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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 9 of 9. This is the beginning of the thread.
Posted by Chairman_MAO on May 2, 2005, at 9:44:51
In reply to Re: Social Phobia, anxiety 5HT2 receptors, posted by linkadge on April 30, 2005, at 22:25:09
I am working with a cutting-edge supplement company to design an anxiolytic/antidepressant formula that many on this board will be interested in. What's going to be in it is mostly beyond this discussion, but I make mention of it because it's going to include gastrodin, a component monomer of Gastrodia Elata et blume extract. It is an SSADH inhibitor, thereby slowing the breakdown of GABA. I am also going to include a GABA-T inhibitor, natural BZD [partial] agonist, Ca2+ blocker, natural DA antagonist preferential for autoreceptors, and a few other standard things like kava (for Na+ and extra Ca2+ blockade). I will also probably include a small amount of phenibut for GABA-B agonism and to increase BZD binding. Then, I'm going to combine some key aspects of that formula with natural MAO-A and MAO-B inhibitors, as well as maybe a natural imidazoline receptor agonist and natural pde4 inhibitor to produce a Nardil-like herbal product. Not bad, huh? It is my sincere hope that at least one person here will find relief in my work.
Posted by KaraS on May 2, 2005, at 22:07:34
In reply to Re: Social Phobia ... my new anxiolytic formula » linkadge, posted by Chairman_MAO on May 2, 2005, at 9:44:51
> I am working with a cutting-edge supplement company to design an anxiolytic/antidepressant formula that many on this board will be interested in. What's going to be in it is mostly beyond this discussion, but I make mention of it because it's going to include gastrodin, a component monomer of Gastrodia Elata et blume extract. It is an SSADH inhibitor, thereby slowing the breakdown of GABA. I am also going to include a GABA-T inhibitor, natural BZD [partial] agonist, Ca2+ blocker, natural DA antagonist preferential for autoreceptors, and a few other standard things like kava (for Na+ and extra Ca2+ blockade). I will also probably include a small amount of phenibut for GABA-B agonism and to increase BZD binding. Then, I'm going to combine some key aspects of that formula with natural MAO-A and MAO-B inhibitors, as well as maybe a natural imidazoline receptor agonist and natural pde4 inhibitor to produce a Nardil-like herbal product. Not bad, huh? It is my sincere hope that at least one person here will find relief in my work.
Wow, sounds very ambitious. Will you tell us at some point where the product will be sold? I know you've mentioned working with a company previously. Is it that same company?K
Posted by Phillipa on May 3, 2005, at 18:02:20
In reply to Re: Social Phobia ... my new anxiolytic formula, posted by KaraS on May 2, 2005, at 22:07:34
What do you do? Are you a chemist? Fondly, Phillipa
Posted by Chairman_MAO on May 3, 2005, at 20:31:00
In reply to Re: Social Phobia ... my new anxiolytic formula, posted by KaraS on May 2, 2005, at 22:07:34
No, this company is a lot cooler. ;)
I'm really not sure when exactly it will be out, but probably in 2-3 months.
Posted by Phillipa on May 3, 2005, at 20:38:11
In reply to Re: Social Phobia ... my new anxiolytic formula » KaraS, posted by Chairman_MAO on May 3, 2005, at 20:31:00
Chairman_MAO, my husband wants to know what the company name is as he is interested in buying some stock. If this not a Rx med then it doesn't need FDA approval right? You can Babble me the info as he is really interested. Thanks, Phillipa
Posted by Declan on May 4, 2005, at 17:27:38
In reply to Re: Social Phobia ... my new anxiolytic formula » linkadge, posted by Chairman_MAO on May 2, 2005, at 9:44:51
Get cracking. And market it in Australia so I don't have to worry about customs.
Declan
Posted by Chairman_MAO on May 5, 2005, at 19:06:40
In reply to Re: Social Phobia ... my new anxiolytic formula, posted by Phillipa on May 3, 2005, at 20:38:11
Heh, the company is not publicly traded ;)
I do not want to get anyone's hopes up excessively high, but like I said, we hope to have this out in around three months. It's going to include all "natural" ingredients such that it could be marketed as a "dietary supplement".
I'm glad that linkadge posted to this board that Fo-Ti root is an MAO-B inhibitor. Actually, the MAO-B inhibitng component of it is emodin, which I knew about, but did not know was in fo-ti. So now I likely have a more reliable MAO-B inhibitor than the one I was going to use, isatin. Isatin is the body's own MAO-B inhibitor. Levels of isatin are increased during stress, and it can cause anxiety (but then again, so can deprenyl et al). But I feel better using a compound such as emodin which is not endogenous in this circumstance, as I simply could not find enough literature about the other effects of isatin in man. So, you can thank him for that if I manage to get the "antidepressant" formula to market.
My other project besides OTC anxiolytic/antidepressant is an OTC product for mitigating opioid tolerance and dependence. This is not nearly as far along as the other one, though, but I'm passionate about it, and so is the guy that hired me, so hopefully we can get it to market eventually. I don't expect anything magical, but I'm fairly confident that I can get something out there that could afford those dependent upon opioid medication at least 25, probably 50% potentiation of their medication and significant attenuation of dependence. I don't want to go into details, as I'm a starving (well, not really, but you get the idea, heh) college student with mental illness (treatment-resistant dysthymia/"double depression" and moderate social phobia/agoraphobia), so I could use some funds from the profit of such an invention. I promise, though, that if either of these formulas don't end up making it into something commercial, I will release my work on this board so that everyone can benefit from it.
The quality and efficacy of most herbal/natural/otherwise OTC products on the market--at least the psychoactive ones--by and large is severely impoverished. I was tired of simply complaining about it and observing it, so I decided to take all of my self-taught knowledge (much of which I gained while sequestered in my room, depressed, simultaneously too afraid and strangely disinterested to go out and socialize, heh) and change that. Then, hopefully those who cannot get the right meds--which, IMHO, are many or even most people with mental illness--can have a worthy alternative to try.
Cheers!
Posted by Declan on May 5, 2005, at 21:25:59
In reply to Re: Social Phobia ... my new anxiolytic formula » Phillipa, posted by Chairman_MAO on May 5, 2005, at 19:06:40
I read something in a herb book about Withania slowing down the development of opiate tolerance in rats. (Tested them on some kind of hotplate) Didn't work for me, well its hard to tell, isn't it?
Declan
Posted by Chairman_MAO on May 6, 2005, at 11:15:49
In reply to Re: Social Phobia ... my new anxiolytic formula, posted by Declan on May 5, 2005, at 21:25:59
Order the drug proglumide (Milid) from overseas. That has a clinically proven tolerance-reversing effect. If you combined that with an NMDA antagonist, you'd probably get a better response. Or, even more preferably, combine the proglumide with ultra-low-dose naltrexone therapy.
You can find refs to all of that on google. Dealing with opioid tolerance is not as hard as people make it out to be. The powers that be simply don't want it to be done, because then the only justification for not handing out narcotics would be bunk. After all, they are physiologically safer than the alternative medications, and often more effective!
This is the end of the thread.
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