![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 10 of 10. This is the beginning of the thread.
Posted by mtom on July 13, 2019, at 13:42:04
Is it because newer AD's are actually more effective with fewer side effects? Or is it more related to marketing - e.g. Prozac being one of the first SSRI's to go off patent, Pharma companies pushing "newer" still patented drugs as "better", etc.
Posted by Christ_empowered on July 13, 2019, at 16:35:56
In reply to Why is Prozac not prescribed much any more?, posted by mtom on July 13, 2019, at 13:42:04
im prescribed prozac. so far, so good.
Posted by vbs on July 13, 2019, at 22:30:32
In reply to Re: Why is Prozac not prescribed much any more?, posted by Christ_empowered on July 13, 2019, at 16:35:56
Prozac works the best for me too. I was previously taking Trintellix.
Posted by Hordak on July 16, 2019, at 17:28:38
In reply to Why is Prozac not prescribed much any more?, posted by mtom on July 13, 2019, at 13:42:04
> Is it because newer AD's are actually more effective with fewer side effects? Or is it more related to marketing - e.g. Prozac being one of the first SSRI's to go off patent, Pharma companies pushing "newer" still patented drugs as "better", etc.
Because many interactions via CYP450.
Posted by mtom on July 16, 2019, at 19:12:56
In reply to Re: Why is Prozac not prescribed much any more?, posted by Hordak on July 16, 2019, at 17:28:38
> Because many interactions via CYP450.
Thanks Hordak, I do understand about interactions. However this applies to all the AD's as they are all metabolized by enzymes of the P450 system, many by CYP2D6, some also by other CYP enzymes. As are many other medications (I had Genetic Testing for medications done last year and have researched this topic a lot as I believe it is applicable to adverse reactions and efficacy).
Since writing the first post, I am reading that Prozac is, in fact, still widely prescribed (including 2 previous posters to this thread). This surprised me as I don't personally know anyone who is taking it - although this is a fairly limited number. I suspect others I know take an AD, but just don't talk about it.
People who have mentioned their current AD's to me are taking Celexa (citalopram), Cipralex/Lexapro (escitalopram), Bupropion (Wellbutrin), Venlafaxine (Effexor), Sertraline (Zoloft), and someone who recently started Trintellix (Vortioxetine) - the latter having switched from something else due to adverse effects (don't know what he was taking previously).
Posted by mtom on July 16, 2019, at 19:15:04
In reply to Re: Why is Prozac not prescribed much any more?, posted by vbs on July 13, 2019, at 22:30:32
> Prozac works the best for me too. I was previously taking Trintellix.
Hi vbs. I know someone who recently started on Trintellix because of adverse effects to his previous antidepressant (don't know what that was).
What types of issues did you have on Trintellex that have improved with Prozac?
Posted by Hordak on July 16, 2019, at 20:54:27
In reply to Re: Why is Prozac not prescribed much any more? » Hordak, posted by mtom on July 16, 2019, at 19:12:56
> > Because many interactions via CYP450.
>
> Thanks Hordak, I do understand about interactions. However this applies to all the AD's as they are all metabolized by enzymes of the P450 system, many by CYP2D6, some also by other CYP enzymes. As are many other medications (I had Genetic Testing for medications done last year and have researched this topic a lot as I believe it is applicable to adverse reactions and efficacy).
>
> Since writing the first post, I am reading that Prozac is, in fact, still widely prescribed (including 2 previous posters to this thread). This surprised me as I don't personally know anyone who is taking it - although this is a fairly limited number. I suspect others I know take an AD, but just don't talk about it.
>
> People who have mentioned their current AD's to me are taking Celexa (citalopram), Cipralex/Lexapro (escitalopram), Bupropion (Wellbutrin), Venlafaxine (Effexor), Sertraline (Zoloft), and someone who recently started Trintellix (Vortioxetine) - the latter having switched from something else due to adverse effects (don't know what he was taking previously).
>
>
>
>What matters is the degree of interaction...
Posted by TH on July 17, 2019, at 2:45:38
In reply to Re: Why is Prozac not prescribed much any more?, posted by Hordak on July 16, 2019, at 20:54:27
Fluoxetine is still very much a first-line antidepressant here in New Zealand, I believe.
Posted by Hordak on July 28, 2019, at 15:53:00
In reply to Re: Why is Prozac not prescribed much any more?, posted by TH on July 17, 2019, at 2:45:38
> Fluoxetine is still very much a first-line antidepressant here in New Zealand, I believe.
First line treatments in the western hemisphere are: Sertraline & Escitalopram.
Posted by Ruuudy on July 28, 2019, at 16:27:41
In reply to Re: Why is Prozac not prescribed much any more? » TH, posted by Hordak on July 28, 2019, at 15:53:00
I've been a Prozac/fluoxetine consumer since 1990 - nearly 30 years.
'Bout the only thing it helps with now is keeping the hair from growing on my elbows,,, but as I age, I think that hair growth has been diverted from my elbows to my ears!
In other words, I don't think the fluoxetine is doing much for me anymore. Time for a change.
I've been doing the Spravato treatments for 6 weeks - not sure it's doing much-to-anything either.Thinking of asking for a switchup to Trintellix or Pristiq.
Rudy
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.