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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 8 of 8. This is the beginning of the thread.
Posted by geno on March 31, 2002, at 18:39:03
I have a few comments and questions. Im visiting my poc this week and want to change meds.Note i suffer from ptsd, depression, lethargy, anxiety, and social phobia. This steems from yrs of ghb and ephedrine and alcohol abuse.
Im searching for a good med combo, for months now, to replace above such. My current meds are:
Remeron 30mg (sleep disorder)
Klonopin 1mg Am.
Paxil 10mg depression
desipramine 25mg low anxiety stimulantThis combo is ok, but im sill slighly depressed, social phobic and non talkative, anxiety is quelled ok.
I want to try zoloft, more klonopin, and dexadrine.
Does any feel this will greatly improve my problems.
Oh also ambien for sleep. The remeron may be sedating my brain too much.geno
Posted by jay on March 31, 2002, at 19:29:47
In reply to Social Phobia MEDS , posted by geno on March 31, 2002, at 18:39:03
Geno:Is it possible to try one of the new atypical antipsychotics? I know they scare a lot of people, but these things really seem to be a 'powerhouse' when added to an already good med combo. It also doesn't mean you have to take them forever. You can get very, very low doses of these things, and it was my family doc, not psychiatrist, who suggested it. I have seen some great success with both Risperdal and Zyprexa.
A couple of other thoughts. With say a good low dose, and long lasting ap like Zyprexa, you could maybe greatly lower your dose of Remeron. Along with that, I would also say spread out the klonipin, and take it in am and pm. I also think a slightly higher dose of klonipin prn may be helpful.
What do you think? I would say the low dose Zyprexa may help even out your dopamine system that may have been disrupted by either heavy GHB and Ephedra use.
I'd be a bit cautious with the Dexedrine use, but that is going to have to be for you to decide.(Have you tried Welbutrin? It has many stimulant-like properties, without the 'crash' or 'poop-out' of stims.) The only problem I would have with Dexedrine is it's anxiety-increasing potential. In other words...go low and slow.
P.S. I might also suggest, if you can, get a second prescription for Xanax a few times a day until you feel stable, then you can maybe phase out or lower it. The *important* part is to get stability.
Best wishes..
Jay
> I have a few comments and questions. Im visiting my poc this week and want to change meds.Note i suffer from ptsd, depression, lethargy, anxiety, and social phobia. This steems from yrs of ghb and ephedrine and alcohol abuse.
> Im searching for a good med combo, for months now, to replace above such. My current meds are:
> Remeron 30mg (sleep disorder)
> Klonopin 1mg Am.
> Paxil 10mg depression
> desipramine 25mg low anxiety stimulant
>
> This combo is ok, but im sill slighly depressed, social phobic and non talkative, anxiety is quelled ok.
>
> I want to try zoloft, more klonopin, and dexadrine.
> Does any feel this will greatly improve my problems.
> Oh also ambien for sleep. The remeron may be sedating my brain too much.
>
> geno
Posted by geno on March 31, 2002, at 20:04:33
In reply to Re: Social Phobia MEDS » geno, posted by jay on March 31, 2002, at 19:29:47
What im thinking is this. GHB temporarily blocks dopamine. This is where possibly a low dose of an anitphycotic will come it.
Second ghb binds gaba reception. This where klonopin or xanax comes in.
Third, ghb increases 'seratonin turnover rate'. This is where zoloft comes in.Maybe seroquel/zyprexa mixed with klonopin and zoloft will help. If i feel to sedated, hit me off with some dexadrine.
hope this helps .
geno
Posted by JohnX2 on April 1, 2002, at 4:51:45
In reply to Re: Social Phobia MEDS, posted by geno on March 31, 2002, at 20:04:33
> What im thinking is this. GHB temporarily blocks dopamine. This is where possibly a low dose of an anitphycotic will come it.
> Second ghb binds gaba reception. This where klonopin or xanax comes in.
> Third, ghb increases 'seratonin turnover rate'. This is where zoloft comes in.
>
> Maybe seroquel/zyprexa mixed with klonopin and zoloft will help. If i feel to sedated, hit me off with some dexadrine.
>
> hope this helps .
> genoKlonopin inhibits the serotonin turnover rate.
John
Posted by JohnX2 on April 1, 2002, at 4:55:21
In reply to Re: Social Phobia MEDS » geno, posted by JohnX2 on April 1, 2002, at 4:51:45
> > What im thinking is this. GHB temporarily blocks dopamine. This is where possibly a low dose of an anitphycotic will come it.
> > Second ghb binds gaba reception. This where klonopin or xanax comes in.
> > Third, ghb increases 'seratonin turnover rate'. This is where zoloft comes in.
> >
> > Maybe seroquel/zyprexa mixed with klonopin and zoloft will help. If i feel to sedated, hit me off with some dexadrine.
> >
> > hope this helps .
> > geno
>
> Klonopin inhibits the serotonin turnover rate.
>
> JohnKlonopin binds to the GabaA receptor. I believe in another post you indicated GHB was a GabaB substance.
John
Posted by JohnX2 on April 1, 2002, at 5:00:14
In reply to Social Phobia MEDS , posted by geno on March 31, 2002, at 18:39:03
Geno,Do you get jaw tension or grind your teeth from GHB use?
John
Posted by geno on April 1, 2002, at 9:10:44
In reply to Re: q? » geno, posted by JohnX2 on April 1, 2002, at 5:00:14
John, i actually dont use ghb. I use gbl. Its the chemcial percursor to ghb. Yes its still addictive or even more as ghb. It hits you quicker, like doing a shot, opposed to a beer.
GHB is still very misunderstood. Claud Raffit, a french scientist (very smart man) did expensive studies on ghb in europe along with Dr. hendry Laborit. Ward Dean, author of the book ghb, the nautural mood enhancer, got most of his info from these guys.
I call ghb the most wonderful/evil sustance. Why? because for me and most addicts, there is nothing out there, no drug, illegal or legal, that makes you happy and outgoing as ghb. Like i mean i could be ready to commit suicide or catch my wife (if i had one) with another guy, take a dose and 20min later, be happy! no ifs ands or buts.
Yes if you over due your dose, it can cause all types of side effects, from twiching, ghb lowers siezure threashold due to dopamine function. Jaw tention and teeth grinding sometimes happens. But Claud raffit advised to take a low dose of clonazipam .5-1mg to negate the side effects and it works, do to its aniconvusant properties and highering of the seizure threshold. I take .5mg when i use ghb. 1mg is a big to high and sedation overrules.Yes ghb enhances binding of gaba-b chloride channels. Yes arent they similar causing the antianxiety effect?
The bad thing about ghb is the steep response curve. 2g makes you fine 3 may cause you to fall asleep. Never mix with alchol, i found out the hard way after smashing cars and ging out all over the place. maybe 1 or 2 beers TOPS. But alchol makes me so depressed, its not funny. Esp with all the meds i take, it somehow interacts and i feel like hell.
I coming to a conlusion, the lower of dopamine by ghb, along with gaba b enhancement binding, causes the antianxiety antiparinoia effect.
By the way, define seratonin turnover? does this mean more seratonin is released into the synapse?
thanks
geno
Posted by Ritch on April 1, 2002, at 9:40:55
In reply to Social Phobia MEDS , posted by geno on March 31, 2002, at 18:39:03
> I have a few comments and questions. Im visiting my poc this week and want to change meds.Note i suffer from ptsd, depression, lethargy, anxiety, and social phobia. This steems from yrs of ghb and ephedrine and alcohol abuse.
> Im searching for a good med combo, for months now, to replace above such. My current meds are:
> Remeron 30mg (sleep disorder)
> Klonopin 1mg Am.
> Paxil 10mg depression
> desipramine 25mg low anxiety stimulant
>
> This combo is ok, but im sill slighly depressed, social phobic and non talkative, anxiety is quelled ok.
>
> I want to try zoloft, more klonopin, and dexadrine.
> Does any feel this will greatly improve my problems.
> Oh also ambien for sleep. The remeron may be sedating my brain too much.
>
> genoGeno,
I would consider ditching the Paxil *and* the desipramine and try Zoloft (25mg). It may be more effective for your ptsd. Desipramine worsened anxiety for me. Zoloft was the most *motivating* SSRI of the bunch for me (just can't tolerate the GI sfx). It blocks reuptake of DA more than the others. I had more sleep trouble on Zoloft than the others though. In that case you might be able to *lower* your Remeron down to 15mg and sleep better. Just some ideas,
Mitch
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