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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by g_g_g_unit on September 22, 2013, at 5:37:51
sorry to drone on, but I increased my dose to 100mg a day a little over a week ago and am still feeling very anxious, irritable and am having trouble sleeping.
I feel stubborn and stupid clinging on, as I did the same thing with memantine for 3 pointless months, but I guess I can't face the prospect of it not working.
is there any sense in thinking this stuff might pass?
I'm going to ask my doctor for a Prazosin script tomorrow to hopefully help sleep/take the edge off, so I can at least hold out longer, but I feel so unbearably frustrated, angry and distraught over this whole thing.
Posted by LouisianaSportsman on October 2, 2013, at 20:32:03
In reply to still feeling bad on Riluzole, posted by g_g_g_unit on September 22, 2013, at 5:37:51
What made you want to try riluzole? What is your current regimen?
Your post worries me as I am about to try to riluzole therapy.
Posted by g_g_g_unit on October 2, 2013, at 21:00:14
In reply to Re: still feeling bad on Riluzole, posted by LouisianaSportsman on October 2, 2013, at 20:32:03
I wasn't on anything else when I tried Riluzole.
I wouldn't worry -- it seems to work really well in studies. I'm just cursed.
Posted by SLS on October 4, 2013, at 6:22:56
In reply to still feeling bad on Riluzole, posted by g_g_g_unit on September 22, 2013, at 5:37:51
> sorry to drone on, but I increased my dose to 100mg a day a little over a week ago and am still feeling very anxious, irritable and am having trouble sleeping.
>
> I feel stubborn and stupid clinging on, as I did the same thing with memantine for 3 pointless months, but I guess I can't face the prospect of it not working.
>
> is there any sense in thinking this stuff might pass?
>
> I'm going to ask my doctor for a Prazosin script tomorrow to hopefully help sleep/take the edge off, so I can at least hold out longer, but I feel so unbearably frustrated, angry and distraught over this whole thing.For me, it seems that a combination of Minocycline + Lamictal has modulated excessive glutamate activity. I also take Abilify.
I was very disappointed by riluzole. It didn't help at all. However, one cannot deduce from this that glutamate dysfunction is not contributing to depression and anxiety.
Have you ever tried Navane (thiothixine) or Phenergan (promethazine) for your anxiety?
Prazosin is an interesting choice. Recent studies use 20 - 30 mg/day in divided doses. Despite the use of these higher dosages, one must nonetheless begin treatment using a single 1.0 mg dose given at night and follow up 2.0 - 3.0 mg. Even at this low dosage, temporary dizziness often occurs, so a gradual titration is recommended.
Is there any history of trauma?
- Scott
Posted by g_g_g_unit on October 4, 2013, at 8:01:11
In reply to Re: still feeling bad on Riluzole » g_g_g_unit, posted by SLS on October 4, 2013, at 6:22:56
>
> For me, it seems that a combination of Minocycline + Lamictal has modulated excessive glutamate activity. I also take Abilify.My Minocycline trial was cut short by Riluzole, but I still have a box lying around. I'm not that impressed by the results in OCD, though.
>
> I was very disappointed by riluzole. It didn't help at all. However, one cannot deduce from this that glutamate dysfunction is not contributing to depression and anxiety.I know, it's pretty heartbreaking, especially since the data for anxiety/depression seems so promising.
>
> Have you ever tried Navane (thiothixine) or Phenergan (promethazine) for your anxiety?To be honest, I get akathisia on tiny doses of AAP, so am not foaming at the mouth to try an older antipsychotic. I can't imagine the subjective effects would be too pleasant either.
>
> Prazosin is an interesting choice. Recent studies use 20 - 30 mg/day in divided doses. Despite the use of these higher dosages, one must nonetheless begin treatment using a single 1.0 mg dose given at night and follow up 2.0 - 3.0 mg. Even at this low dosage, temporary dizziness often occurs, so a gradual titration is recommended.
>
My GP vetoed the Prazosin idea because of low BP.> Is there any history of trauma?
>Not officially, though the last 5 years of living with an anxiety disorder could be described as traumatic.
I read that you said Prazosin could provide AD benefits in patients with childhood abuse .. my mother is narcissistic and a lot of hurtful recollections surfaced in therapy, though I've never been diagnosed with an official traumatic complex.
This is the end of the thread.
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