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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by KaraS on November 24, 2004, at 15:13:02
I know that this citation is not exactly the New England Journal of Medicine but I would be interested in hearing your views on this article anyway. The author claims that the tests done which led to the determination that picolinate is unsafe (damages DNA) were not valid.
Posted by Larry Hoover on November 24, 2004, at 15:44:25
In reply to Picolinate revisited - safe after all?, posted by KaraS on November 24, 2004, at 15:13:02
> I know that this citation is not exactly the New England Journal of Medicine but I would be interested in hearing your views on this article anyway. The author claims that the tests done which led to the determination that picolinate is unsafe (damages DNA) were not valid.
>
> http://www.ivillage.com/diet/experts/wlcoach/articles/0,,165535_76679,00.html?arrivalSA=1&cobrandRef=0&arrival_freqCap=1&pba=adid=12386369Well, I don't think the issue is settled. I could list a number of studies showing genetic damage in living organisms, i.e. in vivo, not just the in vitro tests that this man dismisses. The fact is, the in vitro tests showed damage from chromium picolinate which was not seen with an equal concentration of chromium chloride. You just can't dismiss that, out of hand.
"Comparative studies of chromium(III) picolinate and niacin-bound chromium(III), two popular dietary supplements, reveal that chromium(III) picolinate produces significantly more oxidative stress and DNA damage. Studies have implicated the toxicity of chromium picolinate in renal impairment, skin blisters and pustules, anemia, hemolysis, tissue edema, liver dysfunction; neuronal cell injury, impaired cognitive, perceptual and motor activity; enhanced production of hydroxyl radicals, chromosomal aberration, depletion of antioxidant enzymes, and DNA damage. Recently, chromium picolinate has been shown to be mutagenic and picolinic acid moiety appears to be responsible as studies show that picolinic acid alone is clastogenic. Niacin-bound chromium(III) has been demonstrated to be more bioavailable and efficacious and no toxicity has been reported."
I'm not so worried that I won't use up the chromium picolinate I have on hand, but I won't buy any more.....until it is shown to be safe.
Lar
Posted by jasmineneroli on November 24, 2004, at 16:15:33
In reply to Re: Picolinate revisited - safe after all? » KaraS, posted by Larry Hoover on November 24, 2004, at 15:44:25
I've been taking Picolinate for about 5 -6 years! (Wherever possible, I've used the nicotinate - or niacin bound - chromium version, instead, but it's hard to get here).
It has without doubt, helped my blood sugar issues, whereas plain old chromium GTF does nothing. (That's what I started with years ago, and immediately noticed a difference with picolinate).
However, maybe I can blame my decreased cognitive functioning and possible slow hepatic enzyme metabolization to this supplement??!!!
I'm just getting more and more confused, and more anxious about supplements every day!
When my current batch of picolinate runs out, I will try my utmost to find polynicotinate!
I was ready to start trying SAM-e too, but I'm not sure anymore............
Jas-in-turmoil
Posted by KaraS on November 25, 2004, at 1:32:09
In reply to Re: Picolinate revisited - safe after all? » KaraS, posted by Larry Hoover on November 24, 2004, at 15:44:25
> > I know that this citation is not exactly the New England Journal of Medicine but I would be interested in hearing your views on this article anyway. The author claims that the tests done which led to the determination that picolinate is unsafe (damages DNA) were not valid.
> >
> > http://www.ivillage.com/diet/experts/wlcoach/articles/0,,165535_76679,00.html?arrivalSA=1&cobrandRef=0&arrival_freqCap=1&pba=adid=12386369
>
> Well, I don't think the issue is settled. I could list a number of studies showing genetic damage in living organisms, i.e. in vivo, not just the in vitro tests that this man dismisses. The fact is, the in vitro tests showed damage from chromium picolinate which was not seen with an equal concentration of chromium chloride. You just can't dismiss that, out of hand.
>
> From:
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12324196
>
> "Comparative studies of chromium(III) picolinate and niacin-bound chromium(III), two popular dietary supplements, reveal that chromium(III) picolinate produces significantly more oxidative stress and DNA damage. Studies have implicated the toxicity of chromium picolinate in renal impairment, skin blisters and pustules, anemia, hemolysis, tissue edema, liver dysfunction; neuronal cell injury, impaired cognitive, perceptual and motor activity; enhanced production of hydroxyl radicals, chromosomal aberration, depletion of antioxidant enzymes, and DNA damage. Recently, chromium picolinate has been shown to be mutagenic and picolinic acid moiety appears to be responsible as studies show that picolinic acid alone is clastogenic. Niacin-bound chromium(III) has been demonstrated to be more bioavailable and efficacious and no toxicity has been reported."
>
> I'm not so worried that I won't use up the chromium picolinate I have on hand, but I won't buy any more.....until it is shown to be safe.
>
> Lar
>Thanks Lar,
I definitely won't buy anymore of it. I just noticed that the zinc I used to take was partially in picolinate form also. I'll have to get something else for that too.K
Posted by KaraS on November 25, 2004, at 2:31:50
In reply to Re: Picolinate revisited - safe after all? » Larry Hoover, posted by jasmineneroli on November 24, 2004, at 16:15:33
> I've been taking Picolinate for about 5 -6 years! (Wherever possible, I've used the nicotinate - or niacin bound - chromium version, instead, but it's hard to get here).
> It has without doubt, helped my blood sugar issues, whereas plain old chromium GTF does nothing. (That's what I started with years ago, and immediately noticed a difference with picolinate).
> However, maybe I can blame my decreased cognitive functioning and possible slow hepatic enzyme metabolization to this supplement??!!!
> I'm just getting more and more confused, and more anxious about supplements every day!
> When my current batch of picolinate runs out, I will try my utmost to find polynicotinate!
> I was ready to start trying SAM-e too, but I'm not sure anymore............
> Jas-in-turmoil
I know how you feel exactly. Lately I've been feeling like nothing is safe. There are so many things to consider when you purchase and then use supplements. It's overwhelming sometimes.
This is the end of the thread.
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