![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 4 of 4. This is the beginning of the thread.
Posted by SalArmy4me on July 10, 2001, at 1:50:04
Archives of General Psychiatry June 2001 (Not from Medline) Efficacy of Estradiol for the Treatment of Depressive Disorders in Perimenopausal Women: A Double-blind, Randomized, Placebo-Controlled Trial.
de Novaes Soares, Claudio MD, PhD. Almeida, Osvaldo P. MD, PhD. Joffe, Hadine MD. Cohen, Lee S. MD.:"The results of this study indicate that estradiol is an effective antidepressant treatment for women in perimenopause. Previous reports had already shown that estrogen replacement therapy improves menopausal somatic symptoms, subjective well-being, and quality of life during perimenopause. 11-12, 25 Recently, in a 6-week study, Schmidt and colleagues 18 found that the use of 50 µg of 17[beta]-estradiol improves mood in perimenopausal women who meet standardized criteria for major and minor depression. Our results support these findings, as estradiol improved mood in subjects with depressive disorders. Estradiol therapy was efficacious in treating depressive symptoms in a larger sample of women who met criteria for MDD (n = 26)—67% of those receiving estradiol had full remission of depression. In addition, we were able to demonstrate the occurrence of continued mood improvement throughout the 12-week treatment phase (decreasing MADRS scores consecutively observed at weeks 4, 8, and 12). Our findings obtained with 100 µg of estradiol contrast with the aforementioned study, 18 which used a lower dose of estradiol, and in which increasing improvement in mood occurred only during the first 3 weeks of treatment."
Posted by anita on July 11, 2001, at 15:01:45
In reply to Estradiol Treatment of Post-Menopausal Depression, posted by SalArmy4me on July 10, 2001, at 1:50:04
Do you know of any studies using estrogen for depression in pre-menopausal women? I may have to go on the pill (in addition to bromocriptine) because since going on risperidone I have not had my periods (hyperprolactinemia), and I've heard that estrogen only, not progesterone, should be used for depressives.
But how much estrogen should be used, and can one just add estrogen w/out progesterone to premenopausal women? I can't find specific treatment guidelines for this anywhere.
Thanks,
anita
> Archives of General Psychiatry June 2001 (Not from Medline) Efficacy of Estradiol for the Treatment of Depressive Disorders in Perimenopausal Women: A Double-blind, Randomized, Placebo-Controlled Trial.
> de Novaes Soares, Claudio MD, PhD. Almeida, Osvaldo P. MD, PhD. Joffe, Hadine MD. Cohen, Lee S. MD.:
>
> "The results of this study indicate that estradiol is an effective antidepressant treatment for women in perimenopause. Previous reports had already shown that estrogen replacement therapy improves menopausal somatic symptoms, subjective well-being, and quality of life during perimenopause. 11-12, 25 Recently, in a 6-week study, Schmidt and colleagues 18 found that the use of 50 µg of 17[beta]-estradiol improves mood in perimenopausal women who meet standardized criteria for major and minor depression. Our results support these findings, as estradiol improved mood in subjects with depressive disorders. Estradiol therapy was efficacious in treating depressive symptoms in a larger sample of women who met criteria for MDD (n = 26)—67% of those receiving estradiol had full remission of depression. In addition, we were able to demonstrate the occurrence of continued mood improvement throughout the 12-week treatment phase (decreasing MADRS scores consecutively observed at weeks 4, 8, and 12). Our findings obtained with 100 µg of estradiol contrast with the aforementioned study, 18 which used a lower dose of estradiol, and in which increasing improvement in mood occurred only during the first 3 weeks of treatment."
Posted by Lorraine on July 12, 2001, at 12:16:55
In reply to Re: Estradiol Treatment of Post-Menopausal Depression, posted by anita on July 11, 2001, at 15:01:45
> > >I may have to go on the pill (in addition to bromocriptine) .
Is the bromocriptine good for your sexual response? (if so, I'll put it in my bag of tricks for sexual dysfunction.)
> > > >since going on risperidone I have not had my periods (hyperprolactinemia), and I've heard that estrogen only, not progesterone, should be used for depressives
Here is the scoop so far as I have been able to determine. Yes, progesterone is considered to be a depressant. With synthetic estrogens (those most commonly prescribed), your estrogen needs to be "opposed" by progesterin to prevent uterine cancer. With natural estrogen---estriol (which you get from a compounding pharmacy) you do not need to oppose with estrogen. Estriol does not provide the same protection against heart attack and osteoporosis that synthetic estrogen does, but it also does not have the association with breast cancer.
Right now, I am on estratest (estrogen and testosterone combined). I have a period every 7 months or so. the estrogen does not help you have periods, the progesterone does that. They say that if you are going to do estrogen and progesterone and are worried about depression that it is best to use a natural progesterone and to take estrogen and progesterone together throughout the month instead of cycling on estrogen for most of the month and then progesterone for the last week or so. Hope this helps. The web site to go to for this info is:
www.womenshealth.com
Lorraine
Posted by SA on August 2, 2001, at 8:55:57
In reply to Re: Estradiol Treatment of Post-Menopausal Depression » anita, posted by Lorraine on July 12, 2001, at 12:16:55
> > > >I may have to go on the pill (in addition to bromocriptine) .
>
> Is the bromocriptine good for your sexual response? (if so, I'll put it in my bag of tricks for sexual dysfunction.)
>
> > > > >since going on risperidone I have not had my periods (hyperprolactinemia), and I've heard that estrogen only, not progesterone, should be used for depressives
>
> Here is the scoop so far as I have been able to determine. Yes, progesterone is considered to be a depressant. With synthetic estrogens (those most commonly prescribed), your estrogen needs to be "opposed" by progesterin to prevent uterine cancer. With natural estrogen---estriol (which you get from a compounding pharmacy) you do not need to oppose with estrogen. Estriol does not provide the same protection against heart attack and osteoporosis that synthetic estrogen does, but it also does not have the association with breast cancer.
>
> Right now, I am on estratest (estrogen and testosterone combined). I have a period every 7 months or so. the estrogen does not help you have periods, the progesterone does that. They say that if you are going to do estrogen and progesterone and are worried about depression that it is best to use a natural progesterone and to take estrogen and progesterone together throughout the month instead of cycling on estrogen for most of the month and then progesterone for the last week or so. Hope this helps. The web site to go to for this info is:
>
> www.womenshealth.com
>
> Lorraine
Lorraine, thank you very much. The natural v synthetic info is helpful. I'll check the Web site you gave.SA
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.