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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by MM on July 20, 2001, at 0:13:33
I didn't take well to SSRI's, but serzone was the best out of the bad I guess. Would remeron be basically the same?
Posted by SalArmy4me on July 20, 2001, at 0:52:47
In reply to What's the difference btwn remeron and serzone?, posted by MM on July 20, 2001, at 0:13:33
Comparison to of Remeron to Serzone:
1. Remeron is more convienient than Serzone because its taken once at bedtime (Serzone is taken BID).
2. Remeron has the potential for increase of libido due to its blockade of the alpha-2 NE receptor, unlike Serzone.
3. Remeron might provide relief from Serzone's nausea due to the blockade of the 5HT-2C receptor.
4. Remeron can be started at a therapeutic dose, unlike Serzone which requires titration for toleration (http://www.preskorn.com/cgi-bin/sp.pl?words=doxepin&wt=be&bl=an&d=/books/omd_s8.html)
5. The risk of pharmacokinetically mediated drug-drug interactions is higher with Serzone due to the inhibition of the drug metabolizing CYP 3A3/4 enzyme; nefazodone has the potential to cause CYP enzyme-mediated drug-drug interactions like fluoxetine, fluvoxamine, and paroxetine. Nefazodone-induced inhibition of CYP 3A3/4 can elevate levels of coprescribed drugs dependent on this CYP enzyme for their oxidative metabolism and that, in turn, can cause untoward consequences: http://www.preskorn.com/columns/9803.html
> I didn't take well to SSRI's, but serzone was the best out of the bad I guess. Would remeron be basically the same?
Posted by Janelle on July 20, 2001, at 1:14:29
In reply to What's the difference btwn remeron and serzone?, posted by MM on July 20, 2001, at 0:13:33
I could be wrong, but I could swear that neither Remeron NOR Serzone are actually officially classified as SSRI's? (someone please correct me if I'm wrong; I'd like to know).
Based on the response just above, it sounds like Remeron would be the "better" of the two, and I'm glad I saw this thread because next appointment with pdoc I was going to ask for Serzone or Remeron. Now I'm leaning more toward Remeron.
Posted by SalArmy4me on July 20, 2001, at 1:31:10
In reply to Re: What's the difference btwn remeron and serzone? » MM, posted by Janelle on July 20, 2001, at 1:14:29
Patient info on Remeron: http://www.vh.org/Patients/IHB/Psych/Medications/mirtaz.html
Posted by MM on July 20, 2001, at 3:37:39
In reply to Remeron » Janelle, posted by SalArmy4me on July 20, 2001, at 1:31:10
Ya you're right Janelle, Serzone is an SNRI (norepinephrine?). That probably has something to do with why I liked it more than the SSRI's.
Posted by mdertinger on January 3, 2002, at 12:21:59
In reply to Re: What's the difference btwn remeron and serzone? » MM, posted by SalArmy4me on July 20, 2001, at 0:52:47
You forgot to mention that a side effect of Remeron is weight gain and increased appetite.
> Comparison to of Remeron to Serzone:
>
> 1. Remeron is more convienient than Serzone because its taken once at bedtime (Serzone is taken BID).
>
> 2. Remeron has the potential for increase of libido due to its blockade of the alpha-2 NE receptor, unlike Serzone.
>
> 3. Remeron might provide relief from Serzone's nausea due to the blockade of the 5HT-2C receptor.
>
> 4. Remeron can be started at a therapeutic dose, unlike Serzone which requires titration for toleration (http://www.preskorn.com/cgi-bin/sp.pl?words=doxepin&wt=be&bl=an&d=/books/omd_s8.html)
>
> 5. The risk of pharmacokinetically mediated drug-drug interactions is higher with Serzone due to the inhibition of the drug metabolizing CYP 3A3/4 enzyme; nefazodone has the potential to cause CYP enzyme-mediated drug-drug interactions like fluoxetine, fluvoxamine, and paroxetine. Nefazodone-induced inhibition of CYP 3A3/4 can elevate levels of coprescribed drugs dependent on this CYP enzyme for their oxidative metabolism and that, in turn, can cause untoward consequences: http://www.preskorn.com/columns/9803.html
>
> > I didn't take well to SSRI's, but serzone was the best out of the bad I guess. Would remeron be basically the same?
Posted by BarbaraCat on January 5, 2002, at 23:54:16
In reply to Re: What's the difference btwn remeron and serzone?, posted by mdertinger on January 3, 2002, at 12:21:59
I tried Serzone (and every other SSRI, SSxxx out there). Serzone had me feeling like a zombie for over a week and didn't have any appreciable effect on my depression. Remeron did not have the sedating effect and has worked better than any other AD I have used. Simply beautiful, everyday normal contentment and well-being. And then after 2 months, the poop-out. I'm now on 45 mg, up from 30 and augmenting with lithium. What a dissapointment.
This is the end of the thread.
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