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Dr. Bob is Robert Hsiung, MD,
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Posted by paul w on August 11, 2001, at 5:01:02
Folks
my doc wishes to add 50mg Traz to my existing 40mg of Paxil, given that I've barely responded in 6 weeks.Day time sedation and mental fog is already a problem and emerging from the pit in a morning is a ferocious battle. Limited research suggests that this combo could exacerbate the situation?
Anybody have any joyful thoughts or experiences for me to ponder over?
Thank you very much
Paul
Posted by SalArmy4me on August 11, 2001, at 9:00:26
In reply to Trazadone augment. w/Paxil?, posted by paul w on August 11, 2001, at 5:01:02
Trazodone and lack of side-effects:
Hertzberg, Michael A. MD et al. "Trial of Trazodone for Posttraumatic Stress Disorder Using a Multiple Baseline Group Design." Journal of Clin. Psychopharmacology. 16(4):294-298, Aug 96:
"...Thereafter, as long as side effects remained insignificant, the dosage was increased 100 mg monthly to 400 mg at 3 months. This very gradual dosing schedule was chosen in order to reduce the development of intolerable side effects. If side effects were significant (e.g., hypersomnolence), dosing was altered. If the therapeutic dose was achieved before 400 mg as determined by the treating physician, no further increases were made. The mean therapeutic dose was 300 mg (range 150-400 mg). All medication was taken at one dose before bedtime. Medication side effects were rated by means of a 34-item checklist, which was presented to the patient at baseline and then repeated at each visit. Only one of the six subjects reported a significant side effect (rash in 3rd treatment month), but was then titrated at a slower pace across the treatment period with no further occurrence of rash..."
Posted by Bill L on August 13, 2001, at 9:07:30
In reply to Trazadone augment. w/Paxil?, posted by paul w on August 11, 2001, at 5:01:02
Maybe the doc thinks that you are having trouble sleeping and that is why you have daytime drowsiness.
Six weeks is not necessarily a long enough trial for Paxil. Give it another 4 to 6 weeks to see if you get more improvement.
Maybe you could take the Paxil before going to sleep so you will wake up feeling better.
> Folks
> my doc wishes to add 50mg Traz to my existing 40mg of Paxil, given that I've barely responded in 6 weeks.
>
> Day time sedation and mental fog is already a problem and emerging from the pit in a morning is a ferocious battle. Limited research suggests that this combo could exacerbate the situation?
>
> Anybody have any joyful thoughts or experiences for me to ponder over?
>
> Thank you very much
>
> Paul
This is the end of the thread.
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