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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 4 of 4. This is the beginning of the thread.
Posted by PetersKeys on June 9, 2009, at 20:06:56
Can a Methadone patient take Parnate safely? My pschyciatrist says its ok as long as I stay strictt with the diet but my general MD says its a risky mix. So I wanted to look for a 3rd opinion right here. Im almost at my wits end with depression and my pschy thinks Im treatment resistant, hence the MAOI. Im just scared since Im a methadone patient and don't wanna get a crisis or seratonin syndrome.
Posted by desolationrower on June 10, 2009, at 17:03:56
In reply to Can Methadone Patient take Parnate?, posted by PetersKeys on June 9, 2009, at 20:06:56
Methadone inhibits serotonin and norephinephrine uptake into rat brain synaptosomes and synaptic vesicles in vitro but not in vivo.
Slotkin TA, Seidler FJ, Whitmore WL.Methadone in vitro inhibited biogenic amine uptake into synaptosomes isolated from rat whole brain; the IC50 for inhibition of serotonin uptake was between 0.1 and 1 micron, and for norepinephrine uptake, 10 micron when the serotonin or norepinephrine concentration was 0.05 micron. Methadone in vitro also inhibited uptake of norepinephrine into rat brain synaptic vesicles to the same extent that it inhibited synaptosomal norepinephrine uptake. In all cases, all cases, morphine in vitro was much less effective in blocking uptake. However, in vivo acute or chronic administration of methadone to rats failed to cause inhibition of serotonin or norepinephrine uptakes in synaptosomes isolated from the brains of treated rats, nor was inhibition of vesicular norepinephrine uptake produced. Amine uptake in situ also was unaffected by methadone administration, as evidenced by normal incorporation of intracisternally administered 3H-serotonin into synaptic endings. These data show that inhibition of synaptosomal and vesicular biogenic amine uptake by methadone in vitro is probably not a major determinant of the alterations in biogenic amine turnover caused by methadone administration. Thus, results obtained with platelets and adrenomedullary chromaffin vesicles, in which methadone administration does cause effective inhibition of amine uptake in vivo, cannot be extended to the central nervous system.
i'd say it seems safe, but i'd keep an antidote around
and just being depressed is a risky thing
-d/r
Posted by Sigismund on June 10, 2009, at 19:41:00
In reply to Can Methadone Patient take Parnate?, posted by PetersKeys on June 9, 2009, at 20:06:56
I don't really know....I thought it was iffy.
You could try titrating up on the Parnate really slowly.
Posted by PetersKeys on June 10, 2009, at 21:11:08
In reply to Re: Can Methadone Patient take Parnate?, posted by Sigismund on June 10, 2009, at 19:41:00
yea thats what Im going to do probably. around 20mg.
This is the end of the thread.
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