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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 13 of 13. This is the beginning of the thread.
Posted by Frustratedmama on March 23, 2010, at 20:37:16
Hi all,
So last night took first dose of Cymbalta- and another dose this AM (30 mg each).....I am supposed to take 30 mg in the AM for 2 more days with 50 mgs of Savella then switch to 60 mg of Cymbalta in the AM.....However, I feel SO MUCH BETTER just 24 hours later...and what I did was take 30 mg of Cymbalta last night and 30 this AM with 25 mg of Savella....
Could it be that taking 30 mg of CYmbalta with 25 mg of Savella twice daily would work for me?
Please share thoughts- or is it just because the Cymbalta helped to stop the withdrawal symptoms from the Pristiq...I hate to mess with what works and today was "normal" not too good and not pathetic for me.....want to capture and savor this feeling.....
How often do you all take cymbalta? once or twice a day?
and what about the combo? could it be a good one?
Posted by Phillipa on March 23, 2010, at 21:20:09
In reply to Low doses of Cymbalta and Savella- THOUGHTS?, posted by Frustratedmama on March 23, 2010, at 20:37:16
I don't know the normal dose of savella. But I thought cymbalta was once a day as time release? Anything is possible. I'd check with the doc as to the combo though make sure it's safe. Phillipa
Posted by Lou Pilder on March 23, 2010, at 21:55:17
In reply to Low doses of Cymbalta and Savella- THOUGHTS?, posted by Frustratedmama on March 23, 2010, at 20:37:16
> Hi all,
> So last night took first dose of Cymbalta- and another dose this AM (30 mg each).....I am supposed to take 30 mg in the AM for 2 more days with 50 mgs of Savella then switch to 60 mg of Cymbalta in the AM.....
>
> However, I feel SO MUCH BETTER just 24 hours later...and what I did was take 30 mg of Cymbalta last night and 30 this AM with 25 mg of Savella....
>
> Could it be that taking 30 mg of CYmbalta with 25 mg of Savella twice daily would work for me?
>
> Please share thoughts- or is it just because the Cymbalta helped to stop the withdrawal symptoms from the Pristiq...I hate to mess with what works and today was "normal" not too good and not pathetic for me.....want to capture and savor this feeling.....
>
> How often do you all take cymbalta? once or twice a day?
>
> and what about the combo? could it be a good one?FM,
You wrote,[...Hi all...the combo? (C)ould it be a good one?...]
There is a generally accepted fact that the combination of Cymbalta with Savella is risking the possibility of death by what is called now serotonin syndrome.
If you are still taking the amphetamine, (Adderall), it is generally accepted to be a potentiator of the other two drugs which could lead to death.
Now there could be issues with discontinuation at this time, if you are considering such, so assuming that these chemicals were prescribed to you, I think that a visit to the presciber of these chemicals to you could be helpful.
Lou
Posted by Lou Pilder on March 23, 2010, at 22:23:39
In reply to Lou's reply-psudunnekrow » Frustratedmama, posted by Lou Pilder on March 23, 2010, at 21:55:17
> > Hi all,
> > So last night took first dose of Cymbalta- and another dose this AM (30 mg each).....I am supposed to take 30 mg in the AM for 2 more days with 50 mgs of Savella then switch to 60 mg of Cymbalta in the AM.....
> >
> > However, I feel SO MUCH BETTER just 24 hours later...and what I did was take 30 mg of Cymbalta last night and 30 this AM with 25 mg of Savella....
> >
> > Could it be that taking 30 mg of CYmbalta with 25 mg of Savella twice daily would work for me?
> >
> > Please share thoughts- or is it just because the Cymbalta helped to stop the withdrawal symptoms from the Pristiq...I hate to mess with what works and today was "normal" not too good and not pathetic for me.....want to capture and savor this feeling.....
> >
> > How often do you all take cymbalta? once or twice a day?
> >
> > and what about the combo? could it be a good one?
>
> FM,
> You wrote,[...Hi all...the combo? (C)ould it be a good one?...]
> There is a generally accepted fact that the combination of Cymbalta with Savella is risking the possibility of death by what is called now serotonin syndrome.
> If you are still taking the amphetamine, (Adderall), it is generally accepted to be a potentiator of the other two drugs which could lead to death.
> Now there could be issues with discontinuation at this time, if you are considering such, so assuming that these chemicals were prescribed to you, I think that a visit to the presciber of these chemicals to you could be helpful.
> LouFriends,
I invite you to click on the link here and I think that there is educational material in the video that could possible be life-saving.
Lou
http://www.youtube.com/watch?v=egfXW74LMi8&feature=related
Posted by Phillipa on March 23, 2010, at 23:02:10
In reply to Low doses of Cymbalta and Savella- THOUGHTS?, posted by Frustratedmama on March 23, 2010, at 20:37:16
Hi could you babblemail me? Please?Phillipa
Posted by SLS on March 24, 2010, at 11:29:17
In reply to Lou's reply-pseighvayliph, posted by Lou Pilder on March 23, 2010, at 22:23:39
> Friends,
> I invite you to click on the link here and I think that there is educational material in the video that could possible be life-saving.
> Lou
> http://www.youtube.com/watch?v=egfXW74LMi8&feature=related
I think serotonin syndrome is a real risk when combining SRI drugs. However, I don't know with what frequency it occurs. Do you have any statistics regarding this?The practice of medicine in many different fields contains treatments that involve taking risks, some of which are fatal. The decision of whether or not to treat is not always an easy one. One must evaluate the risks versus benefits of each treatment. In some cases, it is a reasonable decision to use a treatment that carries with it the risk of death. Statistics are an important parameter in the decision making process.
- Scott
Posted by bleauberry on March 25, 2010, at 19:23:38
In reply to Low doses of Cymbalta and Savella- THOUGHTS?, posted by Frustratedmama on March 23, 2010, at 20:37:16
It's impossible to predict reactions to drug combos. The combo you describe sounds reasonable to me. Basically an ssri and snri together, both at low doses. Milnacipran is combined with ssris, so you aren't alone in that. And your response is not weird either. That's why they do combine them. I've never heard of it combined with cymbalta, but that means nothing.
Notice I didn't call cymbalta a snri. That's because its affinity for NE compared to SE is very weak. More of a marketing ploy than reality.
I especially like the low dose approach you have. I am of the opinion most patients are overdosed on supposedly normal doses, causing both undo side effects and undo negative physiological and genetic changes. Some people need a high dose or a supposedly normal dose, but I see too much risk in automatically assuming me or you or anyone else is in that camp until proven.
Posted by Lou Pilder on March 25, 2010, at 20:01:02
In reply to Re: Low doses of Cymbalta and Savella- THOUGHTS?, posted by bleauberry on March 25, 2010, at 19:23:38
> It's impossible to predict reactions to drug combos. The combo you describe sounds reasonable to me. Basically an ssri and snri together, both at low doses. Milnacipran is combined with ssris, so you aren't alone in that. And your response is not weird either. That's why they do combine them. I've never heard of it combined with cymbalta, but that means nothing.
>
> Notice I didn't call cymbalta a snri. That's because its affinity for NE compared to SE is very weak. More of a marketing ploy than reality.
>
> I especially like the low dose approach you have. I am of the opinion most patients are overdosed on supposedly normal doses, causing both undo side effects and undo negative physiological and genetic changes. Some people need a high dose or a supposedly normal dose, but I see too much risk in automatically assuming me or you or anyone else is in that camp until proven.bb,
You wrote,[...It's impossible to predict reactions to drug combos...reasonable to me...milnacapran is conbined with ssris...they do combine them...combined with cymbalta..means nothing...a marketing ploy...too much risk...]
I am unsure as to what you are wanting to mean in the above statement,[...It's impossible to predict reactions to drug combos...]. If you could post answers to the following, then I could have the opportunity to respond accordingly.
(Given)1:If a reaction to a drug combination is a possibility, then that does not mean that all will have that reaction.
(Given)2: If a reaction to a drug combination is a possiblity, then one could have that reaction.
In looking at your statement,[...It's impossible to predict reactions to drug combos...]and assumming the Givens above:
A. Would one of the Givens be what you are wanting to mean? If so, which one or both?
B. If not, what then is it that you are wanting to mean?
C. something else
Lou
Posted by Lou Pilder on March 25, 2010, at 20:23:44
In reply to Lou's request - imposi » bleauberry, posted by Lou Pilder on March 25, 2010, at 20:01:02
> > It's impossible to predict reactions to drug combos. The combo you describe sounds reasonable to me. Basically an ssri and snri together, both at low doses. Milnacipran is combined with ssris, so you aren't alone in that. And your response is not weird either. That's why they do combine them. I've never heard of it combined with cymbalta, but that means nothing.
> >
> > Notice I didn't call cymbalta a snri. That's because its affinity for NE compared to SE is very weak. More of a marketing ploy than reality.
> >
> > I especially like the low dose approach you have. I am of the opinion most patients are overdosed on supposedly normal doses, causing both undo side effects and undo negative physiological and genetic changes. Some people need a high dose or a supposedly normal dose, but I see too much risk in automatically assuming me or you or anyone else is in that camp until proven.
>
> bb,
> You wrote,[...It's impossible to predict reactions to drug combos...reasonable to me...milnacapran is conbined with ssris...they do combine them...combined with cymbalta..means nothing...a marketing ploy...too much risk...]
> I am unsure as to what you are wanting to mean in the above statement,[...It's impossible to predict reactions to drug combos...]. If you could post answers to the following, then I could have the opportunity to respond accordingly.
> (Given)1:If a reaction to a drug combination is a possibility, then that does not mean that all will have that reaction.
> (Given)2: If a reaction to a drug combination is a possiblity, then one could have that reaction.
> In looking at your statement,[...It's impossible to predict reactions to drug combos...]and assumming the Givens above:
> A. Would one of the Givens be what you are wanting to mean? If so, which one or both?
> B. If not, what then is it that you are wanting to mean?
> C. something else
> Loubb,
In,[...(Milnacapran) combined with cymbalta..means nothing...]
I am unsure as to what you are wanting to mean. If you could post answers to the following, then I could have the opportunity to respond accordingly.
A. does the combination have no possible reactions?
B. If there could be a reaction, is that reaction meaningless?
C. there are no published reports of an adverse reaction with them combined.
D. there is a published report that states that there is no possible way for there to be an adverse reaction with tem combined.
E. something else
Lou
Posted by Phillipa on March 25, 2010, at 21:14:50
In reply to Lou's request to bleauberry-menznuttin, posted by Lou Pilder on March 25, 2010, at 20:23:44
Lou I feel that since we're all individuals there is no way for anyone to predict how they will react to anything. Take the example of peanuts and someone has a peanut allergy unknown to them what could happen if they eat a peanut? Anaphylactic reaction? Maybe maybe not. Phillipa
Posted by Lou Pilder on March 25, 2010, at 21:51:04
In reply to Re: Lou's request to bleauberry-menznuttin » Lou Pilder, posted by Phillipa on March 25, 2010, at 21:14:50
> Lou I feel that since we're all individuals there is no way for anyone to predict how they will react to anything. Take the example of peanuts and someone has a peanut allergy unknown to them what could happen if they eat a peanut? Anaphylactic reaction? Maybe maybe not. Phillipa
Phillipa,
You wrote,[...there is no way for anyone to predict how they will react to anything...eat a peanut...].
I am unsure as to what you are wanting to mean. If you could post answerts to the following, then I could have the opportunity to respond accordingly.
A. Since a prediction can not be done, then it is safe to take two drugs that have been determined if combined could cause death
B. Since a prediction can not be done, then a warning does not have to be givin that taking a combination of drugs could kill you.
C. A warning means nothing since a prediction can not be done.
D. The fact that 34,000 people in the U.S. die each year from psychotropic drugs in some connection means that the warnings should be taken lightly. Now if there are 34,000 in just the U.S., that could mean about 300,000 thoughout the world each your so that in 10 years millions of people could die in some way from taking psychotropic drugs.
Scott wanted to know the math of this and the figure that I used here can be looked up. But if there is an increasing number of people each year of people taking these drugs, then maybe 10 million people will die from these drugs in 10 years. How many people die each year from peanuts?
E. something else
Lou
Posted by Frustratedmama on March 25, 2010, at 21:54:48
In reply to Re: Lou's request to bleauberry-menznuttin » Lou Pilder, posted by Phillipa on March 25, 2010, at 21:14:50
Hi everyone
So pdoc wanted to try just the Cymbalta at 60 mg and I wanted to try dosing twice a day (to see if I could ward off fatigue and other side effects) I am meeting with him next week but will say that so far the withdrawals are leaving and I am feeling better than I was. Still not great but better so I will take it.....I am considering adding 12.5 mg dose of Savella to the combination if I need to....but will try just the Cymbalta for now....Anyone know how long I should stick with just Cymbalta before it has "built up" in the system long enough to evaluate its efficacy on its own?Reminder I am still taking the Librium and adderall (both VERY low doses- 5 mg and 10 mg respectively)
Thanks
FM
Posted by Phillipa on March 25, 2010, at 22:08:04
In reply to Just Cymbalta- feel better- not great but better!, posted by Frustratedmama on March 25, 2010, at 21:54:48
So glad your doc agrees and your're doing well. Congrats Phillipa
This is the end of the thread.
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