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Dr. Bob is Robert Hsiung, MD,
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Posted by Rocket Jackson on September 22, 2005, at 0:40:05
I've been taking Klonopin 1-2x/week prn for social anxiety for three years now with no need for dose escalation. I recently started Cymbalta (for anxiety as recommended by a psych NP... not sure if I understand the rationale but went with it anyway) and then added Ambien 10mg each night to treat the insomnia I was suffering from the Cymbalta. Now, since being on the Ambien for a few weeks, it seems I've needed increased doses of Klonopin to achieve the desired effect. With Ambien as a GABA-1 agonist and Klonopin a GABA agonist, I guess it would make sense that cross-tolerance might exist, but has it been described scientifically or anecdotally? Any similar experiences out there? Thanks!
Posted by UgottaHaveHOPE` on September 23, 2005, at 1:51:48
In reply to Ambien and Klonopin cross-tolerance?, posted by Rocket Jackson on September 22, 2005, at 0:40:05
i took klonopin and restoril (different sleep aid) at the same time, and had a bad reaction. but again every med affects everyone differently.
i guess if you reason, taking both together would just make you more drowsy.
This is the end of the thread.
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