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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by blueberry on November 21, 2006, at 8:52:04
They exhibited an inhibitory effect on MAO-B. The IC(50) values of the four potent flavonoids, quercitrin, isoquercitrin, rutin, and quercetin on monoamine oxidase were 19.06, 11.64, 3.89, and 10.89 microM and enzyme kinetics analysis revealed apparent inhibition constants (K(i)) of 21.01, 2.72, 1.83, and 7.95 microM, respectively...
I see this a lot in medication studies...IC(50), microM, Ki...can anyone explain how to understand this stuff? What do these letters and numbers mean?
For example, above, quercetin has the highest numbers. Does that mean it is the weakest or the strongest? And in what spectrum range do its numbers fall? I mean, those numbers are relative to what?
Confused.
Posted by linkadge on November 21, 2006, at 10:19:00
In reply to What Does This Technical Stuff Mean?, posted by blueberry on November 21, 2006, at 8:52:04
The lower the Ki value, the higher the binding of that particular substance to the tested receptor.
So, from this data, it appears that rutin would would provide the most inihibition of monoamine oxidase B.
Linkadge
Posted by linkadge on November 21, 2006, at 10:25:07
In reply to What Does This Technical Stuff Mean?, posted by blueberry on November 21, 2006, at 8:52:04
What is a good source of rutin by the way???
Linkadge
Posted by Phillipa on November 21, 2006, at 12:23:27
In reply to Re: What Does This Technical Stuff Mean?, posted by linkadge on November 21, 2006, at 10:25:07
For that matter what is rutin? Love Phillipa not technical at all. Good think I'm not a pharmacist.I wouldn't have passed anyway
Posted by linkadge on November 21, 2006, at 12:34:28
In reply to Re: What Does This Technical Stuff Mean? » linkadge, posted by Phillipa on November 21, 2006, at 12:23:27
Its a dietary flavanoid, in fruits and vegetables I think.
Linkadge
Posted by Declan on November 21, 2006, at 17:00:18
In reply to Re: What Does This Technical Stuff Mean?, posted by linkadge on November 21, 2006, at 10:19:00
Rutin has a real measurable stimulant effect.
I don't know if this is true of quercetin or not.
This is the end of the thread.
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