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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 4 of 4. This is the beginning of the thread.
Posted by mike1975 on September 24, 2008, at 21:26:31
Hi everyone,I can't figure out what they are talking about. What is ERP N1? Does anybody know?
ERP N1 as a Treatment Predictor of GAD
This study is currently recruiting participants.
Verified by Inje University, November 2007Sponsored by: Inje University
Information provided by: Inje University
ClinicalTrials.gov Identifier: NCT00613067Purpose
Amplitude changes of the N1 and the N1/P2 ERP component in response to different tone intensities have been suggested as a correlative of central serotonergic activity. A strong loudness dependence amplitude increase (strong intensity dependence) reflects low serotonergic neurotransmission and vice versa. Many researchers assumed that the brain serotonergic activity could influence treatment response of highly selective serotonin reuptake inhibitors in depression and anxiety disorders. There are a couple of studies reporting associations of N1 amplitude intensity dependence with response to Citalopram (positive correlation) and Reboxetine (negative correlation) treatment in major depressive disorder patients. But so far there have been no reports about associations between ERP N1 and antidepressant response in GAD patients.So, it would be very interesting to explore the correlations between ERP N1 amplitude change and the Escitalopram treatment responsiveness in GAD patients.
Mike
Posted by Phillipa on September 24, 2008, at 23:51:28
In reply to weird clinical trial, posted by mike1975 on September 24, 2008, at 21:26:31
Have no idea what so ever???? Phillipa
Posted by 10derHeart on September 25, 2008, at 2:49:53
In reply to Re: weird clinical trial » mike1975, posted by Phillipa on September 24, 2008, at 23:51:28
probably.....
Event-Related Potential
I've seen the acronym before, a couple years ago, in something I was trying to read/understand that a neurologist had written. (why I recall this, I have no clue.....nerd/dork/geek stuff, I guess ;-)
Don't ask me to explain it, though....but probably you can Google the phrase....
Posted by seldomseen on September 25, 2008, at 6:52:17
In reply to weird clinical trial, posted by mike1975 on September 24, 2008, at 21:26:31
I guess they are saying that changes in size of the N1 wave predict response to certain SSRIs.
http://www.audiospeech.ubc.ca/haplab/aep.htm
To see the N1 wave in the figure, go to print preview and magnify the page to at least 150%
Seldom.
This is the end of the thread.
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