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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 9 of 9. This is the beginning of the thread.
Posted by Crazy Horse on February 6, 2007, at 15:23:59
My Pdoc says he as a few patients who have done very well on Parnate for over 10 years. I sure hope i can be on Parnate (doing well of course) for 10+ years.
Please let me know if you are, or if you know of anyone who is doing well on Parnate and for what length of time. Any additional comments on Parnate are also welcomed.
-Monte
Posted by willyee on February 6, 2007, at 20:31:33
In reply to PARNATE..long term treatment?, posted by Crazy Horse on February 6, 2007, at 15:23:59
> My Pdoc says he as a few patients who have done very well on Parnate for over 10 years. I sure hope i can be on Parnate (doing well of course) for 10+ years.
>
> Please let me know if you are, or if you know of anyone who is doing well on Parnate and for what length of time. Any additional comments on Parnate are also welcomed.
>
> -Monte
Simple comment,put parnate,and maoi aside,what med PERIOD are people usualy able to stay on for 10 years.Im sure there out there,but if one used this board as a factor,you would HAVE to come to the conclusion that all of these meds will offer short term relief,or loose effectivness over time.I hate to bite my tongue as im SURE there are people who have been on a med/meds for a very long time,but honestly in general every med available according to most postings here will offer most reliaf at start and at the least diminish significantly.Im on parnate 5 years now,and i did a year off,does it work like it did the first year? No way.....was the year off it better,well it was the only time in my life i had a car accident,i had a miserable time then,so NO WAY,being on it now years later and less effective is still a benifit to my daily life.Hope that makes sense.
Also everyone is different,try to start it with the utmost enthusiaism,and excitiment,self thought can be a factor as well,i know some meds,even drugs dont work when your so anxious on its effect it simply never seems to come on.
You choose it,now let it do its job,relax and try to live.
Best wishes.
P.S The only drug i have seen over and over that offered relief of up to 20 yrs was the OLD NARDIL,appearently for many people this was pure gold,and also why so many people are EXTREMLY OUTRAGED at the formulation changed,to them,whether people debate it or not,they BELIEVE there life was pulled away from them for what im sure was mere pennies in profit.
Posted by Chairman_MAO on February 7, 2007, at 7:28:17
In reply to Re: PARNATE..long term treatment?, posted by willyee on February 6, 2007, at 20:31:33
I currently take 120mg/day Nardil with 45mg/day d-amphetamine. This is about as good as it gets, I think. There has been only a slight decrease in effectiveness from when I started the drug in 2005, which was remedied by dropping buprenorphine and raising the dose from 90 to 120mg/day.
Posted by willyee on February 7, 2007, at 14:19:41
In reply to Re: PARNATE..long term treatment? » willyee, posted by Chairman_MAO on February 7, 2007, at 7:28:17
> I currently take 120mg/day Nardil with 45mg/day d-amphetamine. This is about as good as it gets, I think. There has been only a slight decrease in effectiveness from when I started the drug in 2005, which was remedied by dropping buprenorphine and raising the dose from 90 to 120mg/day.
Glad to see your still swinging,knew you were lol,dont see you as the type to give in,glad for the update,interesting combo btw,peace !
Posted by Chairman_MAO on February 7, 2007, at 14:56:04
In reply to Re: PARNATE..long term treatment?, posted by willyee on February 7, 2007, at 14:19:41
Yeah, glad to see you're around, too. For me, Parnate wasn't nearly effective enough for my anxiety. For quite a while it felt really good, though, but as you have noticed the tolerance to the psychostimulant effect inevitably fades. I went all the way up to 200mg/day, and while that was a lot better than 60 (120 mg/day was about the minimum effective long-term dose for me), it still was nothing like the first month or two on it at 60mg/day. My libido was so strong it was impractical. It was, however, the first antidepressant to give me a taste of what actual relief from depression was like, and I'm glad I tried it first because Nardil has more side effects to deal with.
The only long-term side effect I've gotten from Nardil is weight gain: I went from 180lbs--where I was most of my life--to 245lbs, and then lost I think 5-10 of it. I honestly don't care that much, though, as being slim isn't too much fun if you can't stand to leave your room. I do miss wearing leather pants, but enjoy being able to walk around without looking at the ground the whole time more.
If at all possible, I'd recommend that if you need to drop Parnate for any reason, you try Nardil with d-amphetamine (good luck finding a doctor who does this, though). I got really lucky and found this Columbian guy (I find a lot of the time foreign psychiatrists seem to be a lot more "with it") with 35 years of experience who works for the local state medical school (so they have charity care/take medicaid) and who only takes on "treatment-resistant" cases. He actually told me that he feels he has a moral obligation to treat people like me, because nobody else gives them what they need. I am scared of what will happen when he retires, and hope that he remains in good health for at least another 20 years. :)
I had to start at 5mg/day d-amphetamine and go up by like 5-10mg every month or two, which was frustrating, but I could respect the fact that he didn't want to lose his license, given that everyone says this combination is supposed to kill me. He actually got a letter from the state medical board asking him to justify what he was doing, which he says happens all the time because he often ends up using doses of things well beyond what is recommended. I was his first MAOI+stimulant patient in all 35 years, though, which is really saying something. I think there must be under 1000 people in the US on this combination, which is very unfortunate.
Posted by UgottaHaveHope on February 7, 2007, at 23:26:28
In reply to Re: PARNATE..long term treatment? » willyee, posted by Chairman_MAO on February 7, 2007, at 14:56:04
I am on Emsam now, and thinking about switching to Parnate or Nardil. My primary diagnosis is generalized anxiety disorder. I noticed you said that Parnate did not help you enough with anxiety. Did Nardil do a better job? If so please explain. Thanks, Michael
PS How long did it take for Nardil to kick in?
Posted by Ken Blades on February 18, 2007, at 15:15:28
In reply to PARNATE..long term treatment?, posted by Crazy Horse on February 6, 2007, at 15:23:59
Hi Monte~
I've been on Parnate for nine years, still
doing well. There was more of a psychostimulant
effect for the first two years or so which has
leveled off...at times I felt really revved
up but in a good way. It does more for the
social anxiety I have which was the main
reason I started taking it in the first place.
It doesn't do much for depression.All in all, I'm doing a lot better with it than
without it.
----------------------------------------------
> My Pdoc says he as a few patients who have done very well on Parnate for over 10 years. I sure hope i can be on Parnate (doing well of course) for 10+ years.
>
> Please let me know if you are, or if you know of anyone who is doing well on Parnate and for what length of time. Any additional comments on Parnate are also welcomed.
>
> -Monte
Posted by Ken Blades on February 18, 2007, at 15:23:47
In reply to Re: PARNATE..long term treatment? » willyee, posted by Chairman_MAO on February 7, 2007, at 14:56:04
I'm curious as to how you felt when you got
to 200mg./day of Parnate...physical sensations/
side effects and mental effects.I'm on 70mg./day; my psydoc is willing to up it
a little but not much and certainly not to
200 mg./day...wow!I have high blood pressure as it is, and
Parnate adds to that so my doc is worried
about that when considering any dose increases.I wish I had a Parnate manufacturing facility
in my home...I'd experiment! ;)
Posted by Chairman_MAO on February 21, 2007, at 14:24:37
In reply to Re:Q for Chairman, posted by UgottaHaveHope on February 7, 2007, at 23:26:28
Yes, it helps a lot, but I don't have a huge amount of generalized anxiety. Parnate helped a lot with phobic anxiety, but made "jitteryness" worse.
I don't know how long it took to kick in because I just started taking 60mg/day of it after stopping Parnate the day before. EmSam is NOT a good drug for people with anxiety. Could you try tranylcypromine + a benzo?
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