![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 13 of 13. This is the beginning of the thread.
Posted by davidh on November 23, 2001, at 19:47:21
Any idea when it will come on the market in the US? Is it available in any other country right now?
Thanks,
David
Posted by Sunnely on November 23, 2001, at 23:34:55
In reply to Escitalopram, posted by davidh on November 23, 2001, at 19:47:21
> Any idea when it will come on the market in the US? Is it available in any other country right now?
>
> Thanks,
> DavidForest Labs conducted clinical trials on escitalopram and submitted a new drug application (NDA) to the U.S. Food and Drug Administration (FDA) that seeks a depression therapy indication for the new compound. Approval could come by the first quarter of 2002, possibly sooner.
Posted by bonnie_ann on November 24, 2001, at 21:17:19
In reply to Re: Escitalopram » davidh, posted by Sunnely on November 23, 2001, at 23:34:55
> > Any idea when it will come on the market in the US? Is it available in any other country right now?
> >
> > Thanks,
> > David
>
> Forest Labs conducted clinical trials on escitalopram and submitted a new drug application (NDA) to the U.S. Food and Drug Administration (FDA) that seeks a depression therapy indication for the new compound. Approval could come by the first quarter of 2002, possibly sooner.I looked up Forest's ticker symbol FRX and read that they are looking more towards June to launch.
I hope it's sooner.
B
Posted by davidh on November 25, 2001, at 14:32:29
In reply to Re: Escitalopram » davidh, posted by Sunnely on November 23, 2001, at 23:34:55
> Forest Labs conducted clinical trials on escitalopram and submitted a new drug application (NDA) to the U.S. Food and Drug Administration (FDA) that seeks a depression therapy indication for the new compound. Approval could come by the first quarter of 2002, possibly sooner.
Any idea if it is available in Europe?
Posted by nightlight on November 25, 2001, at 15:15:45
In reply to Escitalopram, posted by davidh on November 23, 2001, at 19:47:21
To any & all,
What type of drug is this?
Just curious...nightlight
> Any idea when it will come on the market in the US? Is it available in any other country right now?
>
> Thanks,
> David
Posted by Phil on November 25, 2001, at 16:58:50
In reply to Re: Escitalopram, posted by nightlight on November 25, 2001, at 15:15:45
Andrew Soloman, the author of Noonday Demon, disclosed that his father was or is an executive of Forest Labs.
Hmmm....
Phil
Posted by Cam W. on November 25, 2001, at 19:15:02
In reply to Re: Escitalopram, posted by nightlight on November 25, 2001, at 15:15:45
Nightlight - Escitalopram is the "S" isomer of citalopram (Celexa) which is the more active isomer of this antidepressant (ie. the isomer that has much more antidepressant activity). The citalopram isomers (R and S) are mirror images of each other, and Celexa is a mixture of the R and S isomers. Theoretically, escitalopram will be a more potent version of Celexa).
Since Forest will soon lose it's exclusivity of citalopram (ie. generic companies will be able to make and sell their own version), this is a way of extending the patent of their drug.
- Cam
Posted by nightlight on November 26, 2001, at 6:48:09
In reply to Re: Escitalopram » nightlight, posted by Cam W. on November 25, 2001, at 19:15:02
Hi Cam~
Thanks for the info. Interestingly (to me, anyway) Celexa was the only A-D I ever tried out that gave me absolutely no 'start-up' effects or on-going side-effects whatsoever. It also did not affect my mood/depression/activity level one jot! I took it a couple of months, but, nada.
I didn't know it had been around long enuf for its patent to expire. Isn't that about 15 yrs.?Thanks again~
nightlight
> Nightlight - Escitalopram is the "S" isomer of citalopram (Celexa) which is the more active isomer of this antidepressant (ie. the isomer that has much more antidepressant activity). The citalopram isomers (R and S) are mirror images of each other, and Celexa is a mixture of the R and S isomers. Theoretically, escitalopram will be a more potent version of Celexa).
>
> Since Forest will soon lose it's exclusivity of citalopram (ie. generic companies will be able to make and sell their own version), this is a way of extending the patent of their drug.
>
> - Cam
Posted by Cam W. on November 26, 2001, at 8:03:51
In reply to Re: Escitalopram, posted by nightlight on November 26, 2001, at 6:48:09
Nightlight - < LOL > - I guess it can be said, Effexor... a drug that needs to be respected; is highly efficacious in most people.... Celexa... a very safe drug in most respects; doesn't work, but it is a very safe drug. - Cam
Posted by Adam on November 26, 2001, at 9:26:34
In reply to Re: Escitalopram » nightlight, posted by Cam W. on November 25, 2001, at 19:15:02
The same approach has been taken with fluoxetine: Rather than sell a racemite, sell the active (or most active) enantiomer.
I'm not sure about citalopram, but in the case of fluoxetine, it is thought that its stereoisomers are not only different for 5-HT-reuptake inhibition, they may be different for some other properties (receptor agonism, perhaps). Most interestingly, this refinement of the drug is thus thought to reduce some side effects, and that is part of the patent-extension and marketing angle. The irony is, some of these alleged "side effects" have gotten Eli Lily sued, and Lily did their damnedest before to defend themselves against liability by claiming they didn't exist.
> Nightlight - Escitalopram is the "S" isomer of citalopram (Celexa) which is the more active isomer of this antidepressant (ie. the isomer that has much more antidepressant activity). The citalopram isomers (R and S) are mirror images of each other, and Celexa is a mixture of the R and S isomers. Theoretically, escitalopram will be a more potent version of Celexa).
>
> Since Forest will soon lose it's exclusivity of citalopram (ie. generic companies will be able to make and sell their own version), this is a way of extending the patent of their drug.
>
> - Cam
Posted by nightlight on November 26, 2001, at 19:42:18
In reply to Re: Escitalopram » nightlight, posted by Cam W. on November 26, 2001, at 8:03:51
> Nightlight - < LOL > - I guess it can be said, Effexor... a drug that needs to be respected; is highly efficacious in most people.... Celexa... a very safe drug in most respects; doesn't work, but it is a very safe drug. - Cam
~giggle~
Maybe so Cam...Effexor put me to sleep 16 hours a day for 3 weeks before I had to drop it. I tried it during the holidays 2 yrs. ago~brilliant idea! When I titrated off (I only got up to 75mgs) I then spiralled into my 2nd worst depression ever. It was a few months before I wd. put another A-D in my system again. But, I did get back on the horse for a few more experimental rides thru A-D land ...
nightlight
Posted by Simcha on November 27, 2001, at 7:27:54
In reply to Re: Escitalopram » nightlight, posted by Cam W. on November 26, 2001, at 8:03:51
Cam,
Hey! ;-) LOL!
Just because Celexa does not work for your chemistry does not mean it won't work for someone else.
Trust me, Celexa has been a life-saver. I know that it is working because I tried cutting the dose in half (under pdoc supervision) and I became positively loopy. I'm back up to the 40mg dose and I'm stable for the first time in quite a while.
EffexorXR should be respected. It worked for me on my depression (but not the OCD or anxiety). It also left me absolutely numb from the waist down. I was on it for a good 5 months so I had a more than adequate trial with it. The side effects for me were depressing and it was difficult not having help with the OCD or anxiety. So Effexor is not the "majic bullet" for everyone, O wise one. ;-)
Take Care,
Simcha> Nightlight - < LOL > - I guess it can be said, Effexor... a drug that needs to be respected; is highly efficacious in most people.... Celexa... a very safe drug in most respects; doesn't work, but it is a very safe drug. - Cam
Posted by Cam W. on November 28, 2001, at 0:10:41
In reply to Re: Escitalopram » Cam W., posted by Simcha on November 27, 2001, at 7:27:54
Simcha - Yeah, I know I was overgenralizing, again. I know quite a few people who have been helped by Celexa, but I know more who haven't. Some day we will be able to do genetic phenotyping to taylor drugs to our specific make-ups. That will be cool.
- Cam
> Cam,
>
> Hey! ;-) LOL!
>
> Just because Celexa does not work for your chemistry does not mean it won't work for someone else.
>
> Trust me, Celexa has been a life-saver. I know that it is working because I tried cutting the dose in half (under pdoc supervision) and I became positively loopy. I'm back up to the 40mg dose and I'm stable for the first time in quite a while.
>
> EffexorXR should be respected. It worked for me on my depression (but not the OCD or anxiety). It also left me absolutely numb from the waist down. I was on it for a good 5 months so I had a more than adequate trial with it. The side effects for me were depressing and it was difficult not having help with the OCD or anxiety. So Effexor is not the "majic bullet" for everyone, O wise one. ;-)
>
> Take Care,
> Simcha
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.