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Dr. Bob is Robert Hsiung, MD,
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Posted by cubbybear on February 22, 2005, at 10:02:53
I was wondering. .. if Parkinson's is suspected of being caused by a loss of the dopamine-producing cells in the brain, would a continuous healthy supply of dopamine from MAOI use help prevent it? Anyone have any insight/links, etc. for this question?
Posted by linkadge on February 22, 2005, at 10:15:07
In reply to MAOIs prevent Parkinson's Disease?, posted by cubbybear on February 22, 2005, at 10:02:53
It's not really the extra dopamine that prevents the cells from dying. Ie taking cocaine certainly doesn't prevent parkinsons.
I believe it is something intrinsic about the way MAO-B inhibitors work, that makes them somewhat neuroprotective.
It's kind of still a grey area, but people aren't sure if deprenyl's antiparkinson action is due to MAO-B inhibition, antioxidant properties, or both.
So MAO-B inhibitors do have some neuroprotective properties. If this extends to mixed MAOA MAOB inhibitors is still unclear.Parnate, could perhaps provide symptomatic relief, however.
Linkadge
Posted by cubbybear on February 23, 2005, at 22:23:00
In reply to Re: MAOIs prevent Parkinson's Disease?, posted by linkadge on February 22, 2005, at 10:15:07
Interesting--i wonder if Moclobemide, a non-selective MAOI that inhibits both MAO-A and MAO-B, would also be effective. Oh well, they probably have tried experimenting with this. . .
This is the end of the thread.
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