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Dr. Bob is Robert Hsiung, MD,
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Posted by tecknohed on August 13, 2007, at 15:44:32
Anyone know if Marplan (isocarboxazid) is still available in the UK?
Comin off Nardil & wanna try it again.
Also, for anyone wanting to try Nardil, I'd strongly advise against it. In short, I've found myself chasing something I cant get back - for 4+ years.
Nardil is '2 FACED'. I hate it.sorry dont take no notice if you're on it & all the best.
As for my question, thanks in advance.
Posted by Quintal on August 14, 2007, at 5:33:45
In reply to Marplan availability, posted by tecknohed on August 13, 2007, at 15:44:32
Marplan is still available in the UK. Here is an excerpt from the current BNF:
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ISOCARBOXAZID Less suitable
Additional information interactions (Isocarboxazid); hepatic impairment; pregnancy.Indications:
Depressive illnessCautions:
diabetes mellitus, cardiovascular disease, epilepsy, blood disorders, concurrent electroconvulsive therapy; elderly (great caution); monitor blood pressure (risk of postural hypotension and hypertensive responses—discontinue if palpitations or frequent headaches); if possible avoid abrupt withdrawal; severe hypertensive reactions to certain drugs and foods; avoid in agitated patients; porphyria (section 9.8.2); pregnancy (Appendix 4) and breast-feeding; surgery (section 15.1); interactions: Appendix 1 (MAOIs)Driving:
Drowsiness may affect performance of skilled tasks (e.g. driving)Contra-indications:
Hepatic impairment or abnormal liver function tests (Appendix 2), cerebrovascular disease, phaeochromocytoma; not indicated in manic phaseSide-effects:
Commonly postural hypotension (especially in elderly) and dizziness; less common side-effects include drowsiness, insomnia, headache, weakness and fatigue, dry mouth, constipation and other gastro-intestinal disturbances, oedema, myoclonic movement, hyperreflexia, elevated liver enzymes; agitation and tremors, nervousness, euphoria, arrhythmias, blurred vision, nystagmus, difficulty in micturition, sweating, convulsions, rashes, purpura, leucopenia, sexual disturbances, and weight gain with inappropriate appetite may also occur; psychotic episodes with hypomanic behaviour, confusion, and hallucinations may be induced in susceptible persons; suicidal behaviour (see Suicidal Behaviour and Antidepressant Therapy); jaundice has been reported and, on rare occasions, fatal progressive hepatocellular necrosis; paraesthesia, peripheral neuritis, peripheral neuropathy may be due to pyridoxine deficiency; hyponatraemia (see Hyponatraemia and Antidepressant Therapy, section 4.3 )
Dose:
Initially 30 mg daily in single or divided doses until improvement occurs (increased after 4 weeks if necessary to max. 60 mg daily for 4–6 weeks under close supervision), then reduced to usual maintenance dose 10–20 mg daily (but up to 40 mg daily may be required); elderly 5–10 mg daily; child not recommended.
--------------------------------------------------Isocarboxazid (Non-proprietary) Prescription-only medicine Less suitable
Tablets, pink, scored, isocarboxazid 10 mg. Net price 50 = £27.79. Label: 3, 10, patient information leaflet
http://www.bnf.org/bnf/bnf/53/3344.htm
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Dr. Bob is Robert Hsiung, MD,
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