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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by nicky847 on January 5, 2004, at 9:52:56
I read a fascinating article in the 1/2/04 edition of the Wall Street Journal regarding favorable results from tests done in using MRIs to treat bipolar disorder. In test subjects those that received MRIs reported improvement at a rate twice that of those that received placebo. The article said this could be a breakthrough and that in a few years doctors could be able to use this as a fast acting treatment for depression and bipolar disorder..the article even said that a machine could be developed that allows patients to perform the procedure in their home!
Did anyone else read this article? I find this very exciting!
Posted by Larry Hoover on January 5, 2004, at 10:04:11
In reply to MRIs as treatment for bipolar disorder?, posted by nicky847 on January 5, 2004, at 9:52:56
> I read a fascinating article in the 1/2/04 edition of the Wall Street Journal regarding favorable results from tests done in using MRIs to treat bipolar disorder. In test subjects those that received MRIs reported improvement at a rate twice that of those that received placebo. The article said this could be a breakthrough and that in a few years doctors could be able to use this as a fast acting treatment for depression and bipolar disorder..the article even said that a machine could be developed that allows patients to perform the procedure in their home!
>
> Did anyone else read this article? I find this very exciting!I read an article, probably a wire service thing that gets used as filler on the science pages.....maybe the same article.
It was a serendipitous finding (i.e. they were looking for something else), but subjects who had an unusual form of MRI applied to them reported immediate improvement in how they felt. There's a lot to be learned about just what sort of field is required for the outcome, how long it lasts, etc....but, the good news is that a home treatment device (if it is developed), requires only the MR of MRI.
Magnetic resonance is responsible for the observed effect. It is the imaging part that makes MRI equipment so expensive and bulky.
Lar
Posted by Jaynee on January 5, 2004, at 11:43:58
In reply to MRIs as treatment for bipolar disorder?, posted by nicky847 on January 5, 2004, at 9:52:56
http://www.sciencedaily.com/releases/2004/01/040101091614.htm
Posted by Ron Hill on January 5, 2004, at 13:57:21
In reply to I posted this earlier, here is the link........., posted by Jaynee on January 5, 2004, at 11:43:58
> http://www.sciencedaily.com/releases/2004/01/040101091614.htm
Scott,
I want you to try this. Find out what you need to do to be part of the upcoming larger trials.
Your friend,
Ron
Posted by SLS on January 5, 2004, at 16:47:39
In reply to Re: SLS, read link (if you havn't already) » SLS, posted by Ron Hill on January 5, 2004, at 13:57:21
> > http://www.sciencedaily.com/releases/2004/01/040101091614.htm
>
> Scott,
>
> I want you to try this.
Yes sir! <big smile>
- Scott
Posted by Ron Hill on January 5, 2004, at 19:19:40
In reply to Re: SLS, read link (if you havn't already), posted by SLS on January 5, 2004, at 16:47:39
http://www.dr-bob.org/babble/social/20031229/msgs/296890.html
Posted by Larry Hoover on January 5, 2004, at 21:00:58
In reply to MRIs as treatment for bipolar disorder?, posted by nicky847 on January 5, 2004, at 9:52:56
Just published:
Am J Psychiatry. 2004 Jan;161(1):93-8.
Low-Field Magnetic Stimulation in Bipolar Depression Using an MRI-Based Stimulator.
Rohan M, Parow A, Stoll AL, Demopulos C, Friedman S, Dager S, Hennen J, Cohen BM, Renshaw PF.
OBJECTIVE: Anecdotal reports have suggested mood improvement in patients with bipolar disorder immediately after they underwent an echo-planar magnetic resonance spectroscopic imaging (EP-MRSI) procedure that can be performed within clinical MR system limits. This study evaluated possible mood improvement associated with this procedure. METHOD: The mood states of subjects in an ongoing EP-MRSI study of bipolar disorder were assessed by using the Brief Affect Scale, a structured mood rating scale, immediately before and after an EP-MRSI session. Sham EP-MRSI was administered to a comparison group of subjects with bipolar disorder, and actual EP-MRSI was administered to a comparison group of healthy subjects. The characteristics of the electric fields generated by the EP-MRSI scan were analyzed. RESULTS: Mood improvement was reported by 23 of 30 bipolar disorder subjects who received the actual EP-MRSI examination, by three of 10 bipolar disorder subjects who received sham EP-MRSI, and by four of 14 healthy comparison subjects who received actual EP-MRSI. Significant differences in mood improvement were found between the bipolar disorder subjects who received actual EP-MRSI and those who received sham EP-MRSI, and, among subjects who received actual EP-MRSI, between the healthy subjects and the bipolar disorder subjects and to a lesser extent between the unmedicated bipolar disorder subjects and the bipolar disorder subjects who were taking medication. The electric fields generated by the EP-MRSI scan were smaller (0.7 V/m) than fields used in repetitive transcranial magnetic stimulation (rTMS) treatment of depression (1-500 V/m) and also extended uniformly throughout the head, unlike the highly nonuniform fields used in rTMS. The EP-MRSI waveform, a 1-kHz train of monophasic trapezoidal gradient pulses, differed from that used in rTMS. CONCLUSIONS: These preliminary data suggest that the EP-MRSI scan induces electric fields that are associated with reported mood improvement in subjects with bipolar disorder. The findings are similar to those for rTMS depression treatments, although the waveform used in EP-MRSI differs from that used in rTMS. Further investigation of the mechanism of EP-MRSI is warranted.
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