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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 8 of 8. This is the beginning of the thread.
Posted by Amigan on October 27, 2007, at 20:45:42
Hello.
Take sulpiride as an expample. It is poorly absorbed, clorazepate which has unstable absorption and many others.
Does anyone know if snorting or let them melt under the tongue will lead to better absorption into the bloodstream?
Which of the 2 methods gives the best result?
Posted by bleauberry on October 28, 2007, at 15:58:21
In reply to Poorly absorbed meds: Alternative method?, posted by Amigan on October 27, 2007, at 20:45:42
Snorting is probably not a good idea. No idea what kind of damage the drugs could do to your inner sinuses.
Dissolving under the tongue is an option. Might be nasty if the med tastes bad. I have done that with various meds, herbs, vitamins and minerals. They all seem to work faster and stronger that way versus swallowing whole. I chew it up, sit it under the tongue, swish it around, whatever, for a few minutes. Then swallow with water. A lot of it will be absorbed in the oral tissues of the tongue, cheeks, and gums.
Posted by amigan on October 29, 2007, at 0:41:18
In reply to Re: Poorly absorbed meds: Alternative method?, posted by bleauberry on October 28, 2007, at 15:58:21
Thanks for answering.
Despite the possible damage that a drug could cause to my sinuses, do you think that snorting achieves better absorption than disolving it under the tongue?
Posted by Larry Hoover on October 29, 2007, at 7:40:13
In reply to Poorly absorbed meds: Alternative method?, posted by Amigan on October 27, 2007, at 20:45:42
> Hello.
> Take sulpiride as an expample. It is poorly absorbed, clorazepate which has unstable absorption and many others.
> Does anyone know if snorting or let them melt under the tongue will lead to better absorption into the bloodstream?
> Which of the 2 methods gives the best result?I wouldn't recommend snorting anything.
If you can stand the taste, sublingual tissues do allow for direct transfer of some drugs into the circulation, but that is dependent on solubility. Highly soluble drugs tend to have higher uptake overall, so the main advantages of sublingual uptake are speed of entry into the circulation, and avoidance of first pass metabolism. I don't think either of these benefits addresses your question.
Dosing recommendations already take into account uptake/bioavailability. Are you trying to save money?
Lar
Posted by amigan on October 29, 2007, at 8:40:37
In reply to Re: Poorly absorbed meds: Alternative method? » Amigan, posted by Larry Hoover on October 29, 2007, at 7:40:13
> > Hello.
> > Take sulpiride as an expample. It is poorly absorbed, clorazepate which has unstable absorption and many others.
> > Does anyone know if snorting or let them melt under the tongue will lead to better absorption into the bloodstream?
> > Which of the 2 methods gives the best result?
>
> I wouldn't recommend snorting anything.
>
> If you can stand the taste, sublingual tissues do allow for direct transfer of some drugs into the circulation, but that is dependent on solubility. Highly soluble drugs tend to have higher uptake overall, so the main advantages of sublingual uptake are speed of entry into the circulation, and avoidance of first pass metabolism. I don't think either of these benefits addresses your question.Ok.
> Dosing recommendations already take into account uptake/bioavailability. Are you trying to save money?Not really. More like to increase the effectiveness of a standard dose. Anyway, i understand your point.
Posted by tecknohed on October 30, 2007, at 17:20:50
In reply to Poorly absorbed meds: Alternative method?, posted by Amigan on October 27, 2007, at 20:45:42
I found snorting Provigil to be much stonger than taking it orally, but it did sting a bit. Likely to cause permanant damage if long term.
Dont forget, most drugs are bound to other chemicals to help absorption from the stomache. Many are bound to hydrochloric acid http://en.wikipedia.org/wiki/Hydrochloride . Examples: paroxetine hydrochloride, amitriptyline hydrochloride, thioridazine hydrochloride. You wouldn't want this stuff up your nose - you'd be basically snorting stomache acid!
Taking pills like a suppository would be just as potent as snorting it (probably more so), but you'd still probably end up with irritation. OUCH!
I remember I used to take Es like this - this way they BLEW MY HEAD OFF!Of course if a suppository form of the meds you take do exist, then they would be what to aim for, if you dont mind the mess! lol
teck
Posted by meAgain on November 1, 2007, at 0:19:29
In reply to Re: Poorly absorbed meds: Alternative method? » Amigan, posted by tecknohed on October 30, 2007, at 17:20:50
are you saying you could take any kind of med like a suppository such as concerta ?
Posted by tecknohed on November 1, 2007, at 4:32:27
In reply to Re: Poorly absorbed meds: Alternative method?, posted by meAgain on November 1, 2007, at 0:19:29
> are you saying you could take any kind of med like a suppository such as concerta ?
I believe so, yes. But you'd want to watch that dose - it would be way more powerfull. And Concerta is methylphenidate HYDROCHLORIDE so it might sting a bit!
XL or 'sustained release' forms of drugs would probably be pointless, especially if you 'need to go' before the drug has dissolved. Sustained release forms can take a whole day to dissolve & are MADE TO BE SWALLOWED.
I'm NOT recommending anyone take there meds up thier *** by the way! Just answering the original question.
:)
teck
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