![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by hello123 on January 8, 2015, at 17:54:49
this is a bit of a technical question, but ive read that increasing Norepinephrine can have a downstream effect of increasing Dopamine. How does this increase in Dopamine actually occur? ive tried finding an article describing it, but cant find anything on Pubmed.
ive had a feeling NRI's have an indirect effect on Dopamine after my experience with a few SNRI Antidepressants, but my experience felt more like a severe *decrease* in Dopamine instead of an increase. After about 3 days on SNRI's ive experienced a severe decrease in ability to feel pleasure thats very different in the numbing effect an increase in Serotonin has. But the decrease in pleasure ive experienced from SNRI's has caused me to stop the med after the length of time that is typical for a full med trial. And my pdoc prescribed Strattera for Depression today and im hoping i will be able to give this a full trial. Does anyone have exoerience with meds that increase Norepinephrine causing worse Depression the first few weeks, with mood improvements after that?
Posted by linkadge on January 8, 2015, at 19:58:47
In reply to Stratteras increase in NE = increased DA?, posted by hello123 on January 8, 2015, at 17:54:49
From what I understand, the prefrontal cortex lacks dopamine transporters. Instead, the norepinephrine transporter works to uptake dopamine in the prefrontal cortex. So, in the prefrontal cortex, a NRI can increase dopamine levels.
Linkadge
Posted by rjlockhart37 on January 8, 2015, at 20:56:17
In reply to Re: Stratteras increase in NE = increased DA?, posted by linkadge on January 8, 2015, at 19:58:47
yea....but it's indirectly ... NE makes you more alert, improves attention, and when your alert and have more attention your more likely to do things that require motivation, and pleasure.....then that's kinda how dopamine get's envolved through activities that require dopamine to think, and get things done
have to search more on the physics of how NE links to dopamine through chemical interaction
Posted by burial on January 9, 2015, at 8:28:12
In reply to Re: Stratteras increase in NE = increased DA?, posted by rjlockhart37 on January 8, 2015, at 20:56:17
yes it's quite correct. Norepinephrine neurons also utilize dopamine, so when the reuptake is blocked, not only norepinephrine but also dopamine is boosted in synapses.
Posted by Phillipa on January 9, 2015, at 17:59:11
In reply to Re: Stratteras increase in NE = increased DA?, posted by burial on January 9, 2015, at 8:28:12
How does cymbalta help pain since has norepenephrine?
Posted by ed_uk2010 on January 10, 2015, at 0:55:53
In reply to Re: Stratteras increase in NE = increased DA?, posted by Phillipa on January 9, 2015, at 17:59:11
> How does cymbalta help pain since has norepenephrine?
Various drugs which act as norepinephine reuptake inhibitors, like Cymbalta and tricylic antidepressants are useful in chronic pain. The might act to reduce the transmission of pain signals in the spinal cord, but there are likely to be multiple mechanisms of action.
Posted by hello123 on January 10, 2015, at 23:05:00
In reply to Re: Stratteras increase in NE = increased DA? » Phillipa, posted by ed_uk2010 on January 10, 2015, at 0:55:53
ive figured feeling better emotionally is what helps chronic pain. from my experience, when my depression is intense, just the pain from bumping into something is more intollerable than when im feeling okay emotionally. When im feeling good, the pain from it doesnt bother me near as much.
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.