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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 8 of 8. This is the beginning of the thread.
Posted by idolamine on May 29, 2006, at 14:08:25
these same syptoms occured once I escalated my dose of adderall, in the past. Even after long-term cessation of adderall, I still get hyperkinesia. Could this be related to selegeline?
Posted by Phillipa on May 29, 2006, at 14:15:36
In reply to hint on last thread (SLS?), posted by idolamine on May 29, 2006, at 14:08:25
I hope SLS come on. Love Phillipa
Posted by SLS on May 29, 2006, at 15:09:21
In reply to hint on last thread (SLS?), posted by idolamine on May 29, 2006, at 14:08:25
> these same syptoms occured once I escalated my dose of adderall, in the past. Even after long-term cessation of adderall, I still get hyperkinesia. Could this be related to selegeline?
I really don't know.
Selegiline is metabolized into L-amphetamine and L-methamphetamine. Their biological activities at therapeutic dosages are considered to be weak, though. Nonetheless, you might be sensitive to amphetamines and/or their effects on catecholamines.
I have no idea what the course of these side effects are. I don't know whether or not they disappear with continued use.
Hopefully, someone here will have more insight into your reaction to theses drugs. It almost sounds as if your dopamine receptors are too sensitive.
Sorry I couldn't be of more help.
- Scott
Posted by idolamine on May 29, 2006, at 19:56:33
In reply to Re: hint on last thread (SLS?), posted by SLS on May 29, 2006, at 15:09:21
Thanks for the response scott. Aren't the levo isomers inactive anyway? I'm at a quandry- I wonder if I should start serzone again- but if I stay on the selegeline, in your personal opinion, could it down-regulate DA receptors after awile? Thanks
> > these same syptoms occured once I escalated my dose of adderall, in the past. Even after long-term cessation of adderall, I still get hyperkinesia. Could this be related to selegeline?
>
> I really don't know.
>
> Selegiline is metabolized into L-amphetamine and L-methamphetamine. Their biological activities at therapeutic dosages are considered to be weak, though. Nonetheless, you might be sensitive to amphetamines and/or their effects on catecholamines.
>
> I have no idea what the course of these side effects are. I don't know whether or not they disappear with continued use.
>
> Hopefully, someone here will have more insight into your reaction to theses drugs. It almost sounds as if your dopamine receptors are too sensitive.
>
> Sorry I couldn't be of more help.
>
>
> - Scott
>
>
Posted by SLS on May 30, 2006, at 8:22:29
In reply to Re: hint on last thread (SLS?) » SLS, posted by idolamine on May 29, 2006, at 19:56:33
> Thanks for the response scott. Aren't the levo isomers inactive anyway?
I think they have weak actions at the DA transporter, but I may be wrong. Anyway, the amount of metabolite resulting from the Emsam patch is much reduced compared to oral delivery. I was thinking that you might be allergic to amphetamine. That might be far-fetched. I don't know.
How would you describe your experience with hyperkinesia?
> I'm at a quandry- I wonder if I should start serzone again- but if I stay on the selegeline, in your personal opinion, could it down-regulate DA receptors after awile? Thanks
It is reasonable to think that it would. Selegiline increases the levels of extracellular dopamine. I don't think the mechanisms involved in producing this increase are well understood, but they might be separate from MAO inhibition. To expose the postsynaptic membrane with the increased concentration of dopamine could produce a downregulation of DA receptors. This should occur after two weeks.
- Scott>
>
> > > these same syptoms occured once I escalated my dose of adderall, in the past. Even after long-term cessation of adderall, I still get hyperkinesia. Could this be related to selegeline?
> >
> > I really don't know.
> >
> > Selegiline is metabolized into L-amphetamine and L-methamphetamine. Their biological activities at therapeutic dosages are considered to be weak, though. Nonetheless, you might be sensitive to amphetamines and/or their effects on catecholamines.
> >
> > I have no idea what the course of these side effects are. I don't know whether or not they disappear with continued use.
> >
> > Hopefully, someone here will have more insight into your reaction to theses drugs. It almost sounds as if your dopamine receptors are too sensitive.
> >
> > Sorry I couldn't be of more help.
> >
> >
> > - Scott
> >
> >
>
>
Posted by idolamine on May 30, 2006, at 10:51:26
In reply to Re: hint on last thread (SLS?), posted by SLS on May 30, 2006, at 8:22:29
Hey scott- thanks again!
I would descrive the hyperkinesia not in terms of jerks or hyperactivity, but the execution of planned motor movement. Almost a manic state, but not of mind, of motor movements, where you start to execture behaviour towards a goal, and then switch spontaneously a few seconds into it, and in your mind, you can't apply the brakes. I've reduced my lamictal dose and it seems a little better. Would you consider it reasonable that too much glutumate could produce this? thanks so much.
Posted by idolamine on May 30, 2006, at 10:54:00
In reply to Re: hint on last thread (SLS?), posted by SLS on May 30, 2006, at 8:22:29
Hey scott- thanks again!
I would descrive the hyperkinesia not in terms of jerks or hyperactivity, but the execution of planned motor movement. Almost a manic state, but not of mind, of motor movements, where you start to execture behaviour towards a goal, and then switch spontaneously a few seconds into it, and in your mind, you can't apply the brakes. I've reduced my lamictal dose and it seems a little better. Would you consider it reasonable that too much glutumate could produce this? thanks so much.
Posted by SLS on May 30, 2006, at 11:09:36
In reply to Re: hint on last thread (SLS?) » SLS, posted by idolamine on May 30, 2006, at 10:51:26
> Hey scott- thanks again!
>
> I would descrive the hyperkinesia not in terms of jerks or hyperactivity, but the execution of planned motor movement. Almost a manic state, but not of mind, of motor movements, where you start to execture behaviour towards a goal, and then switch spontaneously a few seconds into it, and in your mind, you can't apply the brakes. I've reduced my lamictal dose and it seems a little better. Would you consider it reasonable that too much glutumate could produce this? thanks so much.With hyperlocomotor states, one usually thinks of dopamine.
Lamictal is thought to reduce glutamate, not increase it. One would think that reducing the dosage of Lamictal should allow for an increase in glutamate. I have a hunch that Lamictal increases dopaminergic neurotransmission indirectly. It is not unusual for people to react to Lamictal with psychomotor activation, anxiety, and mania. If Lamictal makes you feel worse, perhaps Provigil would make you feel better. It increases glutamate. You might want to try some magnesium and see how you react to it. Magnesium can produce a calming effect, perhaps acting to block NMDA receptors. If, instead, you react to it in a manner similar to Lamictal, you might indeed have underactive NMDA receptors.
Have you ever tried taking a neuroleptic antipsychotic?
- Scott
This is the end of the thread.
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