Psycho-Babble Medication Thread 208638

Shown: posts 1 to 4 of 4. This is the beginning of the thread.

 

Remeron, question about high dosages

Posted by Rainbowlight on March 13, 2003, at 0:31:02

I have recently began taking 45 mgs. Remeron, instead of my usual 30 mgs. I have restarted the med after being off it for 2 months. I have noticed I feel wired (like over caffeinated) and am not sleeping very well. I have been at this new dose for 2 weeks now. I am wondering if it is just too much for me? or is this the way the med changes once you get to the higher dosages? My pdoc upped the dose in hopes it would help with the weight gain issues I have had with this med (30 pound weight gain).

 

Re: Remeron, question about high dosages

Posted by Caleb462 on March 13, 2003, at 3:34:59

In reply to Remeron, question about high dosages, posted by Rainbowlight on March 13, 2003, at 0:31:02

> I have been at this new dose for 2 weeks now. I am wondering if it is just too much for me? or is this the way the med changes once you get to the higher dosages?

Yes, this is the way the med changes. Remeron is usually considered sedating at low doses, and activating at high doses. This results from histamine antagonism at low doses, but norepinephrine reuptake inhibition at high doses.

 

Re: Remeron, question about high dosages

Posted by Shawn. T. on March 13, 2003, at 16:19:44

In reply to Re: Remeron, question about high dosages, posted by Caleb462 on March 13, 2003, at 3:34:59

Remeron doesn't inhibit norepinephrine reuptake at high doses; its activity as a norepinephrine alpha-2 receptor antagonist increases. Alpha-2 receptors act as norepinephrine autoreceptors; that means that when certain alpha-2 receptors are activated, they decrease the release of norepinephrine. Remeron blocks these receptors, and it increases extracellular norepinephrine to greater degrees as the dosage taken increases. The increased extracellular norepinephrine activates beta2/beta3-adrenoceptors; this is the same mechanism through which caffeine indirectly causes weight loss.

Shawn

 

Re: Remeron, question about high dosages

Posted by Caleb462 on March 13, 2003, at 22:53:30

In reply to Re: Remeron, question about high dosages, posted by Shawn. T. on March 13, 2003, at 16:19:44

> Remeron doesn't inhibit norepinephrine reuptake at high doses; its activity as a norepinephrine alpha-2 receptor antagonist increases. Alpha-2 receptors act as norepinephrine autoreceptors; that means that when certain alpha-2 receptors are activated, they decrease the release of norepinephrine. Remeron blocks these receptors, and it increases extracellular norepinephrine to greater degrees as the dosage taken increases. The increased extracellular norepinephrine activates beta2/beta3-adrenoceptors; this is the same mechanism through which caffeine indirectly causes weight loss.
>
> Shawn


Ohhhh yeah, that's right. My mistake, sorry.


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