Psycho-Babble Medication Thread 1117231

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Rat doses

Posted by NKP on October 11, 2021, at 2:26:34

In laboratory studies, do the doses that are used on rats correspond to those that are used on humans?

For example, I read a study in which venlafaxine was administered to rats at doses of 5 mg/kg body weight and 10 mg/kg body weight. In humans, these would be enormous doses (in a 70 kg / 150 lbs person, you're looking at around 350 mg and 700 mg respectively), but perhaps rats metabolize these drugs differently. Would these doses correspond to typical low and high doses in humans?

Re: Rat doses

Posted by undopaminergic on October 11, 2021, at 9:50:56

In reply to Rat doses, posted by NKP on October 11, 2021, at 2:26:34

> In laboratory studies, do the doses that are used on rats correspond to those that are used on humans?
>
> For example, I read a study in which venlafaxine was administered to rats at doses of 5 mg/kg body weight and 10 mg/kg body weight. In humans, these would be enormous doses (in a 70 kg / 150 lbs person, you're looking at around 350 mg and 700 mg respectively), but perhaps rats metabolize these drugs differently. Would these doses correspond to typical low and high doses in humans?
>

Doses used in rodents (or other animals) often do not correspond directly to human doses. Usually, the rodent doses are higher, sometimes much higher.

-undopaminergic

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