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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 15 of 15. This is the beginning of the thread.
Posted by Bob on May 8, 2008, at 18:34:17
Does anyone know how long Deplin stays in the blood? I can't find any info whatsoever on half-life.
It seems like them classifying it as a "medical food" has allowed them to eschew having to document things like pharmacology or side effects.
Posted by Phillipa on May 8, 2008, at 23:37:47
In reply to Deplin Blood Levels, posted by Bob on May 8, 2008, at 18:34:17
I picked up finally a brochure on Deplin at my pdocs today. It says foof and side effects sugar pill and that it takes two weeks to work. Will write more tomorrow bed. Love Phillipa
Posted by Ron Hill on May 11, 2008, at 1:24:37
In reply to Deplin Blood Levels, posted by Bob on May 8, 2008, at 18:34:17
> Does anyone know how long Deplin stays in the blood? I can't find any info whatsoever on half-life.
------------
Bob,The following paper does not directly address your question, however, the graphed data presented in Figure 1 and Figure 2 are worthly of your examination.
As a side note, please recall that [6S]-5-methyltetrahydrofolate is the IUPAC name for L-methylfolate, and Deplin is 100% L-methylfolate. In other words, [6S]-5-methyltetrahydrofolate is just another name for Deplin.
http://www.ajcn.org/cgi/content/full/84/1/156#F1
-- Ron
Posted by undopaminergic on May 11, 2008, at 13:04:34
In reply to Re: Deplin Blood Levels » Bob, posted by Ron Hill on May 11, 2008, at 1:24:37
>
> As a side note, please recall that [6S]-5-methyltetrahydrofolate is the IUPAC name for L-methylfolate, and Deplin is 100% L-methylfolate.
>The last part of your statement is not correct; according to the prescribing information, Deplin tablets contain 7.5 mg of L-methylfolate, as well as: Dibasic Calcium Phosphate Dihydrate, Silicified Microcrystalline Cellulose 90, Silicified Microcrystalline Cellulose HD 90, Opadry II Blue 85F90748 (Polyvinyl Alcohol, Titanium Dioxide, PEG 3350, Talc and FD&C Blue #2), Magnesium Stearate and Carnauba Wax.
Posted by Bob on May 11, 2008, at 13:11:41
In reply to Re: Deplin Blood Levels » Bob, posted by Ron Hill on May 11, 2008, at 1:24:37
> > Does anyone know how long Deplin stays in the blood? I can't find any info whatsoever on half-life.
> ------------
> Bob,
>
> The following paper does not directly address your question, however, the graphed data presented in Figure 1 and Figure 2 are worthly of your examination.
>
> As a side note, please recall that [6S]-5-methyltetrahydrofolate is the IUPAC name for L-methylfolate, and Deplin is 100% L-methylfolate. In other words, [6S]-5-methyltetrahydrofolate is just another name for Deplin.
>
> http://www.ajcn.org/cgi/content/full/84/1/156#F1
>
> -- Ron
>Not sure I completely understand the charts, but seems like it shows the concentrations steadily increasing over the weeks. Can I assume that it might take about the same amount of time for the med to be metabolized out?
Posted by Ron Hill on May 11, 2008, at 18:08:09
In reply to Re: Deplin Blood Levels » Ron Hill, posted by Bob on May 11, 2008, at 13:11:41
>> http://www.ajcn.org/cgi/content/full/84/1/156#F1
--------> Not sure I completely understand the charts, but seems like it shows the concentrations steadily increasing over the weeks.
That's my take on it. For a constant dosage of Deplin, the plasma and red blood cell folate concentrations continually increase over the 24 week time period presented. I find it interesting that Deplin takes so long to reach steady-state conditions. It's a moving target if a pt is trying to determine his/her optimal daily dosage. Over the 24 weeks presented, the longer the pt takes a constant daily dosage, the more "potent" the dosage becomes.
> Can I assume that it might take about the same amount of time for the med to be metabolized out?
No. Here are some links that provide the type of information you are looking for:
1) See page 6 of this pdf document: http://www.metafolin.com/pdfs/Scientific_Review_13.12.pdf
2) See Figure 4 on page 10, and Table 2 on page 11 in the following document. PteGlu is folic acid and 5-CH3-H4PteGlu is L-methylfolate: http://www.metafolin.com/pdfs/Submission%20Letter%20Merck%20(Attachment%20II).pdf
Note: Both of the above documents are on the Metafolin website. Merck owns the patent on the process used to make L-methylfolate and the trademarked name is Metafolin. The L-methylfolate in Deplin, CerefolinNAC, Metanx, and the OTC's are all Metafolin.
Here is the URL for the Metafolin site. Click through the links on the home page. Lots of good information above and beyond what I have sited above. Don't overlook the Product Registration links. http://www.metafolin.com/
3) Scroll down to the bottom of this page on the Deplin site: http://www.deplin.com/HealthcareProfessionals,Deplin
4) Notice that Reference 17 is cited as the origin of these data on the Deplin site. Here is a link to Reference 17. It's a clean site (Nature), so it's safe to download: http://www.nature.com/bjp/journal/v141/n5/pdf/0705446a.pdf
-- Ron
Posted by Ron Hill on May 11, 2008, at 19:22:56
In reply to Re: Deplin Blood Levels, posted by undopaminergic on May 11, 2008, at 13:04:34
> > As a side note, please recall that [6S]-5-methyltetrahydrofolate is the IUPAC name for L-methylfolate, and Deplin is 100% L-methylfolate.
> The last part of your statement is not correct; according to the prescribing information, Deplin tablets contain 7.5 mg of L-methylfolate, as well as: Dibasic Calcium Phosphate Dihydrate, Silicified Microcrystalline Cellulose 90, Silicified Microcrystalline Cellulose HD 90, Opadry II Blue 85F90748 (Polyvinyl Alcohol, Titanium Dioxide, PEG 3350, Talc and FD&C Blue #2), Magnesium Stearate and Carnauba Wax.
Yes, and the Metafolin (L-methylfolate) in Deplin can contain up to 17% water, about 8% Calcium, and some other stuff. Have you ever heard the story of the nat and the camel?
I'm surprised that you did not notice the real boo-boo in my post. The IUPAC name is actually (6S)-N-[4-[[(2-amino-1,4,5,6,7,8-hexahydro-5-methyl-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid, calcium salt.
On another topic, thanks for the heads-up you gave me a while ago regarding the risks associated with the coadministration of phenelzine and phenylethylamine. I spent 12 hours of research on the topic after you drew my attention to the issue. Thanks again for the heads-up.
-- Ron
Posted by undopaminergic on May 15, 2008, at 11:23:46
In reply to Re: Deplin Blood Levels » undopaminergic, posted by Ron Hill on May 11, 2008, at 19:22:56
>
> Yes, and the Metafolin (L-methylfolate) in Deplin can contain up to 17% water, about 8% Calcium, and some other stuff. Have you ever heard the story of the nat and the camel?
>
> I'm surprised that you did not notice the real boo-boo in my post. The IUPAC name is actually (6S)-N-[4-[[(2-amino-1,4,5,6,7,8-hexahydro-5-methyl-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid, calcium salt.
>I wasn't actively on the hunt for errors to point out; the "100%" just happened to catch my attention. And no, I don't think I've heard of the camel & nat.
> On another topic, thanks for the heads-up you gave me a while ago regarding the risks associated with the coadministration of phenelzine and phenylethylamine. I spent 12 hours of research on the topic after you drew my attention to the issue. Thanks again for the heads-up.
>I'm glad that you found it stimulating, although I would have expected the risks in question to be known to you, considering that you had already noticed the blood pressure elevating effects of phenylethylamine.
Posted by Ron Hill on May 15, 2008, at 12:04:28
In reply to Re: Deplin Blood Levels, posted by undopaminergic on May 15, 2008, at 11:23:46
> I'm glad that you found it stimulating, although I would have expected the risks in question to be known to you, considering that you had already noticed the blood pressure elevating effects of phenylethylamine.
---------------
undopaminergic,
Yeah, based on my original research prior to implementing the trial, I knew there were risks associated in combining PEA with 75 mg/day of Nardil. However, you helped me to better understand the reaction mechanisms behind the risks.
As it turns out, however, there are a bunch of reasons why PEA is better than DLPA in my particular situation. For example, PEA has a much higher efficacy than DLPA for bipolar pts.
I take small sips from a water bottle throughout the day. The water bottle contains 16 mg of PEA in solution with 250 ml of water. I have done this for the past month without incident.
Thanks again for your help!
-- Ron
Posted by SLS on May 15, 2008, at 15:32:02
In reply to Re: Deplin Blood Levels » undopaminergic, posted by Ron Hill on May 15, 2008, at 12:04:28
I've decided to go up to 15.00mg (2 pills) of Deplin per day. I hope to see something positive within the next 3 days.
- Scott
Posted by Phillipa on May 15, 2008, at 20:04:25
In reply to Re: Deplin Blood Levels, posted by SLS on May 15, 2008, at 15:32:02
Scott ready what caused you to double your dose and please post results. Love Phillipa
Posted by Ron Hill on May 15, 2008, at 20:28:31
In reply to Re: Deplin Blood Levels, posted by SLS on May 15, 2008, at 15:32:02
> I've decided to go up to 15.00mg (2 pills) of Deplin per day. I hope to see something positive within the next 3 days.
---------------
FWIW, when I increased to 15 mg/day, I felt more depressed.
As always, best wishes to you my friend.
-- Ron
Posted by Phillipa on May 15, 2008, at 20:59:18
In reply to Re: Deplin Blood Levels » SLS, posted by Ron Hill on May 15, 2008, at 20:28:31
Ron how are you? Long time no talk. Love Phillipa
Posted by Bob on May 16, 2008, at 12:05:50
In reply to Re: Deplin Blood Levels » SLS, posted by Ron Hill on May 15, 2008, at 20:28:31
I gave up on Deplin a little over a week ago. Too much of a mixed bag. It gave me energy and seemed to have some odd anxiolytic effect, but the final straw was increased joint paint and itchy rash spots that broke out in a couple of places on my body. It also seemed to be depressogenic after awhile.
Posted by Ron Hill on May 26, 2008, at 3:10:59
In reply to Re: Deplin Blood Levels » Ron Hill, posted by Phillipa on May 15, 2008, at 20:59:18
> Ron how are you? Long time no talk. Love Phillipa
np (Dr Bob will get after us if we socialize on med page).
-- Ron xoxoxo
This is the end of the thread.
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