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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 8 of 8. This is the beginning of the thread.
Posted by Christ_empowered on January 25, 2019, at 23:28:53
the new prescriber mentioned lowering the abilify a whole, whole lot, then switching to a low dose of latuda.
for some reason, antidepressants are a big NO! I asked about amoxapine, and even that was a big NO!
so, somehow, ive gone from schizophrenia/schizoaffective prone to depression to in your face Bipolar I...
and I don't think I've had anything remotely resembling "mania" in years.
the other chit chat was about adding another 'mood stabilizer,' which apparently means they'd like to treat my moods as if they were grand mal seizures...
oh man. i made pleasant convo and stood my ground, i now have a prn gabapentin Rx because...I don't know why, honestly...'stay calm!,' I guess.
but, seriously: abilify vs latuda. can anyone fill me in on why, exactly, a low dose of latuda might be better than a low(ish) dose of abilify? i know they're both new drugs, but...what about eps, etc.? the -big- selling point for Abilify, with me personally, is that the EPS was less severe than anything else (tremor), and then when I started doing Orthomolecular...
even that subsided, thank goodness.
ok. thank you all, in advance. :-)
Posted by Lamdage22 on January 26, 2019, at 9:02:55
In reply to abilify vs latuda, posted by Christ_empowered on January 25, 2019, at 23:28:53
Hmm i would say its highly individual how people respond to those. I get akathisia from both. I thought you are on 20mg Abilify?
Posted by Christ_empowered on January 26, 2019, at 10:46:53
In reply to Re: abilify vs latuda, posted by Lamdage22 on January 26, 2019, at 9:02:55
hi. i am taking 20mgs/abilify daily. this lady is new, so i was asking about reducing the abilify. my question was: "how low can you go?" and she says "I dunno...5mgs, maybe all the way off...," which on the one hand is fabulous news (I guess?), because then I should have a lower TD risk and if I can get off a neuroleptic then...awesome. however...
I think it raises questions about diagnosis and who decides what, exactly, a given individual's "problems" = in DSM/ICD -speak.
I don't know what to do, really. Long term, I think I might be better off -not- taking a neuroleptic, at least not daily. My diagnosis ranges from "Schizoaffective, manic type" (which was once "good outcome Schizophrenia," back in the day) to "Bipolar I, prone to psychosis" which...?
What kind of got to me was the talk of mania. "Oh, you have obsessive traits. well, you know, we can't really give you an antidepressant...you might go manic...," which...might turn out to be a good maneuver, long term (AD drugs do seem to somehow cause more erratic moods, plus apathy...wellbutrin didn't, but it also wouldn't have worked without the Abilify on board...), but...again: who is doing the diagnosing, here? Based on...what info?
so there you go. I don't really want to try a switch to Latuda, honestly. I think I'd be better off just seeing about going as low as I can, as slowly as possible, on the Abilify...and maybe I'll be tranq-free in a year or so (?).
Posted by SLS on January 26, 2019, at 21:21:17
In reply to Re: abilify vs latuda, posted by Lamdage22 on January 26, 2019, at 9:02:55
> Hmm i would say its highly individual how people respond to those. I get akathisia from both. I thought you are on 20mg Abilify?
Quick question: Have you ever tried Luvox (fluvoxamine)?
- Scott
Posted by rjlockhart37 on January 27, 2019, at 1:26:10
In reply to Re: abilify vs latuda » Lamdage22, posted by SLS on January 26, 2019, at 21:21:17
zyprexa gave me bad bad akensia, but that was when i first started it, and actually ... this is a funny story, i was put on 30mgs of olanzapine in a psych, it helped me sleep very well, and i was strangely calm and slightly sedated, but after a while i started having to move, like bump your foot and shake leg when your sitting down, restless sympotoms, then afte that i started having jerking episodes, i was at home and all of sudden i jerked while i was eat a steak, and started jerking while ... this was major involentary jerks.....and that was because zyprexa was blocking dopamine, but for wierd reason i can take 30mg of olanzipine and be fine, actually function the next day and feel stable, but i adjusted to it. If it was withdrawn it would be hell
abilify is dopamine agonist, as well as anti psychosis, i've heard abilify is slightly stimulating because of the D2 agonist, or something
Posted by Lamdage22 on January 27, 2019, at 23:51:09
In reply to Re: abilify vs latuda, posted by Christ_empowered on January 26, 2019, at 10:46:53
Check out the website www.survivingantidepressants.org
I have tried Luvox for a week but i was heavily sedated because of the cyp3a4 inhibition. I would rather try other Cyp3a4 inhibitors like curcume or berberine. But i dont know if i can do this with the drugs i take which are cyp3a4 substrates!
Posted by SLS on January 28, 2019, at 10:39:13
In reply to Re: abilify vs latuda, posted by Lamdage22 on January 27, 2019, at 23:51:09
It is not unusual for people to have sedation as a side effect with Luvox. I don't know how long it lasts or if it lessens in magnitude over time. I mentioned Luvox because it exerts the opposite effects on sigma receptors compared to Zoloft. Luvox is a potent sigma-1 agonist. Zoloft is an antagonist. This is why Zoloft produces akathisia while Luvox actually treats it. Luvox is also being used to treat psychosis. I'm just wondering if sigma receptors are somehow involved in your condition. It's a long-shot, I guess.
Some studies indicate that Luvox is better for treating psychotic depression than are the other SSRIs. You might want to research the degree to which Luvox produces sedation and how long it lasts.
- Scott
Posted by Lamdage22 on January 29, 2019, at 5:39:43
In reply to Re: abilify vs latuda » Lamdage22, posted by SLS on January 28, 2019, at 10:39:13
Hi Scott,
thanks for your thoughts. Zoloft actually almost miraculously lifted the fog of depression at a VERY low dosage. However Akathisia was stubborn.
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