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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 12 of 12. This is the beginning of the thread.
Posted by iforgotmypassword on November 9, 2021, at 21:51:30
Posted by Lamdage22 on November 10, 2021, at 3:01:25
In reply to NonD2AP Ulotaront Effective for Neg Sx in Sz, posted by iforgotmypassword on November 9, 2021, at 21:51:30
Thanks for sharing. This might not make you tired and fat?
Posted by undopaminergic on November 10, 2021, at 8:13:20
In reply to Re: NonD2AP Ulotaront Effective for Neg Sx in Sz, posted by Lamdage22 on November 10, 2021, at 3:01:25
> Thanks for sharing. This might not make you tired and fat?
>
> https://en.wikipedia.org/wiki/UlotarontThere is another non dopamine antagonist antipsychotic called KarXT:
https://www.google.com/search?q=karxt-undopaminergic
Posted by linkadge on November 10, 2021, at 15:34:53
In reply to KarXT, posted by undopaminergic on November 10, 2021, at 8:13:20
Very interesting. This is a completely different target. TAAR1 agonists may be useful in multiple neuropsychiatric disorders.
Linkadge
Posted by Lamdage22 on November 10, 2021, at 20:29:59
In reply to Re: KarXT, posted by linkadge on November 10, 2021, at 15:34:53
That is cool. Anything not making you slow and fat would be a huge improvement.
Posted by Lamdage22 on November 11, 2021, at 1:49:22
In reply to Re: KarXT, posted by Lamdage22 on November 10, 2021, at 20:29:59
I might actually feel younger with 40 than with 30, if they make progress better treatment. It is not over yet. No wonder that so many reject treatment with those reward blocking drugs. I don't. I have learned my lesson. But I'm not exactly happy with it.
Posted by undopaminergic on November 11, 2021, at 3:25:01
In reply to Re: KarXT, posted by linkadge on November 10, 2021, at 15:34:53
> Very interesting. This is a completely different target. TAAR1 agonists may be useful in multiple neuropsychiatric disorders.
>
> LinkadgeYes, but KarXT works on the cholinergic system.
-undopaminergic
Posted by linkadge on November 11, 2021, at 17:54:29
In reply to Re: KarXT, posted by undopaminergic on November 11, 2021, at 3:25:01
I was just commenting on the link provided:
"Ulotaront, an agonist at the trace amine-associated receptor 1 (TAAR1) and 5-hydroxytryptamine type 1A (5-HT1A) receptors, received breakthrough therapy designation from the US Food and Drug Administration. The agonist does not bind to D2 or 5-HT2A."
Linkadge
Posted by linkadge on November 11, 2021, at 17:56:07
In reply to Re: KarXT, posted by undopaminergic on November 11, 2021, at 3:25:01
I don't think I would try KarXT. The net cholinergic effect would be central, but this (in my opinion) could lead to depression.
Linkadge
Posted by undopaminergic on November 11, 2021, at 23:00:49
In reply to Re: KarXT » undopaminergic, posted by linkadge on November 11, 2021, at 17:56:07
> I don't think I would try KarXT. The net cholinergic effect would be central, but this (in my opinion) could lead to depression.
>
> LinkadgeI agree that it might have a depressive effect, but I would still try it, if for no other reason to see if I'm right.
-undopaminergic
Posted by SLS on November 12, 2021, at 5:05:29
In reply to Re: KarXT » undopaminergic, posted by linkadge on November 11, 2021, at 17:56:07
Hi, Linkadge.
> I don't think I would try KarXT. The net cholinergic effect would be central, but this (in my opinion) could lead to depression.
>
> Linkadge
This was my concern as well.
- Scott
Posted by SLS on November 12, 2021, at 5:07:40
In reply to Re: KarXT » linkadge, posted by undopaminergic on November 11, 2021, at 23:00:49
> > I don't think I would try KarXT. The net cholinergic effect would be central, but this (in my opinion) could lead to depression.
> >
> > Linkadge> I agree that it might have a depressive effect, but I would still try it, if for no other reason to see if I'm right.
>
> -undopaminergic
<smile>
- Scott
This is the end of the thread.
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