Psycho-Babble Medication Thread 457118

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Whats the MINIMUM washout Zoloft to Nardil ??

Posted by linkadge on February 13, 2005, at 10:23:20

Whats the MINIMUM washout Zoloft to Nardil ??

 

Re: Whats the MINIMUM washout Zoloft to Nardil ?? » linkadge

Posted by Nixon on February 13, 2005, at 10:42:10

In reply to Whats the MINIMUM washout Zoloft to Nardil ??, posted by linkadge on February 13, 2005, at 10:23:20

Hi,

I checked a few sources and 2 said the minimum was 14 days. One recommended 28 with no explanation. This is tricky and please don't take my word for it.
Good Luck. JN

 

Re: Whats the MINIMUM washout Zoloft to Nardil ?? » linkadge

Posted by jujube on February 13, 2005, at 11:14:06

In reply to Whats the MINIMUM washout Zoloft to Nardil ??, posted by linkadge on February 13, 2005, at 10:23:20

I have always heard that two weeks is the minimum (I think longer if you are going from Prozac to a MAOI). I think you have mentioned in previous posts that you have experienced Serotonin Syndrome in the past, so, if I were you, I would be careful and not push the envelope and try to move too quickly (just my 2 cents).

All the best to you Linkadge. Be well.

> Whats the MINIMUM washout Zoloft to Nardil ??

 

Re: Whats the MINIMUM washout Zoloft to Nardil ??

Posted by SLS on February 13, 2005, at 12:20:17

In reply to Whats the MINIMUM washout Zoloft to Nardil ??, posted by linkadge on February 13, 2005, at 10:23:20

> Whats the MINIMUM washout Zoloft to Nardil ??


5 half-lives?


- Scott

 

Re: Whats the MINIMUM washout Zoloft to Nardil ??

Posted by linkadge on February 13, 2005, at 12:49:54

In reply to Re: Whats the MINIMUM washout Zoloft to Nardil ??, posted by SLS on February 13, 2005, at 12:20:17

5 half lives would take me to about 3 percent of the drug concentration. For zoloft this is about 5 days.

Hmm. I would suppose that slow initation of the drug might also reduce chances of interaction.

Linkadge

 

Re: Whats the MINIMUM washout Zoloft to Nardil ?? » linkadge

Posted by Ritch on February 13, 2005, at 16:55:13

In reply to Re: Whats the MINIMUM washout Zoloft to Nardil ??, posted by linkadge on February 13, 2005, at 12:49:54

> 5 half lives would take me to about 3 percent of the drug concentration. For zoloft this is about 5 days.
>
> Hmm. I would suppose that slow initation of the drug might also reduce chances of interaction.
>
>
>
> Linkadge


I think that desmethyl-sertraline (the metabolite) is quite active and has a half-life of a couple of days. That would put 5 half-lives out to about 10 days... I'd be very careful.

 

Re: Whats the MINIMUM washout Zoloft to Nardil ??

Posted by qwerty6400 on February 13, 2005, at 19:20:47

In reply to Re: Whats the MINIMUM washout Zoloft to Nardil ?? » linkadge, posted by Ritch on February 13, 2005, at 16:55:13

7 days, if you:

*start on very low doses of Parnate (a quarter pill, i.e. 2.5mg, taken twice a day) and taper up gradually over a week

*purchase a home blood pressure monitor and stop taking Parnate if it spikes too high

*have some nifedipine or captopril on hand to take if blood pressure rises to hypertensive crisis levels


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