![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 8 of 8. This is the beginning of the thread.
Posted by TheOutsider on January 24, 2005, at 12:35:05
I'm really interested in this med because I think it might help my anxiety, particularly my social anxiety.
I think Lunesta had quite a positive experience with it for SA.It seems strange to me that there isn't more interest in Pregabalin on this board, especially consider its just been released in the US.
Posted by anodyne on January 24, 2005, at 13:04:27
In reply to Any new Pregabalin - Lyrica Experiences?, posted by TheOutsider on January 24, 2005, at 12:35:05
Is Lyrica available in the US yet? I know it is approved but Pfizer may not have started to distribute it yet. Has anyone had a presciption filled in the US yet?
Posted by Ritch on January 24, 2005, at 13:38:26
In reply to Any new Pregabalin - Lyrica Experiences?, posted by TheOutsider on January 24, 2005, at 12:35:05
> I'm really interested in this med because I think it might help my anxiety, particularly my social anxiety.
> I think Lunesta had quite a positive experience with it for SA.
>
> It seems strange to me that there isn't more interest in Pregabalin on this board, especially consider its just been released in the US.I think there is interest in it, but since it is basically a "re-arranged" gabapentin molecule, perhaps a lot of people don't expect it to offer much true advantage over gabapentin. I want to try it to see if I get the same adverse effects that gabapentin causes. If not, then I would like to use it as a sleep med and perhaps reduce my clonazepam.
Posted by lunesta on January 24, 2005, at 13:38:57
In reply to Re: Any new Pregabalin - Lyrica Experiences?, posted by anodyne on January 24, 2005, at 13:04:27
It isnt "Launched" yet in the US. It was approved, but Pfizer has not started distributing it to pharmacies....
Yes I had a great response at high dosages 600mg+ lasted all day long, great for anxiety, sleep, energy. It will give you a funny pressure headache for awhile, but this goes away and its really not bad, cause lyrica helps the pain of anything..i dont know what the FDA is going to put it in as far as controlled substance. Probably same category as benzos, which is the lowest i think.
Posted by lunesta on January 24, 2005, at 13:42:55
In reply to Re: Any new Pregabalin - Lyrica Experiences? » TheOutsider, posted by Ritch on January 24, 2005, at 13:38:26
Lyrica is NOT a reformulated Neurontin. Its a totally different chemical structure and makeup.
It affects the same receptors, the delta 2 calcium ligands or whatever there called, but it is a different drug. It is like super neurontin, but doesnt feel like neurontin really. It just shares lots of the effects.
At high dosages it feels more like GHB or XTC. This is why it got a controlled substance label from the FDA..
lunesta
Posted by TheOutsider on January 24, 2005, at 14:01:38
In reply to Re: Any new Pregabalin - Lyrica Experiences?, posted by anodyne on January 24, 2005, at 13:04:27
Unfortunatly I have no idea whether its available in US pharmacies, as opposed to just being aproved.
I do however think that it may well be more than just 'super nuerotin'. Even a slight chemical difference could lead to very different effects.
Posted by zmg on January 24, 2005, at 20:35:14
In reply to Any new Pregabalin - Lyrica Experiences?, posted by TheOutsider on January 24, 2005, at 12:35:05
It looks to me like the problem with Lyrica is probably two fold 1) its been scheduled a controlled substance 2) it wasn't approved for seizures or anxiety disorders.
It seems like a doctor might be less inclined to prescribe this off label. Any doctors?
Sounds like a fairly big defeat for Pfizer:
"First, federal regulators designated Lyrica as a controlled substance. As a drug subject to the rules of the Drug Enforcement Administration, statutory requirements for prescribing controlled substances are likely to make it less attractive in the eyes of some patients and physicians. Neurontin is not classified as a controlled substance, putting generic gabapentin manufacturers in a better selling position versus Lyrica despite fewer indications. The therapeutic benefit of Lyrica as compared to Neurontin is not dramatic, and this classification will only make Lyrica a harder drug to advertise and prescribe, making doctors more inclined to prescribe generic gabapentin.
Second, the major selling point for the product (expanded labeling) has not developed in the desired fashion Pfizer had intended. The FDA has reviewed Lyrica for four different indications -- neuropathic pain associated with diabetic peripheral neuropathy and postherpetic neuralgia, as an add-on therapy in the treatment of partial epileptic seizures, and for the treatment of generalized anxiety disorder in adults. Lyrica was only cleared for neuropathic pain due to diabetes and postherpetic neuralgia. The FDA has rejected Lyrica as a treatment for epileptic convulsions and anxiety. If Pfizer had gotten all the indications it was seeking for Lyrica, the drug could have been positioned not only as a first-line therapy for neuropathic pain and epilepsy but also as a viable substitute for benzodiazepines in the lucrative anxiety market. Anxiety disorders are considered the most prevalent of psychiatric disorders. An estimated 19 million adult Americans suffer from anxiety disorders. Generalized anxiety disorder is one of the prevalent anxiety disorders and affects 4 percent of the U.S. population."
Posted by zmg on January 24, 2005, at 20:38:20
In reply to Re: Any new Pregabalin - Lyrica Experiences?, posted by zmg on January 24, 2005, at 20:35:14
Meant to source the quote in the above post:
http://www.inpharm.com/External/InpH/1,2580,1-0-0-0-inp_intelligence_art-0-304370,00.html
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.