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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 25 of 25. This is the beginning of the thread.
Posted by 1980Monroe on July 18, 2004, at 18:55:06
Not that i want to try it or anything, but i just wanto to know what the weakest antidepressants out there so i can avoid them.
I know there's some......
I know It varies, but just statistcally does anyone have know?
Thanks
Posted by 1980Monroe on July 18, 2004, at 18:56:56
In reply to what is the most ineffective antidepressant, posted by 1980Monroe on July 18, 2004, at 18:55:06
I read in one article that is the same a placebo.
Posted by 1980Monroe on July 18, 2004, at 18:59:29
In reply to what is the most ineffective antidepressant, posted by 1980Monroe on July 18, 2004, at 18:55:06
My main subject is not about St. Johns Wort, i just used that as an example to my main post.
By the way........st. johns wort really does not work, im serious!
THank you.
Posted by linkadge on July 18, 2004, at 19:36:26
In reply to Dr. Bob, please dont redirect the post above, posted by 1980Monroe on July 18, 2004, at 18:59:29
you're not exaclty right about St. Johns' wort. It may not have worked for you but, in the latest and *largest* trial both SJW and sertraline were less effective than the placebo, but SJW was more effective than sertraline in this case.
The SJw debate is not so clear cut.
Personally I think that trimipramine would be ineffective as a sole antidepreessant.
Linakdge
Posted by 1980Monroe on July 18, 2004, at 19:41:45
In reply to Re: Dr. Bob, please dont redirect the post above, posted by linkadge on July 18, 2004, at 19:36:26
Sorry for misinfo.
I read it one an abstract article, ill pull it up if you want me too, but i just put its the same really fast, so sorry about that.
Ok well thanks for your info. Hope more people will post too
Posted by zeugma on July 18, 2004, at 20:46:19
In reply to what is the most ineffective antidepressant, posted by 1980Monroe on July 18, 2004, at 18:55:06
I sometimes wonder if my pharmacist sneaked Benadryl into my capsules, if I'd notice a difference.
For Zoloft to come out below SJW, and even further below placebo, means that it's sub-sub-placebo. I doubt even trimipramine could beat that :-)
Posted by SLS on July 18, 2004, at 20:47:33
In reply to Re: Dr. Bob, please dont redirect the post above, posted by linkadge on July 18, 2004, at 19:36:26
> Personally I think that trimipramine would be ineffective as a sole antidepreessant.
Why?
I haven't seen much written about it - good or bad. It is a weird one.
From what I can tell:moclobemide (Manerix, Aurorix)
reboxetine (Edronax)
trazodone (Desyrel)
maprotiline (Ludiomil)
amoxapine (Asendin)
fluvoxamine (Luvox)
atomoxetine (Straterra)I'm not too sure about maprotiline, though. I don't known anyone who has taken it.
Amoxapine is effective, it just carries a higher rate of EPS than any other antidepressant. It's a pet peeve of mine.
- Scott
Posted by Racer on July 18, 2004, at 21:21:08
In reply to Re: Dr. Bob, please dont redirect the post above, posted by SLS on July 18, 2004, at 20:47:33
Posted by gardenergirl on July 18, 2004, at 21:24:28
In reply to Re: Dr. Bob, please dont redirect the post above, posted by SLS on July 18, 2004, at 20:47:33
Posted by King Vultan on July 18, 2004, at 22:53:39
In reply to Re: Dr. Bob, please dont redirect the post above, posted by SLS on July 18, 2004, at 20:47:33
I would also like to cast a vote for trazodone, but the stuff does seem to be good for sleep, anyway.
Trimipramine looks like it should be a loser, as it has essentially no direct effect on amine reuptake, but somehow, it has demonstrated antidepressant effects. I don't believe I would try it for depression, but I have thought about it for sleep. If it had any actual antidepressant effects, I suppose I'd consider that a bonus, but I wouldn't be at all surprised if it did.
Todd
Posted by SLS on July 18, 2004, at 23:14:22
In reply to Extra pyramidal symptoms? (nm), posted by gardenergirl on July 18, 2004, at 21:24:28
http://www.hubin.org/publicfamilyinfo/treatment/side_effects/side_effects_6_en.html
Posted by TenMan on July 18, 2004, at 23:26:09
In reply to and St. John's Wort is one of them....., posted by 1980Monroe on July 18, 2004, at 18:56:56
It's important to remember that the company that sponsored the zoloft/st. johns wort trial is the same company that manufactures zoloft. It is in thier best interests that sjw fail. There are numerous studies showing sjw to be an effective anti-d.
Just something to keep in mind.
Posted by Dr. Bob on July 19, 2004, at 1:52:58
In reply to Dr. Bob, please dont redirect the post above, posted by 1980Monroe on July 18, 2004, at 18:59:29
> please dont redirect the post above
> My main subject is not about St. Johns Wort, i just used that as an example to my main post.Posts about the main subject are fine here, but I would in fact like follow-ups regarding St. Johns Wort to be redirected to Psycho-Babble Alternative. Here's a link:
http://www.dr-bob.org/babble/alter/20040718/msgs/367643.html
Thanks,
Bob
Posted by cpallen79 on July 19, 2004, at 17:03:31
In reply to Re: Dr. Bob, please dont redirect the post above, posted by SLS on July 18, 2004, at 20:47:33
Hey guys, there is no such thing as an overall "ineffective" antidepressant... So many different chemistries are in place that one person's panacea is another's pandora... for example... I have very limited effectiveness with celexa and Lexapro, but for some people they are an absolute godsend. I have had great experiences with Paxil, for some people Paxil stinks. Same with Luvox, sometimes it works, sometiems it doesn't- all you ahve to do is check the OCD/anxiety boards where people are raving about it for their obsessions and depression. Finally, despite what "research" says, some people worship SJW, I am not one of them but have never tried it personally, so who am I to say? I take trazodone for sleep. As a sole antidepressant FOR ME, probably wouldn't do much, but I've read about some people taking it soley for depression and having amazing results! Other's swear by Zoloft whereas it's made some feel crazy. Finally, with Straterra, people are actually using it as an antidepressant with great results because it blocks NE and DOP.
Bottom line is that different meds do different things... no such thing as an "ineffective antidepressant"> > Personally I think that trimipramine would be ineffective as a sole antidepreessant.
>
> Why?
>
> I haven't seen much written about it - good or bad. It is a weird one.
>
>
> From what I can tell:
>
> moclobemide (Manerix, Aurorix)
> reboxetine (Edronax)
> trazodone (Desyrel)
> maprotiline (Ludiomil)
> amoxapine (Asendin)
> fluvoxamine (Luvox)
> atomoxetine (Straterra)
>
> I'm not too sure about maprotiline, though. I don't known anyone who has taken it.
>
> Amoxapine is effective, it just carries a higher rate of EPS than any other antidepressant. It's a pet peeve of mine.
>
>
>
> - Scott
Posted by SLS on July 19, 2004, at 20:06:10
In reply to ineffective medications » SLS, posted by cpallen79 on July 19, 2004, at 17:03:31
> Hey guys, there is no such thing as an overall "ineffective" antidepressant...
Just having a bit of fun.
:-)
Still, I have yet to meet a happy moclobemide customer.
- Scott
Posted by cpallen79 on July 19, 2004, at 20:41:34
In reply to Re: ineffective medications, posted by SLS on July 19, 2004, at 20:06:10
LOL, We'll have to watch for one :)
cheers
Chris> > Hey guys, there is no such thing as an overall "ineffective" antidepressant...
>
> Just having a bit of fun.
>
> :-)
>
> Still, I have yet to meet a happy moclobemide customer.
>
>
> - Scott
Posted by 1980Monroe on July 19, 2004, at 21:17:40
In reply to Re: ineffective medications » SLS, posted by cpallen79 on July 19, 2004, at 20:41:34
If there is any statistics...... I know it varies, but overall
Or maybe there again is no such thing as a "intolerable" antidepressant.
Matt
Posted by SLS on July 19, 2004, at 21:29:36
In reply to Ok, what is the most intolerable antidepressant, posted by 1980Monroe on July 19, 2004, at 21:17:40
> If there is any statistics...... I know it varies, but overall
Ironic, but moclobemide.
Of the ones that really work, maybe Wellbutrin.
- Scott
Posted by SLS on July 19, 2004, at 21:55:42
In reply to Re: Ok, what is the most intolerable antidepressant, posted by SLS on July 19, 2004, at 21:29:36
I'm sorry. I misread the post. I thought it asked which was the most "tolerable" antidepressant.
Most people who take moclobemide remark how clean the drug is. Wellbutrin is pretty clean, I think.
***************************
As far as "intolerable"...Protriptyline and clomipramine are not much fun.
***************************
- Scott
Posted by 1980Monroe on July 20, 2004, at 9:19:54
In reply to Re: Dr. Bob, please dont redirect the post above, posted by linkadge on July 18, 2004, at 19:36:26
It's mentioned the most in an "ineffective" antidepressant throught most of these posts.
Posted by Larry Hoover on July 20, 2004, at 9:32:33
In reply to Re: Is Trimipramine ever used?, posted by 1980Monroe on July 20, 2004, at 9:19:54
> It's mentioned the most in an "ineffective" antidepressant throught most of these posts.
It may be a poor antidepressant (like e.g. trazodone), but it is an excellent hypnotic.
I'm using low-dose (25 mg) trimipramine as a sleep aid.
Recent work on insomnia has pointed to the H1 histamine receptor as the key to the induction of sleep. Remeron has relatively high H1 binding, but three tricyclics are better yet. In declining order, they are doxepin, trimipramine, amitryptiline. As far as I know, there is no drug with higher H1 binding affinity than doxepin, at least within the antidepressant category.
Lar
Posted by Sad Panda on July 20, 2004, at 9:38:39
In reply to Re: Is Trimipramine ever used?, posted by 1980Monroe on July 20, 2004, at 9:19:54
> It's mentioned the most in an "ineffective" antidepressant throught most of these posts.
>
>Trimipramine isn't a serotonin or norepinephrine reuptake inhibitor which is why it is such an average AD. It is, however, a fairly potent antihistamine & a strong 5-HT2A antagonist(strongest for TCA's) which gives it good anxiolytic & sedative properties. It has never had any real success because it has no advantages over other TCA's but has had one big disadvantage, it's price.
Cheers,
Panda.
Posted by Sad Panda on July 20, 2004, at 9:44:24
In reply to Ok, what is the most intolerable antidepressant, posted by 1980Monroe on July 19, 2004, at 21:17:40
> If there is any statistics...... I know it varies, but overall
>
> Or maybe there again is no such thing as a "intolerable" antidepressant.
>
>
>
> Matt
>
>
>Amitriptyline has the worst side effects for most people, OTOH, it has been the most effective AD for most people too. There's no such thing as a free lunch: AD's that don't have side effects don't actually do anything.
Cheers,
Panda.
Posted by zeugma on July 20, 2004, at 12:12:33
In reply to Oops - I misread as tolerable antidepressant, posted by SLS on July 19, 2004, at 21:55:42
>As far as "intolerable"...
>
> Protriptyline and clomipramine are not much fun.
>
>
> ***************************
>
>
> - ScottI'm not going to worry about protriptyline, but what do you think would have fewer side effects: Lexapro plus nortriptyline, or clomipramine by itself?
The problem is that as antidepressants become more 'tolerable,' they also become less effective, and I wonder where the point comes when a series of individually 'tolerable' but relatively ineffective AD's starts to become as intolerable in terms of SE as a dirty, but highly effective, drug.
>
>
>
Posted by RetiredYoung on July 21, 2004, at 6:43:01
In reply to Re: Is Trimipramine ever used?, posted by Sad Panda on July 20, 2004, at 9:38:39
My neurologist prescribed Trimimpramine/Surmontil as a daily preventative medication for chronic daily headaches. At 25mg/night it's had fair, at best, results for me.
This is the end of the thread.
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