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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 12 of 12. This is the beginning of the thread.
Posted by myco on May 3, 2009, at 11:43:49
I decided to raise my Nardil dose to 90mg this morning...the energy/concentration/motivation part of the med had died at 75mg (I was on 75 for months). I'm assuming this is a DA issue.
I was originally going to add Memantine before raising to see if I could get that part of Nardil back but raised instead...now I have this Memantine and not sure what to do with it.
So...question. Should Memantine be added to Nardil while it is still effective (ie sometime in near few weeks as 90mg stabilizes) or wait until 90mg "poops out" then add?
Augment to maintain effectiveness or bring back effectiveness?
Posted by Phillipa on May 3, 2009, at 12:40:15
In reply to Augment Nardil w/ Memantine b4 or after 'poopout'?, posted by myco on May 3, 2009, at 11:43:49
Glad to see you. Love Phillipa
Posted by Zana on May 3, 2009, at 15:15:43
In reply to Augment Nardil w/ Memantine b4 or after 'poopout'?, posted by myco on May 3, 2009, at 11:43:49
DK about your medication question but it is nice to see you back. How have you been?
Zana
Posted by SLS on May 3, 2009, at 16:15:17
In reply to Augment Nardil w/ Memantine b4 or after 'poopout'?, posted by myco on May 3, 2009, at 11:43:49
> So...question. Should Memantine be added to Nardil while it is still effective (ie sometime in near few weeks as 90mg stabilizes) or wait until 90mg "poops out" then add?
No data.
Just guesses.
I would add it now. You cover both scenarios with having the drug on board now. It is harder to recapture an antidepressant response once it is lost than it is to maintain it.
A friend of mine told me that she didn't feel the positive effects of memantine until she was on it for at least a month.
- Scott
Posted by myco on May 3, 2009, at 16:31:37
In reply to Re: Augment Nardil w/ Memantine b4 or after 'poopout'?, posted by Zana on May 3, 2009, at 15:15:43
> DK about your medication question but it is nice to see you back. How have you been?
>
> ZanaHi Zana.
I've been fighting off the urge to put a knife in my chest the last few days but doing better today.
Posted by myco on May 3, 2009, at 16:32:21
In reply to Re: Augment Nardil w/ Memantine b4 or after 'poopout'? » myco, posted by SLS on May 3, 2009, at 16:15:17
Thanks for the response SLS. Every guess and bit of opinion helps
> > So...question. Should Memantine be added to Nardil while it is still effective (ie sometime in near few weeks as 90mg stabilizes) or wait until 90mg "poops out" then add?
>
> No data.
>
> Just guesses.
>
> I would add it now. You cover both scenarios with having the drug on board now. It is harder to recapture an antidepressant response once it is lost than it is to maintain it.
>
> A friend of mine told me that she didn't feel the positive effects of memantine until she was on it for at least a month.
>
>
> - Scott
Posted by desolationrower on May 3, 2009, at 23:20:40
In reply to Re: Augment Nardil w/ Memantine b4 or after 'poopout'? » myco, posted by SLS on May 3, 2009, at 16:15:17
> > So...question. Should Memantine be added to Nardil while it is still effective (ie sometime in near few weeks as 90mg stabilizes) or wait until 90mg "poops out" then add?
>
> No data.
>
> Just guesses.
>
> I would add it now. You cover both scenarios with having the drug on board now. It is harder to recapture an antidepressant response once it is lost than it is to maintain it.
>
> A friend of mine told me that she didn't feel the positive effects of memantine until she was on it for at least a month.
>
>
> - Scottisn't this just an artifact of the fact that maintaining non-depressed state is easier than causing remission?
-d/r
PS hi myco good to see you are you ok from pnomoneua?
Posted by myco on May 3, 2009, at 23:37:07
In reply to Re: Augment Nardil w/ Memantine b4 or after 'poopout'?, posted by desolationrower on May 3, 2009, at 23:20:40
hey d/r
ya im ok...that antibiotic really took a piece out of my head though...sent me pseudo-bipolar.
Do you have any experience w/ Ondansetron?m
> > > So...question. Should Memantine be added to Nardil while it is still effective (ie sometime in near few weeks as 90mg stabilizes) or wait until 90mg "poops out" then add?
> >
> > No data.
> >
> > Just guesses.
> >
> > I would add it now. You cover both scenarios with having the drug on board now. It is harder to recapture an antidepressant response once it is lost than it is to maintain it.
> >
> > A friend of mine told me that she didn't feel the positive effects of memantine until she was on it for at least a month.
> >
> >
> > - Scott
>
> isn't this just an artifact of the fact that maintaining non-depressed state is easier than causing remission?
>
> -d/r
>
> PS hi myco good to see you are you ok from pnomoneua?
Posted by SLS on May 4, 2009, at 6:12:13
In reply to Re: Augment Nardil w/ Memantine b4 or after 'poopout'?, posted by desolationrower on May 3, 2009, at 23:20:40
> > > So...question. Should Memantine be added to Nardil while it is still effective (ie sometime in near few weeks as 90mg stabilizes) or wait until 90mg "poops out" then add?
> >
> > No data.
> >
> > Just guesses.
> >
> > I would add it now. You cover both scenarios with having the drug on board now. It is harder to recapture an antidepressant response once it is lost than it is to maintain it.
> >
> > A friend of mine told me that she didn't feel the positive effects of memantine until she was on it for at least a month.
> >
> >
> > - Scott
>
> isn't this just an artifact of the fact that maintaining non-depressed state is easier than causing remission?
>
> -d/r
>
> PS hi myco good to see you are you ok from pnomoneua?Not really. I witnessed one woman who was brought out of a severe depression that had lasted several years by her taking lithium. She remained absolutely healthy for over eight years. Then she changed doctors. The new doctor decided that his first intervention would be to have her discontinue the lithium. She relapsed into depression three weeks later, whereupon lithium was restarted at the same dosage. Nothing. The therapeutic response was not recaptured. She is going on 20 years of unrelenting double depression despite being a research patient at the NIMH for over 1 1/2 years and trying just about everything out there.
My own story reflects hers. I once responded with a 100% improvement - total remission - using a combination of Parnate and desipramine. It never pooped out. However, my doctor at the time had me discontinue it. When I relapsed two months later, he gave me Parnate only. For months I languished while I let him play with dosages. Then, when desipramine was again combined with Parnate - nothing. I could not recapture the therapeutic response.
- Scott
Posted by uncouth on May 4, 2009, at 21:56:19
In reply to Re: Augment Nardil w/ Memantine b4 or after 'poopout'? » desolationrower, posted by SLS on May 4, 2009, at 6:12:13
...and I was doing in retrospect pretty A-OK on a combination of 225 Effexor + 200mg Lamictal 4 years ago. I decided to slowly taper off both, figuring "oh heck i'm feeling ok, i don't need these anymore".
relapsed a few months later.
now going on 4 years of trials...across the board, through all classes of meds, dosages, and combos, and rTMS, and ECT....so far, nothing has taken me back to where I was when I was stabilized on 225 Effx + 200 Lamict.
So there's another datapoint for you.
Posted by Phillipa on May 5, 2009, at 19:11:26
In reply to Re: Augment Nardil w/ Memantine b4 or after 'poopo, posted by uncouth on May 4, 2009, at 21:56:19
Uncouth have you thought of retrying the effexor and lamictal? Phillipa
Posted by desolationrower on May 13, 2009, at 3:08:43
In reply to Re: Augment Nardil w/ Memantine b4 or after 'poopout'? » desolationrower, posted by SLS on May 4, 2009, at 6:12:13
> >
> > isn't this just an artifact of the fact that maintaining non-depressed state is easier than causing remission?
> >
> > -d/r
> >
> > PS hi myco good to see you are you ok from pnomoneua?
>
> Not really. I witnessed one woman who was brought out of a severe depression that had lasted several years by her taking lithium. She remained absolutely healthy for over eight years. Then she changed doctors. The new doctor decided that his first intervention would be to have her discontinue the lithium. She relapsed into depression three weeks later, whereupon lithium was restarted at the same dosage. Nothing. The therapeutic response was not recaptured. She is going on 20 years of unrelenting double depression despite being a research patient at the NIMH for over 1 1/2 years and trying just about everything out there.
>
> My own story reflects hers. I once responded with a 100% improvement - total remission - using a combination of Parnate and desipramine. It never pooped out. However, my doctor at the time had me discontinue it. When I relapsed two months later, he gave me Parnate only. For months I languished while I let him play with dosages. Then, when desipramine was again combined with Parnate - nothing. I could not recapture the therapeutic response.
>
>
> - Scotti don't know if that still isn't the same thing. i don't think taht ADs ever do more than say 20% of the anti-depressing, but sometimes the stars line up right so that that 20% is enough for someone. at least, thats my interpretation of the placebo effect data.
-d/r
This is the end of the thread.
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