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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 4 of 4. This is the beginning of the thread.
Posted by jparsell82 on September 24, 2003, at 17:57:11
I came across the following articles:
"The antidepressive efficacy of 1-deprenyl (5-10 mg daily) plus 1-phenylalanine (250 mg/day) has been evaluated in 155 unipolar depressed patients. Both oral and intravenous administration showed beneficial effects in 90% of outpatients and 80.5% of inpatients. It is concluded that this combined treatment has a potent antidepressive action based on the accumulation of 1-phenylethylamine in the brain."
"Deprenyl when combined with phenylalanine treatment is found to be very effective at relieving depression. Phenylalanine is an amino acid that acts as a precursor to neurotransmitters when taken on an empty stomach along with Vitamin B6 and Vitamin C in the Perfect Balance Formula to help nerve uptake in the brain. The clinical efficacy of deprenyl (5-10mg) plus phenylalanine (250mg) per day for depression was equaled only by the electroconvulsive treatments (ECT)---without the memory- loss side effect of ECT. However, there are side effects associated with deprenyl plus phenylalanine in some people, such as sleeplessness, anxiety, and tension. These side effects could probably be eliminated by decreasing the dose of phenylalanine, or adding a serotonergic precursor like tryptophan)."
I've been wanting to take Klonopin & a stimulant for my ADD/SocialPhobia/OCD but haven't been able to get my doc to prescribe both. I'm thinking about trying Klonopin and Deprenyl+Phenylalanine. Deprenyl has a lot of good effects and Phenylalanine with it would really stimulant your mind with all the dopamine. Anyone tried this combo??
Posted by DSCH on September 26, 2003, at 14:24:01
In reply to Deprenyl + Phenylalnine for Depression, etc., posted by jparsell82 on September 24, 2003, at 17:57:11
There was a... *ahem*... enthusiast ;-) for this approach who posted to the board quite a bit about it some time ago. Username was 'rocket_boy'. In theory it does seem like a pretty good idea, however...
I doubt if your pdoc will like the idea very much. It's counting very much on selegiline acting like a RIMA *in your case* at low dose. As this has not gone beyond small trials (IIRC) who's to say this would be the case for everyone? *If* it is acting as a MAOI rather than a RIMA then you would be in danger of tyramine crisis or interactions with such things as cold/allergy medications which you wouldn't be actively on the lookout to prevent.
It's asking for the pdoc to go off-label too. IIRC selegiline is only FDA-approved for Parkinson's.
Posted by jparsell82 on September 27, 2003, at 12:25:05
In reply to Re: Deprenyl + Phenylalnine for Depression, etc. » jparsell82, posted by DSCH on September 26, 2003, at 14:24:01
Well actually, I will Deprenyl from Europe. I'm not even going to try to ask my doc. The tyramine effect doesn't take effect with Selegilene until atleast 15-20 mg a day or more. Below 15mg Selegilene is selective for MAO-B only. Anyways, I'll find out soon.
Posted by DSCH on September 27, 2003, at 17:47:49
In reply to Re: Deprenyl + Phenylalnine for Depression, etc., posted by jparsell82 on September 27, 2003, at 12:25:05
> Well actually, I will Deprenyl from Europe. I'm not even going to try to ask my doc. The tyramine effect doesn't take effect with Selegilene until atleast 15-20 mg a day or more. Below 15mg Selegilene is selective for MAO-B only. Anyways, I'll find out soon.
Ah, MAO-B rather than MAO-A, so it's not really a RIMA rather than an MAOI at low dose.
You appear to have done some research and are well set on this course of action. Please be careful. I would start at the lowest possible dose and gradually work up from there in small increments. It would also be wise to always have on hand during the trial period the antidote to tyramine crisis (I cannot recall what drug it is right now) just in case your dosage rises into the MAOI regime (remember this could concievably vary from person to person).
This is the end of the thread.
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