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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by alohashirt on October 17, 2005, at 22:24:34
One of the Attenace stories suggested that 20000 adults are using provigil off-label for ADHD. Here is my question: Given that Provigil is a different kind of drug to amphetamines or methylphenidatem, would one expect that Provigil+methylphenidate or Provigil + dexedrine would have a greater effect than simply methylphenidate or amphetamine on their own? Or would it just be a more complicated way of increasing a stimulant dose? Given how these medications are speculated to work is it reasonable to expect a complementary effect or just an additive effect?
Posted by rjlockhart98 on October 17, 2005, at 22:33:05
In reply to Provigil for ADHD question, posted by alohashirt on October 17, 2005, at 22:24:34
I would think this is addidive effect to the stimulant. I have drank energy drinks with Dexedrine, it some what gives it a more boost, but it doest actually increase the drug itself, gives a side kick.
Posted by med_empowered on October 18, 2005, at 4:04:36
In reply to Re: Provigil for ADHD question, posted by rjlockhart98 on October 17, 2005, at 22:33:05
I think I saw a couple studies (nothing exciting--small samples, not well randomized...just "for the hell of it" psychiatric experiments, I guess) where Provigil was co-administered with amphetamine. The one I can remember used very low-dose dexedrine (20mgs) along with full-dose Provigil, after the subjects had been taking full-dose Provigil for about a week. The study focused on side-effects, and it was pretty good--neither arm (provigil, or provigil+amphetamine) differed all that much from placebo in terms of side effects. Given Provigil's profile--low effects on locomotion, little effect on sleep quanitity or quality, very *mild* weight-reducing properties, low propensity to cause cardiovascular issues-- my guess would be that you'll see a synergistic combination; both meds working better, and at lower doses.
Posted by Bill LL on October 18, 2005, at 13:30:01
In reply to Provigil for ADHD question, posted by alohashirt on October 17, 2005, at 22:24:34
I think that it would be different than simply raising the dose of Ritalin. I think adding Provigil would be helpful, but I don't know whether or not it would be more helpful than just raising the Ritalin or Dexedrine dose.
I personally take 400 mg Provigil for ADD and it works pretty good. It also helps combat the tiredness from Lexapro (I also take Lamictal).
I never tried Adderal. But I prefer Provigil to Ritalin (actually I took Concerta), mainly because a single dose lasts longer.
> One of the Attenace stories suggested that 20000 adults are using provigil off-label for ADHD. Here is my question: Given that Provigil is a different kind of drug to amphetamines or methylphenidatem, would one expect that Provigil+methylphenidate or Provigil + dexedrine would have a greater effect than simply methylphenidate or amphetamine on their own? Or would it just be a more complicated way of increasing a stimulant dose? Given how these medications are speculated to work is it reasonable to expect a complementary effect or just an additive effect?
Posted by Paulbwell on October 20, 2005, at 1:37:09
In reply to Provigil for ADHD question, posted by alohashirt on October 17, 2005, at 22:24:34
I know a gent in his 60s with Narco who has taken Desoxyn Gradumets for decades 4-5 15mg SR. when they went off the market. he had to take the inferior Ovation IR Desoxyns 4, 5mg 4x daily they were insufficient, so he added 600mgs Provigal and it keeps him awake better, so the 2 work on different systems, and may be of benefit.
Cheers
This is the end of the thread.
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