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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by Mike Lynch on April 29, 2004, at 23:29:06
I seem to have long-term cognitive deficits from the ssri's I have been taking , even when im off of them on. Well it seems when I change the dose , like for example , i'll lower it 5 milligrams , it seems as though my mental facalties return for about 4 days or so and then the effect wears off. During that period I feel more close to "normal" then I ever have , regarding mental functioning. Anyone have an explanation as to why it occurs. (In case you're assuming the medicine is worsening my abilities , so decreasing it of course would lessen the troubles , that isn't true because when i go completely off it the effect still wears off , i have to have medecine in my system for it to happen )
Posted by Keith Talent on April 30, 2004, at 2:39:09
In reply to Change in dose results in period of normalcy, posted by Mike Lynch on April 29, 2004, at 23:29:06
There are case reports in the psychiatric literature of mania occurring after sudden discontinuation of antidepressants (almost always broad-acting tricyclics). What you experienced may just be a very mild version of that.
Posted by Questionmark on April 30, 2004, at 3:21:08
In reply to Change in dose results in period of normalcy, posted by Mike Lynch on April 29, 2004, at 23:29:06
> I seem to have long-term cognitive deficits from the ssri's I have been taking , even when im off of them on. Well it seems when I change the dose , like for example , i'll lower it 5 milligrams , it seems as though my mental facalties return for about 4 days or so and then the effect wears off. During that period I feel more close to "normal" then I ever have , regarding mental functioning. Anyone have an explanation as to why it occurs.
i believe this is due to a temporary rebound in dopamine transmission after sustained SSRI-induced, indirect dopamine inhibition.
Posted by SLS on April 30, 2004, at 7:16:03
In reply to Change in dose results in period of normalcy, posted by Mike Lynch on April 29, 2004, at 23:29:06
> Well it seems when I change the dose , like for example , i'll lower it 5 milligrams , it seems as though my mental facalties return for about 4 days or so and then the effect wears off.
Yup.
Been there with a few drugs.
Nardil, Parnate, Effexor, nortriptyline, clorgyline - probably more that I can't remember.
Which drugs produce this effect for you? There might be a few clues there that you might be able to take advantage of.
- Scott
Posted by Mike Lynch on April 30, 2004, at 15:42:45
In reply to Re: Change in dose results in period of normalcy, posted by SLS on April 30, 2004, at 7:16:03
At first it happened when I was weening myself off Paxil , i'd start feeling back to myself , thinking I have recovered from my cognitive impairments. Then in 3 or 4 day's i'd return to my prior abnormal self. I remember this happening several times , and decided to mark any changes I made during the days I was functioning normally , it all pointed to the change in dosage. It's like my brain is dependent on this , in order to function normally.
This is the end of the thread.
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