![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 9 of 9. This is the beginning of the thread.
Posted by krybrahaha78 on February 26, 2005, at 22:28:45
I thought this was interesting, it would be awesome to have Luvox CR, you wouldnt have to take it twice a day.
Fluvoxamine CR is a Safe and Effective Maintenance Therapy for Generalised Social Anxiety Disorder
A DGReview of :"Fluvoxamine CR in the long-term treatment of social anxiety disorder: the 12- to 24-week extension phase of a multicentre, randomized, placebo-controlled trial"
International Journal of Neuropsychopharmacology11/21/2003
By Deanna M Green, PhD
Fluvoxamine CR remains safe and effective extended therapy in patients with generalised social anxiety disorder (GSAD), according to a recent multicentre study.Selective serotonin reuptake inhibitors (SSRIs) are the preferred treatment for SAD. SSRIs are also recommended for maintenance therapy; though little data are available from long-term pharmacotherapy trials. This information is particularly important since SAD is a chronic disorder.
Dan J. Stein, with University of Stellenbosch, Cape Town, South Africa, and the University of Florida, Gainesville, FL, United States, and colleagues evaluated the safety and efficacy of the SSRI fluvoxamine CR in the long term treatment of SAD.
The double-blind study included 112 patients with GSAD who showed at least minimal improvement after 12 week fluvoxamine treatment. Patients were randomised to receive fluvoxamine (100-300 mg/day) or placebo for an additional 12 weeks. Efficacy and safety were observed throughout treatment.
Further, yet slight improvement was observed with extended fluvoxamine treatment but none of the efficacy parameters reached statistical significance.
Greater decreases were seen in Liebowitz Social Anxiety Disorder Scale (LSAS) scores in patients continuing fluvoxamine treatment as compared to those given placebo. Clinical Global Impressions of Severity of illness (CGI-S) and Sheehan Disability Scale (SDS) scores also tended to be lower in the fluvoxamine group than in the placebo group.
The overall incidence of treatment-emergent signs and symptoms (TESS) was higher in the fluvoxamine CR group (68%) than in the placebo group (53%). Symptoms were primarily mild to moderate in severity. Furthermore, asthenia, headache, nausea, dry mouth, insomnia, sweating, and abnormal ejaculation were reported in more patients taking fluvoxamine. Signs of sexual dysfunction were also reported more frequently in fluvoxamine-treated patients.
Dr. Stein concludes that "these data support the long-term efficacy, safety, and tolerability of fluvoxamine CR in the treatment of GSAD." Furthermore, he recommends "that pharmacotherapy of this disorder should be continued beyond the acute phase."
Int J Neuropsychopharmacol 2003;6:317-323. "Fluvoxamine CR in the long-term treatment of social anxiety disorder: the 12- to 24-week extension phase of a multicentre, randomized, placebo-controlled trial"
Posted by banga on February 26, 2005, at 22:48:17
In reply to anyone know about this? ----Luvox CR!, posted by krybrahaha78 on February 26, 2005, at 22:28:45
I had seen that too--it is rather odd that they did not market an XR formula, given its short half life. Still don't quite understand its lack of popularity, and now the brand name withdrawn from the market....
Posted by Phillipa on February 26, 2005, at 23:55:48
In reply to Re: anyone know about this? ----Luvox CR!, posted by banga on February 26, 2005, at 22:48:17
So, they're not going to come out with a Cr Version? Darn!Then it would be back on the market. Why didn't the drug company persue the AD effects of Luvox. It's a good drug, and I still plan on asking the new pdoc on Monday if she will consider using it with me. Fondly, Phillipa
Posted by krybrahaha78 on February 27, 2005, at 1:35:09
In reply to Re: anyone know about this? ----Luvox CR!, posted by Phillipa on February 26, 2005, at 23:55:48
> So, they're not going to come out with a Cr Version? Darn!Then it would be back on the market. Why didn't the drug company persue the AD effects of Luvox. It's a good drug, and I still plan on asking the new pdoc on Monday if she will consider using it with me. Fondly, Phillipa
no they ARE coming out with a CR version, i dont know when it will be out tho
Posted by banga on February 27, 2005, at 7:57:09
In reply to Re: anyone know about this? ----Luvox CR!, posted by krybrahaha78 on February 27, 2005, at 1:35:09
Really? That would be good...I assumed if they are taking it off the market they are abandoning the whole med. So then they have a new patent perhaps?
Posted by Phillipa on February 27, 2005, at 14:32:56
In reply to Re: anyone know about this? ----Luvox CR!, posted by krybrahaha78 on February 27, 2005, at 1:35:09
That's Great! I was tired when I read the article. Maybe the pdoc's will get a renewed interest in it. I'm going back to read the article properly. Fondly, Phillipa
Posted by Phillipa on February 27, 2005, at 14:37:16
In reply to anyone know about this? ----Luvox CR!, posted by krybrahaha78 on February 26, 2005, at 22:28:45
Okay, manybe I'm dumb, but why is the article published in 2003? Has there been no further follow-up? Fondly, Phillipa
Posted by Kris Hebert on March 1, 2005, at 0:27:33
In reply to Re: anyone know about this? ----Luvox CR!, posted by Phillipa on February 27, 2005, at 14:37:16
Solvay has no plans to continue to pursue a CR version of Luvox. I called them inquiring about the reason why and I was told that Eon Labs, who was manufacturing the controlled release tablet, "was unable to produce consistant batch-to-batch potency". Both Solvay and Eon mutually decided to withdraw the FDA application.
This is really too bad, because I've been on every SSRI and Luvox has been the best for me. The few side effects that is caused me (sedation etc.) I'm sure would have abated with a CR version.
Perhaps someday.
kris
Posted by krybrahaha78 on March 3, 2005, at 0:00:03
In reply to Re: anyone know about this? ----Luvox CR!, posted by Kris Hebert on March 1, 2005, at 0:27:33
> Solvay has no plans to continue to pursue a CR version of Luvox. I called them inquiring about the reason why and I was told that Eon Labs, who was manufacturing the controlled release tablet, "was unable to produce consistant batch-to-batch potency". Both Solvay and Eon mutually decided to withdraw the FDA application.
>
> This is really too bad, because I've been on every SSRI and Luvox has been the best for me. The few side effects that is caused me (sedation etc.) I'm sure would have abated with a CR version.
>
> Perhaps someday.
>
> krisThats too bad. It would had been awesome to have a CR version of this drug. I too have been on every SSRI and this has also been by far the best, makes me wonder how much different luvox is compared to the other ssri's.
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.