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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 18 of 18. This is the beginning of the thread.
Posted by ethen on November 29, 2011, at 3:00:15
hi guys,i really need some help reguarding negative symptom of schizophrenia,its been three f*ck*ng years already,i m very sick and tired of those social withdrawal,anhedonia apathy and alogia...well,i dun wanna waste time i straight to the point,i want to listen to your experience on treatment of negative symptom and also which drug/med work??how long does it take??clozapine??latuda??amisulpride??stimulants(adderall,vyvnase or ritalin)??
and also what is the future treatment in this field??any new meds that is to be look up for??
a little about me:althought its been three years but i only started trying different meds 6 months ago as i m sick of living like this,meds i have tried include:risperdal,invega,geogon,mirtazapine,fluoxitient...
Posted by Phillipa on November 29, 2011, at 10:05:51
In reply to Schizophrenia Negative Symptoms---Help!, posted by ethen on November 29, 2011, at 3:00:15
I'm sorry you are having such a hard time have your tried clozaril? What is your age and what type of szhizophrenia do you have?Phillipa
Posted by ethen on November 29, 2011, at 10:14:55
In reply to Re: Schizophrenia Negative Symptoms---Help! » ethen, posted by Phillipa on November 29, 2011, at 10:05:51
> I'm sorry you are having such a hard time have your tried clozaril? What is your age and what type of szhizophrenia do you have?Phillipa
hey phillipa,i havent tried clozaril becoz of the blood test,do u have any experience on clozaril??does it help the symptoms i mentioned??no other method like ritalin/wellbutrin or latuda can help??
Posted by Bob12 on November 29, 2011, at 15:01:40
In reply to Re: Schizophrenia Negative Symptoms---Help!, posted by ethen on November 29, 2011, at 10:14:55
There is hope.
A novel medication is expected in 2013 which specifically addresses negative symptoms, while most current medications only deal primarily with positive symptoms.
RG1678
Glycine transporter-1 inhibitor
Roche
Schizophrenia
Phase III (NDA projected 2013)For more info:
Posted by Phillipa on November 29, 2011, at 18:50:31
In reply to Re: Schizophrenia Negative Symptoms---Help!, posted by ethen on November 29, 2011, at 10:14:55
I was a psych RN at one time and I watched those with Schizophrenia fail on many meds. When Clozaril came out most that went on it did very well. Yes the blood test is important. Were not any problems at the time with those taking it. Made them very tired at first but then voices, thoughts that were delusional, went away. I personally thought it was a great med. Phillipa
Posted by ethen on November 29, 2011, at 20:40:28
In reply to Schizophrenia Negative Symptoms---Help!, posted by ethen on November 29, 2011, at 3:00:15
rg1678 i already know the news,i m from malaysia,if its approve in USA in 2013(earliest),it will only be avilable in malaysia i think earliest 2014,thats another 3 years...
clozapine??is there anyway where we can skip the blood test and test if there is symptom for Agranulocytosis,then i stop the meds can we??
ritalin or latuda is no use??
Posted by Phillipa on November 29, 2011, at 22:46:10
In reply to Re: Schizophrenia Negative Symptoms---Help!, posted by ethen on November 29, 2011, at 20:40:28
Why do want to skip the blood test? Do you have fears of needles? Lots of people do. Phillipa
Posted by ethen on November 29, 2011, at 22:48:29
In reply to Re: Schizophrenia Negative Symptoms---Help! » ethen, posted by Phillipa on November 29, 2011, at 22:46:10
phillipa,what stopping me from going clozapine was the bloodtest,at one point of my life this year,i was so sad that i wanted to go for clozapine even if there was blooddraw,but now i m feeling abit scare of the blooddraw,i wonder if there is any place where i can try clozapine with othr method of testing agranulocytosis instead of using the bloodraw???
Posted by Phillipa on November 29, 2011, at 22:58:37
In reply to Re: Schizophrenia Negative Symptoms---Help!, posted by ethen on November 29, 2011, at 22:48:29
Ethan I understand but I just know you are a strong man and can get the blood draw. Secret is to not watch turn your head. It's really not painful. Would you try for me? If your doctor agrees and approves? Phillipa
Posted by ethen on November 29, 2011, at 23:01:12
In reply to Re: Schizophrenia Negative Symptoms---Help! » ethen, posted by Phillipa on November 29, 2011, at 22:58:37
phillipa give me a day or 2 to think,but what if it deosnt work??then woulden the blooddraw be wasteful??my main doctor disagree with clozapine,and doesnt want me to try...but when i visit a 2nd opinion,the doc said u should try clozapine,it can change your life dramatically...
phillipa,u had schizo??what meds ur on??
Posted by Phillipa on November 29, 2011, at 23:14:01
In reply to Re: Schizophrenia Negative Symptoms---Help!, posted by ethen on November 29, 2011, at 23:01:12
Ethan no don't have schizophrenia but I was a Nurse that took care of many schizophrenics and once they got back on their meds if they stopped them or switched to a different med clozaril being one I was so happy to see no more voices, no more evil spirits that spoke to some, or outside noises, and lots of fears disppeared. So you have two doctors? Makes it a bit harder what does your primary doctor suggest you take as a med? Please try not to fear needles though as you routinuely need blood tests for health reasons. Phillipa
Posted by ethen on November 29, 2011, at 23:18:10
In reply to Re: Schizophrenia Negative Symptoms---Help! » ethen, posted by Phillipa on November 29, 2011, at 23:14:01
ok,i do not have any positive symptom at all,i only had idea of reference and negative symptom...my primary doctor suggest i try different kind of meds,b4 going for that and also he now wants me to try pregnenolone...i been taking it for 2 weeks and also i would like to hear your opinion on ritalin/wellbutrin on neg symptom of schizo???
Posted by Phillipa on November 30, 2011, at 17:53:47
In reply to Re: Schizophrenia Negative Symptoms---Help!, posted by ethen on November 29, 2011, at 23:18:10
It's definitely shizophenia? If so I would think you would need some type of antipsychotic. Are you able to function, work or attend school? Phillipa
Posted by Zyprexa on November 30, 2011, at 19:29:34
In reply to Re: Schizophrenia Negative Symptoms---Help!, posted by ethen on November 29, 2011, at 23:18:10
The best drug I've taken has been Zyprexa, I've taken it for 13 years now. It brought me out of the house, where I would not talk to people and just have crazy thoughts. I taken risperdal which didn't help at all. I've taken geodon which just made me paranoid. Abilify which actualy made me worse. Zyprexa is the only one that got me out of hiding, and back to work, and socializing.
Posted by ethen on November 30, 2011, at 20:51:11
In reply to Re: Schizophrenia Negative Symptoms---Help! » ethen, posted by Zyprexa on November 30, 2011, at 19:29:34
i have tried zyprexa for 6 weeks,but it doesnt do anything...
i m probably schizophrenic,although i do work,but i coulden function at all socially,i m mute and also i m socially withdrawn...i read good review about amisulpride,what do u guys think about it??
Posted by Phillipa on November 30, 2011, at 22:00:27
In reply to Re: Schizophrenia Negative Symptoms---Help!, posted by ethen on November 30, 2011, at 20:51:11
I don't know the med. If you are working you are doing well. Phillipa
Posted by bleauberry on December 1, 2011, at 15:02:10
In reply to Schizophrenia Negative Symptoms---Help!, posted by ethen on November 29, 2011, at 3:00:15
Most of my negative symptoms were nicely improved when on amisulpride. I had experimented with 12.5mg doses, 25mg doses, and every-other-day doses. In any case, it was helpful for those specific symptoms except if the dose got too high they would get worse instead, just as with any antipsychotic.
I guess we all have unique biochemistries but for me anything in the realm of anhedonia/negative symptoms/social withdrawal...is tied to all of the neurotransmitters but primary to norepinephrine, secondarily to dopamine, and partially to serotonin. I'm sure other mechanisms and neuros are involved such as the endorphin system, cellular energy system, immune system and inflammation system, and maybe that's why rhodiola works good for these kinds of symptoms. Safe with meds too.
For several years my anhedonia and negative symptoms were kept at bay by a combination of prozac and adrafanil and zyprexa. The prozac/zyprexa took care of the depression pretty good, and then adrafinil knocked out most of the negative/anhedonia/lack of emotion stuff. These days rhodiola is my mainstay to help fend those symptoms off. Back then though I learned that whatever chemistry the stimulants worked on, it was somewhere within those same chemistries that anhedonia was directly related to.
For me ritalin was immediately helpful, while adderal was almost suicidal. Ritalin worked a lot better when on prozac. Probably one of the best for me is vicadin, which throws into question the whole ne/dopamine focus because vicadin is mostly endorphins/anti-inflammation. So there's no way to know. Ritalin and vicadin however have some wild ups an downs though so I only use that in emergencies once in a while.
Modafanil and/or adrafanil should be on the trial list also. No matter what, my opinion would be to include some experimentation with various doses of rhodiola with or without any meds. I just happen to think that of all the botanical medicines out there, rhodiola is probably the most significant for your specific symptoms.
I hope you might find something in this post useful. You do have some good options ahead of you, it's just a patient journey of trying various things and learning from the clues and the mistakes along the way.
> hi guys,i really need some help reguarding negative symptom of schizophrenia,its been three f*ck*ng years already,i m very sick and tired of those social withdrawal,anhedonia apathy and alogia...well,i dun wanna waste time i straight to the point,i want to listen to your experience on treatment of negative symptom and also which drug/med work??how long does it take??clozapine??latuda??amisulpride??stimulants(adderall,vyvnase or ritalin)??
>
> and also what is the future treatment in this field??any new meds that is to be look up for??
>
> a little about me:althought its been three years but i only started trying different meds 6 months ago as i m sick of living like this,meds i have tried include:risperdal,invega,geogon,mirtazapine,fluoxitient...
Posted by ethen on December 1, 2011, at 20:52:38
In reply to Re: Schizophrenia Negative Symptoms---Help!, posted by bleauberry on December 1, 2011, at 15:02:10
thx for ur reply,i would ask my doctor for those that u said...
This is the end of the thread.
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