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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by linkadge on February 13, 2005, at 10:23:20
Whats the MINIMUM washout Zoloft to Nardil ??
Posted by Nixon on February 13, 2005, at 10:42:10
In reply to Whats the MINIMUM washout Zoloft to Nardil ??, posted by linkadge on February 13, 2005, at 10:23:20
Hi,
I checked a few sources and 2 said the minimum was 14 days. One recommended 28 with no explanation. This is tricky and please don't take my word for it.
Good Luck. JN
Posted by jujube on February 13, 2005, at 11:14:06
In reply to Whats the MINIMUM washout Zoloft to Nardil ??, posted by linkadge on February 13, 2005, at 10:23:20
I have always heard that two weeks is the minimum (I think longer if you are going from Prozac to a MAOI). I think you have mentioned in previous posts that you have experienced Serotonin Syndrome in the past, so, if I were you, I would be careful and not push the envelope and try to move too quickly (just my 2 cents).
All the best to you Linkadge. Be well.
> Whats the MINIMUM washout Zoloft to Nardil ??
Posted by SLS on February 13, 2005, at 12:20:17
In reply to Whats the MINIMUM washout Zoloft to Nardil ??, posted by linkadge on February 13, 2005, at 10:23:20
> Whats the MINIMUM washout Zoloft to Nardil ??
5 half-lives?
- Scott
Posted by linkadge on February 13, 2005, at 12:49:54
In reply to Re: Whats the MINIMUM washout Zoloft to Nardil ??, posted by SLS on February 13, 2005, at 12:20:17
5 half lives would take me to about 3 percent of the drug concentration. For zoloft this is about 5 days.
Hmm. I would suppose that slow initation of the drug might also reduce chances of interaction.
Linkadge
Posted by Ritch on February 13, 2005, at 16:55:13
In reply to Re: Whats the MINIMUM washout Zoloft to Nardil ??, posted by linkadge on February 13, 2005, at 12:49:54
> 5 half lives would take me to about 3 percent of the drug concentration. For zoloft this is about 5 days.
>
> Hmm. I would suppose that slow initation of the drug might also reduce chances of interaction.
>
>
>
> Linkadge
I think that desmethyl-sertraline (the metabolite) is quite active and has a half-life of a couple of days. That would put 5 half-lives out to about 10 days... I'd be very careful.
Posted by qwerty6400 on February 13, 2005, at 19:20:47
In reply to Re: Whats the MINIMUM washout Zoloft to Nardil ?? » linkadge, posted by Ritch on February 13, 2005, at 16:55:13
7 days, if you:
*start on very low doses of Parnate (a quarter pill, i.e. 2.5mg, taken twice a day) and taper up gradually over a week
*purchase a home blood pressure monitor and stop taking Parnate if it spikes too high
*have some nifedipine or captopril on hand to take if blood pressure rises to hypertensive crisis levels
This is the end of the thread.
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