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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 8 of 8. This is the beginning of the thread.
Posted by starfox on February 24, 2007, at 13:07:09
Hi everyone,
I was just wandering what tricyclic AD had the longest half life with regards to sleep?. From what I understand Doxepin Is very good at making you fall asleep but is there another tricyclic that would be better for actually keeping you asleep or is Dox the best?
Starfox.
Posted by notfred on February 24, 2007, at 13:47:20
In reply to What is the longest lasting TCA for sleep?, posted by starfox on February 24, 2007, at 13:07:09
> Hi everyone,
>
> I was just wandering what tricyclic AD had the longest half life with regards to sleep?. From what I understand Doxepin Is very good at making you fall asleep but is there another tricyclic that would be better for actually keeping you asleep or is Dox the best?
>
> Starfox.Doxipin is the best.
Doxipin is the most sedating TCA, it may take a bit to kick it, maybe an hour, but once it does
it knocks you out and keeps you asleep very well.
Posted by Phillipa on February 24, 2007, at 14:38:41
In reply to Re: What is the longest lasting TCA for sleep?, posted by notfred on February 24, 2007, at 13:47:20
Took l0mg of Pamelar once and was meshed to the bed til 2pm. Couldn't even move. Didn't take again. Wow it knocked me out good That was a baby dose too. Love Phillipa
Posted by Phillipa on February 24, 2007, at 14:48:14
In reply to Re: What is the longest lasting TCA for sleep?, posted by notfred on February 24, 2007, at 13:47:20
Googled it wilipekia says massive weight gain is a side effect. Love Phillipa ps gonna google pamelar
Posted by Phillipa on February 24, 2007, at 14:53:10
In reply to Re: What is the longest lasting TCA for sleep?, posted by Phillipa on February 24, 2007, at 14:38:41
Well no wonder pamelar did that to me not for thyroid patients which I am. Love Phillipa ps the doxepin has the sleep profile
Posted by notfred on February 24, 2007, at 15:09:59
In reply to Re: What is the longest lasting TCA for sleep?, posted by Phillipa on February 24, 2007, at 14:48:14
> Googled it wilipekia says massive weight gain is a side effect. Love Phillipa ps gonna google pamelar
Yes, weight gain is a real issue at AD doses, for sleep it may or may not be an issue. Like I said, it is the most sedating so for some that makes it too sedating & something like pamelor would be less sedating.
Posted by med_empowered on February 25, 2007, at 1:41:14
In reply to Re: What is the longest lasting TCA for sleep?, posted by notfred on February 24, 2007, at 15:09:59
I dont know if its the most sedating, but surmontil (trimipramine) can apparently improve the quality of sleep for some people. I imagine all the usual TCA problems apply, maybe an EPS/TD risk, too.
Posted by psychobot5000 on February 25, 2007, at 11:31:49
In reply to What is the longest lasting TCA for sleep?, posted by starfox on February 24, 2007, at 13:07:09
> I was just wandering what tricyclic AD had the longest half life with regards to sleep?. From what I understand Doxepin Is very good at making you fall asleep but is there another tricyclic that would be better for actually keeping you asleepI think Doxepin might indeed be the best, but trimipramine/surmontil is very similar, and (I gather) may have a longer half-life in some people(though slightly less sedation from H1 blocking, presumably). So that might be better for a few. Also, Remeron has a similar H1 blocking effect to doxepin, and a longer half-life(something like 33 hrs) than either of them. The disadvantage, I find, was its residual sedation during the day.
Though Remeron is usually thought of as an 'atypical' AD, I believe it is actually a tetracyclic in structure, with some pharmacalogical similarities to TCAs.
This is the end of the thread.
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