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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 4 of 4. This is the beginning of the thread.
Posted by TomV on February 1, 2005, at 10:43:55
I really hate FDA medication, and have never had great responses to most meds. I take SAMe, 1400 mgs per day, but now that's starting to poop out. The literature says 1200 to 1600 mgs per day is the normal range for a serious depression. Has anyone gone higher than 1600?
Tom
Posted by Chris O on February 1, 2005, at 11:42:09
In reply to How much SAMe do you take?, posted by TomV on February 1, 2005, at 10:43:55
I took SAM-e on and off for about a year at doses probably up to 2000mg/day. Like you, it just did not seem to do much for me after a while, even at higher doses. It "pooped out" and I didn't notice much difference from 400mg to 2000mg. It was all the same. Seems like every non-pharmaceutical supplement I take is like that. SAM-e was one of the most effective for me though, although it was only like a very weak SSRI, kind of like a weak Wellbutrin, in my opinion.
Chris
Posted by TomV on February 1, 2005, at 12:26:50
In reply to Re: How much SAMe do you take? » TomV, posted by Chris O on February 1, 2005, at 11:42:09
Hello Chris,
That's very interesting. A Pdoc I saw years ago told me about one of his patients that took 2000 mg/day. At that time SAMe had just come on the US market and was pretty expensive. I had a good response taking 400 mg/day right away, but eventually I began ramping up due to poop out. I eventually gave up on taking SAMe as a front line AD due to the cost. Well, since then, there are ways to get SAMe significantly cheaper, but I'm still running into the same problem (poop out). I'm wondering if I should go all the way to 2000 mg/day. Have you ever had success taking SAMe with an AD?
Tom
I took SAM-e on and off for about a year at doses probably up to 2000mg/day. Like you, it just did not seem to do much for me after a while, even at higher doses. It "pooped out" and I didn't notice much difference from 400mg to 2000mg. It was all the same. Seems like every non-pharmaceutical supplement I take is like that. SAM-e was one of the most effective for me though, although it was only like a very weak SSRI, kind of like a weak Wellbutrin, in my opinion.
> Chris
Posted by Chris O on February 1, 2005, at 16:53:35
In reply to Re: How much SAMe do you take?, posted by TomV on February 1, 2005, at 12:26:50
Tom:
I have never combined SAM-e with an SSRI, or other anti-depressant, anti-convulsant, anti-anxiety pharmaceutical. I only took it alone, or combined with fish oil, which was like, nothing. Fish oil has never done anything for me either, and I've taken it in relatively large doses. I don't know how SAM-e would interact with SSRIs, but since it seems pretty weak to me to begin with, probably wouldn't have a huge impact. To me, SAM-e is like an extremely mild Wellbutrin, so it would seem to go better with some of the more "sedating" SSRIs, Celexa, Lexapro, etc. My primary condition is GAD and OCD. Have you had any luck with any other supplements for your condition?
All the best,
ChrisHello Chris,
>
> That's very interesting. A Pdoc I saw years ago told me about one of his patients that took 2000 mg/day. At that time SAMe had just come on the US market and was pretty expensive. I had a good response taking 400 mg/day right away, but eventually I began ramping up due to poop out. I eventually gave up on taking SAMe as a front line AD due to the cost. Well, since then, there are ways to get SAMe significantly cheaper, but I'm still running into the same problem (poop out). I'm wondering if I should go all the way to 2000 mg/day. Have you ever had success taking SAMe with an AD?
>
> Tom
This is the end of the thread.
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