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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 9 of 9. This is the beginning of the thread.
Posted by markwell on July 7, 2011, at 18:09:14
I've tried every imaginable a d to date without any success except a 10 yr run with paxil. My pdoc wants me to try oleptra next. Its an extended version of trazodone. I haven't heard of anyone having much luck with trazodone as an antidepressant. He acts like its a good ad. Anyone with major depression have any luck with trazodone? He wrote me the script but I haven't filled it yet. I hate trying a useless drug for 4 weeks then upping the dose for another 4 weeks and just continue with depression. Any thoughts on this? Really desperate!
Mark
Posted by linkadge on July 7, 2011, at 19:44:44
In reply to oleptra, posted by markwell on July 7, 2011, at 18:09:14
I actually like trazodone as an antidepressant. It had a good side effect profile for me and didn't leave me as apathetic as SSRIs.
Linkadge
Posted by jono_in_adelaide on July 7, 2011, at 23:56:17
In reply to Re: oleptra, posted by linkadge on July 7, 2011, at 19:44:44
You have know way of knowing wether it will work for YOU except by trying it - the fact that it did or didnt work for me isnt relevent.
I had failed several antidepressants, yet the drug reboxetine (which was criticised in the BMJ for its lack of efficiency) worked a miracle for me.
Try the trazadone and see what hapens, you have nothing to lose, and everything to gain
Posted by bleauberry on July 8, 2011, at 4:19:13
In reply to oleptra, posted by markwell on July 7, 2011, at 18:09:14
I feel sort of reluctant to put much faith in that med as well, but ya know, you just never know. I would have a lot more promise if the meds in question included one of the following: parnate, nardil, zoloft with nortriptyline, prozac with zyprexa, prozac with ritalin.
That said, when a whole variety of ADs fails to help someone, that to me is a clue they are barking up the wrong tree.....the problem is something else, not primarily the neurotransmitters. That's where you can start seeing real improvement with other things such as anti=inflammation herbs, pro-immune herbs, and anti-infection herbs. Your neurotransmitters might be perfectly capable of doing their job but are being comprised by a pathogenic influence. And thus not amount of increasing the neurotransmitters would help much....they're still comprised. That''s how I see these kinds of "treatment resistant" situations anyway. Pure unadulterated logic based on your history, so simple it evades us, says ADs might be the wrong approach in this case. Neurotransmitter deficiency theory is only one of multiple causes of mood disturbance, and unfortunately most patients and doctors completely ignore the other depression causing problems.
Case in point. Most lyme patients have depression. Most lyme patients do not find psych meds helpful. Most experience an antidepressant effect on antibiotics or herbs, but not ADs. That's because in their cases, the poop and pee of pathogenic organisms was causing the problem, not a lack of neurotransmitters.
Of course, none of it is simple. Much of it is guess work or detective work. As is much of medicine anyway. But clearly, when a bunch of ADs fail, I think it makes sense to expand the boundaries outside the psych toolbox.
Food for thought.
Posted by markwell on July 8, 2011, at 6:55:48
In reply to Re: oleptra, posted by bleauberry on July 8, 2011, at 4:19:13
I am also starting a heavy metal cleanse. I also have this whole bipolar diagnosis going on. I'm a mess.
Mark
Posted by zonked on July 8, 2011, at 10:20:23
In reply to Re: oleptra, posted by linkadge on July 7, 2011, at 19:44:44
Just curious, were you taking trazodone with anything else at the time? Did the hangover effect go away? I would think oleptra would mean "hangover xr" but apparently whomever is marketing it saw enough potential in it to develop an extended release version.
Posted by Phillipa on July 8, 2011, at 11:15:47
In reply to Re: oleptra » linkadge, posted by zonked on July 8, 2011, at 10:20:23
Got me cursious google search as it does seem a bit strange trazadone. Phillipa
Posted by floatingbridge on July 8, 2011, at 11:23:22
In reply to Re: oleptra » linkadge, posted by zonked on July 8, 2011, at 10:20:23
> Just curious, were you taking trazodone with anything else at the time? Did the hangover effect go away? I would think oleptra would mean "hangover xr" but apparently whomever is marketing it saw enough potential in it to develop an extended release version.
Hangover xr was my initial response, too. Now I'm curious.
Sorry you are in the soup right now, Mark. It'll get better.
Posted by mtdewcmu on July 8, 2011, at 19:45:04
In reply to Re: oleptra, posted by jono_in_adelaide on July 7, 2011, at 23:56:17
> Try the trazadone and see what hapens, you have nothing to lose, and everything to gain
Unfortunately, that's not quite true. There is something to lose, because every failed drug trial wastes a month or more of your time, with nothing to show for it except another crossed out name on your list. But, that's what we're forced to deal with.
This is the end of the thread.
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