![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by KXo on March 14, 2004, at 22:38:54
For Klonopin to mantain constant blood levels, how the doses have to be spaced?
I read in the benzo.org that Valium can be taken once every 12 hours or in some cases once every 24 hours. Xanax must be taken every 4-6 hours to maintain constant blood levels. What about Clonazepam?
Thank you!
KXo
Posted by DepNYer on March 15, 2004, at 16:05:23
In reply to Klonopin half-life, posted by KXo on March 14, 2004, at 22:38:54
The half life of klonopin can vary between 10 to 24 hours. The usual dosing is twice a day, but many get by with only once a day. Given it's slow onset of action, daily dosing is indicated for treating GAD or panic, rather than as a prn med for acute attacks.
Posted by KXo on March 17, 2004, at 15:12:02
In reply to Re: Klonopin half-life, posted by DepNYer on March 15, 2004, at 16:05:23
Thank you for answering DepNYer!
Could you help me some more?
How does the half life varies? Is it from a person to the other, or it can vary in the same person depending on the day?==KXo
> The half life of klonopin can vary between 10 to 24 hours. The usual dosing is twice a day, but many get by with only once a day. Given it's slow onset of action, daily dosing is indicated for treating GAD or panic, rather than as a prn med for acute attacks.
Posted by DepNYer on March 17, 2004, at 16:27:13
In reply to Re: Klonopin half-life, posted by KXo on March 17, 2004, at 15:12:02
It can vary from individual rates of metabolism as well as methods used to calculate half lives (according to the package insert from Roche, it's 30 to 60 hours, although studies independent of Roche have shown greater variability, possibly because of methodology variation, or, as it is metabolized by the CYP3A pathway, P450 inducers can effect the plasma levels and excretion rates). The exact half life is less important than the recognition of it's fairly long half life. This allows for once or twice a day use.
Posted by cybercafe on March 18, 2004, at 18:05:07
In reply to Re: Klonopin half-life, posted by DepNYer on March 17, 2004, at 16:27:13
> It can vary from individual rates of metabolism as well as methods used to calculate half lives (according to the package insert from Roche, it's 30 to 60 hours, although studies independent of Roche have shown greater variability, possibly because of methodology variation, or, as it is metabolized by the CYP3A pathway, P450 inducers can effect the plasma levels and excretion rates). The exact half life is less important than the recognition of it's fairly long half life. This allows for once or twice a day use.
what!? my doc said it was something like 6 or 8 hour half life... in fact.... i painstakingly found this to be true... at least.. i found if i were socializing 24/7 i would need to take it three times a day
Posted by djmmm on March 18, 2004, at 19:44:50
In reply to Re: Klonopin half-life, posted by cybercafe on March 18, 2004, at 18:05:07
> > It can vary from individual rates of metabolism as well as methods used to calculate half lives (according to the package insert from Roche, it's 30 to 60 hours, although studies independent of Roche have shown greater variability, possibly because of methodology variation, or, as it is metabolized by the CYP3A pathway, P450 inducers can effect the plasma levels and excretion rates). The exact half life is less important than the recognition of it's fairly long half life. This allows for once or twice a day use.
>
> what!? my doc said it was something like 6 or 8 hour half life... in fact.... i painstakingly found this to be true... at least.. i found if i were socializing 24/7 i would need to take it three times a dayThe ACTUAL half life of Klonopin ranges from 18-50 hrs
xanax is 6-12
Valium (parent drug) is 20-100, 36-200 for the active metabolite desmethyldiazepam
ativan is 10-20
The wide variations in half-life are due to several factors including: duration of use, individual metabolism...also, benzodiazepines tend to accumulate in the fatty tissues of your body.
Posted by KXo on March 18, 2004, at 20:36:09
In reply to Re: Klonopin half-life, posted by djmmm on March 18, 2004, at 19:44:50
> > > It can vary from individual rates of metabolism as well as methods used to calculate half lives (according to the package insert from Roche, it's 30 to 60 hours, although studies independent of Roche have shown greater variability, possibly because of methodology variation, or, as it is metabolized by the CYP3A pathway, P450 inducers can effect the plasma levels and excretion rates). The exact half life is less important than the recognition of it's fairly long half life. This allows for once or twice a day use.
> >
> > what!? my doc said it was something like 6 or 8 hour half life... in fact.... i painstakingly found this to be true... at least.. i found if i were socializing 24/7 i would need to take it three times a day
>
> The ACTUAL half life of Klonopin ranges from 18-50 hrs
>
> xanax is 6-12
>
> Valium (parent drug) is 20-100, 36-200 for the active metabolite desmethyldiazepam
>
> ativan is 10-20
>
> The wide variations in half-life are due to several factors including: duration of use, individual metabolism...also, benzodiazepines tend to accumulate in the fatty tissues of your body.All this variations make me think it is better to take it as needed, as I am doing, not taking it more than 3 times a day.
The problem is that I don't feel stable doing this way.It seems like the levels of Klonopin in a persons body will be constantly changing. Sometimes it is the clonazepam from the pill, sometimes the clonazepam from the fat and if you take it everyday.. from both! What do you think?
This half-life... if it is 15 hours for a person at a giving day, does it mean it will be reliefing his anxiety for 15 hours??
==KXo
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.