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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 11 of 11. This is the beginning of the thread.
Posted by dbc on June 10, 2008, at 14:13:06
I've been given a chance to try this interesting NE reuptake drug which if not effective will probably lead into MPH. Someone have any major experiences they can share?
Posted by B2chica on June 10, 2008, at 15:12:51
In reply to Whats the word on strattera?, posted by dbc on June 10, 2008, at 14:13:06
i was on that in '04 for about 8 mo. it was a GREAT appetite suppressant, other than that it didn't do much for me. sorry not much help here.
but i think others on this site did like it. check the archives.
b2c.
Posted by SLS on June 11, 2008, at 5:03:25
In reply to Whats the word on strattera?, posted by dbc on June 10, 2008, at 14:13:06
> I've been given a chance to try this interesting NE reuptake drug which if not effective will probably lead into MPH. Someone have any major experiences they can share?
In my estimation, Strattera is a wonder drug for people with ADD ADHD who don't respond well to other treatments, especially in adults. I have never seen it work well for depression, even in combination with other drugs. You might as well give it a try. You never know how any one person will react to a given drug. However, if you do not respond to the maximum dosage after 4 weeks, I would begin planning your next move.
A truly effective selective NE reuptake inhibitor is desipramine.
Have you tried a tricyclic yet?
Please discuss with your doctor the desirability of taking periodic blood tests, as Strattera has been known to adversely alter liver function.
- Scott
Posted by linkadge on June 11, 2008, at 7:04:32
In reply to Re: Whats the word on strattera? » dbc, posted by SLS on June 11, 2008, at 5:03:25
Hi SLS,
I am taking straterra too and find it to be very helpful. You're right, I don't think its a robust AD, but it does have a positive impact on my mood.
Nevertheless, has anyone heard any updated info on the liver issues? Ie how extensive it is?
Is atomoxatine hepatotoxic in general or were these reactions idosyncratic?
I guess we'll know more in the future. Doctor didn't want to switch to desipramine as it supposedly has a high rate of cardiac mortality (higher than other TCA's)?
Linkadge
Posted by SLS on June 11, 2008, at 9:33:31
In reply to Re: Side question about liver issues, posted by linkadge on June 11, 2008, at 7:04:32
> Hi SLS,
>
> I am taking straterra too and find it to be very helpful. You're right, I don't think its a robust AD, but it does have a positive impact on my mood.I know an adult who was originally diagnosed and treated as having Major Depressive Disorder. After many treatment failures, his doctor reconsidered the diagnosis and treated him for ADD using Strattera. The improvement in his depressed mood was remarkable. Adult ADD can have symptoms similar to both bipolar and unipolar affective disorders.
- Scott
Posted by Phillipa on June 11, 2008, at 12:21:58
In reply to Re: Side question about liver issues, posted by SLS on June 11, 2008, at 9:33:31
Scott how can it act like both and what's this about straterra and liver so many people take it? Phillipa
Posted by 10derHeart on June 11, 2008, at 14:02:16
In reply to Whats the word on strattera?, posted by dbc on June 10, 2008, at 14:13:06
Here are the threads where I've posted about Strattera before - there are tons more in the archives back from 2003-2004, though:
http://www.dr-bob.org/babble/20080316/msgs/819715.html
http://www.dr-bob.org/babble/20060310/msgs/618979.htmlhttp://www.dr-bob.org/babble/20070719/msgs/771814.html
Still taking 80mgs and fine. Used to have LFT every six months, but changed docs, moved so I have neglected that. It may not be necessary, but after Lily put the black box warning on, one ex-pdoc felt "better safe than sorry," but left it to me how often to check.
I've been taking it for 4.5 years now.
If my incredibly long, annoying and probably hard to follow (hey the med helps, not a cure! ;-) posts don't answer your questions, just ask me here. I am somewhat of a cheerleader for Strattera, but I do seem to be in the minority, here and all over the 'net. It's been an excellent ADD med for me and may be providing AD relief as well - hard to tell as I went directly from a Prozac taper to Strattera...
best to you.... - 10der
Posted by iforgotmypassword on June 11, 2008, at 18:57:30
In reply to Re: Side question about liver issues » SLS, posted by Phillipa on June 11, 2008, at 12:21:58
i want to know if increased cortisol caused by certain drugs will or won't cause collagen breakdown. i know it seems like a narcisstic concern, but given how much of our lives some of us have lost...
Posted by linkadge on June 11, 2008, at 19:36:26
In reply to Re: Side question about liver issues, posted by iforgotmypassword on June 11, 2008, at 18:57:30
Hard to say. High cortisol can do bad things. Is there any evidence that atomoxatine increases cortisol after long term administration?
Linkadge
Posted by 10derHeart on June 11, 2008, at 20:06:21
In reply to Re: Side question about liver issues, posted by linkadge on June 11, 2008, at 19:36:26
Are there any studies, etc., out there regarding *anything* about long time Strattera use? I've looked, as I'll be closing in on 5 years,and would love to read anything that's been learned about it.
Shoot, when I Googled I didn't even run across any message boards, blogs, etc. with messages more recent than 2004/05....strange...
Posted by undopaminergic on June 20, 2008, at 16:58:21
In reply to Re: Whats the word on strattera? » dbc, posted by 10derHeart on June 11, 2008, at 14:02:16
I'd be interested in your comparative experiences with other noradrenergic agents. In particular:
1. reboxetine, which should be very close to atomoxetine in its pharmacological profile
2. tricyclic noradrenaline reuptake inhibitors
3. methylphenidate, which is an inhibitor of both dopamine and noradrenaline reuptake.
4. guanfacine, a direct agonist of the adrenergic receptor believed to be most relevant to ADHD - namely alpha2.
This is the end of the thread.
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