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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 10 of 10. This is the beginning of the thread.
Posted by tensor on April 30, 2013, at 15:21:03
Anyone know the significance of the enzyme interaction between the two? Bupropion inhibits CYP2D6.
/tensor
Posted by Bob on May 1, 2013, at 0:06:37
In reply to bupropion + TCA, posted by tensor on April 30, 2013, at 15:21:03
> Anyone know the significance of the enzyme interaction between the two? Bupropion inhibits CYP2D6.
>
> /tensor
I'm not sure about the answer to your question, but are you considering taking such a combo?
Posted by tensor on May 2, 2013, at 17:17:08
In reply to Re: bupropion + TCA » tensor, posted by Bob on May 1, 2013, at 0:06:37
> I'm not sure about the answer to your question, but are you considering taking such a combo?
>Yes, I do. I'm partially responive to nortriptyline and mirtazpaine. Need to add something.
/tensor
Posted by SLS on May 2, 2013, at 21:32:19
In reply to Re: bupropion + TCA » Bob, posted by tensor on May 2, 2013, at 17:17:08
> > I'm not sure about the answer to your question, but are you considering taking such a combo?
> >
>
> Yes, I do. I'm partially responive to nortriptyline and mirtazpaine. Need to add something.
>
> /tensor
I think you should also consider adding Effexor/Pristiq.
- Scott
Posted by Bob on May 3, 2013, at 16:02:22
In reply to Re: bupropion + TCA » tensor, posted by SLS on May 2, 2013, at 21:32:19
> > > I'm not sure about the answer to your question, but are you considering taking such a combo?
> > >
> >
> > Yes, I do. I'm partially responive to nortriptyline and mirtazpaine. Need to add something.
> >
> > /tensor
>
>
> I think you should also consider adding Effexor/Pristiq.
>
>
> - Scott
There's no danger in adding Effexor/Pristiq to Nortriptyline?
Posted by tensor on May 4, 2013, at 8:07:44
In reply to Re: bupropion + TCA » tensor, posted by SLS on May 2, 2013, at 21:32:19
> > > I'm not sure about the answer to your question, but are you considering taking such a combo?
> > >
> >
> > Yes, I do. I'm partially responive to nortriptyline and mirtazpaine. Need to add something.
> >
> > /tensor
>
>
> I think you should also consider adding Effexor/Pristiq.
>
>
> - ScottThat's an idea that led me to think about Viibryd. What do you think about that combination?
Thanks,
tensor
Posted by SLS on May 4, 2013, at 8:31:12
In reply to Re: bupropion + TCA » SLS, posted by Bob on May 3, 2013, at 16:02:22
> > > > I'm not sure about the answer to your question, but are you considering taking such a combo?
> > > Yes, I do. I'm partially responive to nortriptyline and mirtazpaine. Need to add something.
> > I think you should also consider adding Effexor/Pristiq.
> There's no danger in adding Effexor/Pristiq to Nortriptyline?I have not encountered anything that would lead me to believe that there is an adverse interaction between these two drugs. I had no problem combining Effexor 300 mg/day with nortriptyline 75 mg/day. I did not add mirtazapine to this combination, but Effexor + mirtazapine has had a reputation for being a particularly good treatment for TRD.
- Scott
Posted by SLS on May 4, 2013, at 8:47:21
In reply to Re: bupropion + TCA » SLS, posted by tensor on May 4, 2013, at 8:07:44
> > > > I'm not sure about the answer to your question, but are you considering taking such a combo?
> > > Yes, I do. I'm partially responive to nortriptyline and mirtazpaine. Need to add something.
> > I think you should also consider adding Effexor/Pristiq.
> That's an idea that led me to think about Viibryd. What do you think about that combination?
I took Viibryd + nortriptyline without sequalae. It worked for about a week before pooping-out. Effexor has an established track record for efficacy. However, Viibryd seems to have a better side-effect profile. I experienced no adverse effects on sex-drive or function with Viibryd.If you are desperate, I think Effexor is a better choice. If you can afford to invest some time in performing multiple drug trials, Viibryd is probably a better choice.
- Scott
Posted by tensor on May 4, 2013, at 8:53:12
In reply to Re: bupropion + TCA » tensor, posted by SLS on May 4, 2013, at 8:47:21
> > > > > I'm not sure about the answer to your question, but are you considering taking such a combo?
>
> > > > Yes, I do. I'm partially responive to nortriptyline and mirtazpaine. Need to add something.
>
> > > I think you should also consider adding Effexor/Pristiq.
>
> > That's an idea that led me to think about Viibryd. What do you think about that combination?
>
> I took Viibryd + nortriptyline without sequalae. It worked for about a week before pooping-out. Effexor has an established track record for efficacy. However, Viibryd seems to have a better side-effect profile. I experienced no adverse effects on sex-drive or function with Viibryd.
>
> If you are desperate, I think Effexor is a better choice. If you can afford to invest some time in performing multiple drug trials, Viibryd is probably a better choice.
>
>
> - ScottI have never responded well to Effexor in the past. Viibryd is not yet available here so it has to be imported which is a little hassle. I have never tried duloxetine, maybe I should?
That is, replace nortrip with duloxetine.thanks again,
tensor
Posted by SLS on May 5, 2013, at 12:21:20
In reply to Re: bupropion + TCA » SLS, posted by tensor on May 4, 2013, at 8:53:12
> I have never responded well to Effexor in the past. Viibryd is not yet available here so it has to be imported which is a little hassle. I have never tried duloxetine, maybe I should?
Some people do well with Cymbalta who failed to respond adequately to Effexor.
> That is, replace nortrip with duloxetine.
I was thinking that these two drugs should be combined.
- Scott
This is the end of the thread.
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