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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by Hordak on July 28, 2019, at 16:45:35
"Revitalizing monoamine oxidase inhibitors: a call for action"
Gillman is getting serious and starts to bring "heavy ordnance" into play! Nice! What is he up to?
Posted by linkadge on July 28, 2019, at 17:43:12
In reply to 'Revitalizing monoamine oxidase inhibitors', posted by Hordak on July 28, 2019, at 16:45:35
It's a shame that the medical community is turning from their use. After all, depression can be a life threatening illness. In one pill, MAOIs have a very broad spectrum mechanism.
In my own personal research into mood disorders, there is (far) more evidence of dysregulated monoamine oxidase, than there is for a dysregulated serotonin reuptake system.
Linakdge
Posted by Hordak on July 28, 2019, at 18:50:10
In reply to Re: 'Revitalizing monoamine oxidase inhibitors', posted by linkadge on July 28, 2019, at 17:43:12
> In my own personal research into mood disorders, there is (far) more evidence of dysregulated monoamine oxidase, than there is for a dysregulated serotonin reuptake system.
>
> LinakdgeThat is interesting! Any articles or papers? :=D
Posted by linkadge on July 29, 2019, at 15:32:57
In reply to Re: 'Revitalizing monoamine oxidase inhibitors', posted by Hordak on July 28, 2019, at 18:50:10
Hey,
Well, doing some research on serotonin transporters in depression reveals that (if anything) the serotonin transporter is already lower than normal in depression. However, many studies I have read suggest that, at least in the social stress model of depression, there is an upregulation of monoamine oxidase A, and subsequent drop in all three monoamines. Nothing is completely conclusive, but I have seen quite a few more studies suggesting that MAO-A is higher in mood disorders than studies suggesting that SERT is higher (in fact, as mentioned, in most cases it is lower).
What this suggests to me, is that MAO-A may be more of a central dysregulation than monoamine transporters. However, we don't have brain selective MAO-A inhibitors, and hence the drugs we use create the tyramine effect.
Here is one study, but there are others.
https://www.ncbi.nlm.nih.gov/pubmed/25502632Linkadge
Posted by Lamdage22 on July 30, 2019, at 0:12:38
In reply to Re: 'Revitalizing monoamine oxidase inhibitors', posted by linkadge on July 29, 2019, at 15:32:57
Well, MAOI didn't help me because I became (pre)psychotic.
This is the end of the thread.
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