. These medications include carbamazepine, topiramate, and tiagabine. A number of anticonvulsants do not cause such interference, including valproic acid and lamotrigine."
> > Greydanus, Donald E. MD et al. Contraception in the Adolescent: An Update. Pediatrics. 107(3):562-573, March 2001.
> >
> > I don't know what this means clinically.
>
> Hi! This is my first post, and I feel like I have found my lost world with this group. Although I do not take Topomax (or anti-convulsants, at all), I have been taking Effexor since the last of April (now at 225mg). I also take OCPs and have noticed for two cycles now that I have had a bit of break-through bleeding and a longer and heavier menstrual period. My physical symptoms of PMS (bloating, etc.) are also more pronounced. Though the Effexor has been rather effective mood-wise the remainder of the month, I do have my 'down' days premenstrually. Up until January I had been on LoPresser, ativan and Prozac for GAD and depression for 10 years. These pooped-out (actually along time ago), and my doc changed me to effexor. I never had these menstrual problems while taking these meds--only with the Effexor.
> This may not be much help with your Topomax question, but I gather from my post, and others, that cycles can be greatly affected.
> Thanks again for the message board!
This is the end of the thread.
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