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Dr. Bob is Robert Hsiung, MD,
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Posted by Jeroen on March 3, 2010, at 13:37:14
both increase QTc interval, Seroquel 12 ms and Sertindole (unkown)
taken them together appear to be safe...
Insomnia associated with chronic schizophrenia and after clozapine discontinuation represents a common, but mostly not predominant, complaint and often does not respond sufficiently to classical hypnotics. We report the case of a 46-year-old patient with schizophrenia who developed a rebound insomnia confirmed by polysomnography after discontinuation of long-term treatment with clozapine and changing to sertindole therapy. Zolpidem, zolpiclone and chloral hydrate only led to short-term improvement of subjective sleep quality. An add-on therapy with 300 mg quetiapine resulted in improved subjective quality of sleep regarding sleep latency and the number of nocturnal awakenings. The combination of the two neuroleptics did not lead to increased QTc intervals (normal QTc < 450 ms) or metabolic side effects. In conclusion, the combination of sertindole and quetiapine might be a safe and effective combination in therapy-refractory insomnia after clozapine discontinuation in schizophrenia.
First published on November 25, 2009
Posted by Phillipa on March 3, 2010, at 16:43:38
In reply to seroquel and sertindole together Safe? QTc, posted by Jeroen on March 3, 2010, at 13:37:14
Jeroen surprised chloral hydrate doesn't work as took it and it knocked me out. Love Phillipa
This is the end of the thread.
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