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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 10 of 10. This is the beginning of the thread.
Posted by Divergent_reality on May 23, 2005, at 22:55:45
Is it safe to take Dexedrine and St. John's Wort together?
Posted by Declan on May 24, 2005, at 0:44:18
In reply to Dexedrine+St. John's Wort???, posted by Divergent_reality on May 23, 2005, at 22:55:45
I'd do it at the drop of a hat. Can't see why not.
Declan
Posted by Larry Hoover on May 24, 2005, at 8:23:13
In reply to Dexedrine+St. John's Wort???, posted by Divergent_reality on May 23, 2005, at 22:55:45
> Is it safe to take Dexedrine and St. John's Wort together?
I don't see why not, although I have a mild concern. One of the compounds in SJW is a general reuptake inhibitor. It inhibits all neurotransmitter reuptake. So, taking it with a drug that preferentially modulates a lone neurotransmitter *may* potentiate the effects of that drug to some extent.
Lar
Posted by Divergent_reality on May 24, 2005, at 10:47:44
In reply to Re: Dexedrine+St. John's Wort??? » Divergent_reality, posted by Larry Hoover on May 24, 2005, at 8:23:13
Would that mean that I should start out with a low dose of Dexedrine, 5mg., and than go from there if necessary, because I might find that 5mg. could or would be like taking 10 mg.? Also, does Dexedrine deplete serotonin?
Thanks,
Di
Posted by Larry Hoover on May 24, 2005, at 11:26:49
In reply to Re: Dexedrine+St. John's Wort??? » Larry Hoover, posted by Divergent_reality on May 24, 2005, at 10:47:44
> Would that mean that I should start out with a low dose of Dexedrine, 5mg., and than go from there if necessary, because I might find that 5mg. could or would be like taking 10 mg.? Also, does Dexedrine deplete serotonin?
>
> Thanks,
>
> DiI take it you're already taking a stable dose of SJW, and you wish to add in dexedrine?
I wouldn't want to speculate on the size of a possible interaction. What is important is that you are aware that there might be one. Prudence would indeed suggest that you start at a lower dose of dex, and work up. That is simply the best way to combine any two substances. Get stable on the first one, and add the second one incrementally, noting how it feels *for you*.
I do not believe you have any concerns with respect to serotonin.
Lar
Posted by Divergent_reality on May 24, 2005, at 12:08:56
In reply to Re: Dexedrine+St. John's Wort??? » Divergent_reality, posted by Larry Hoover on May 24, 2005, at 11:26:49
Thank you very much, Lar. I'll post my reactions just in case anyone else might be interested.
Di
Posted by Larry Hoover on May 24, 2005, at 12:24:18
In reply to Re: Dexedrine+St. John's Wort??? » Larry Hoover, posted by Divergent_reality on May 24, 2005, at 12:08:56
> Thank you very much, Lar. I'll post my reactions just in case anyone else might be interested.
>
> DiEgg-cellent. ;-)
Lar
Posted by divergent_reality on June 11, 2005, at 12:43:41
In reply to Re: Dexedrine+St. John's Wort??? » Divergent_reality, posted by Larry Hoover on May 24, 2005, at 12:24:18
Hi,
I have had to cutdown on my intake of SJW to one 300 mg. capsule @ night. I currently take 5 mg. of dexedrine @ around 10 am. and again @ around 2 pm. I tried not taking the SJW at all, but it didn't "feel" right either. I then tried 2 SJW @ night and that was disastrous. I felt more depressed, anxious, parinoid, tired and cried most of the day.
About 3 years ago I was taking Adderall and doing very well until they changed the inactive ingredients which caused me to break out in large hives that lasted for weeks. Before that I was on Wellbutrin and doing quite well until six weeks later when I broke out in hives also. Since then I have been searching for something that would help relieve my depression.
Any thoughts as to why I'm reacting negatively to an increase in the SJW dosage would be much appreciated.
Thanks,
Di
Posted by Vaughan on April 9, 2013, at 22:07:47
In reply to Re: Dexedrine+St. John's Wort??? » Larry Hoover, posted by divergent_reality on June 11, 2005, at 12:43:41
Was there any updates on this? Wanted to know how you went with this mix as my Phyc has suggested we try it but I've heard others try it and have had a really bad outcome from it, from my view though St Johns wort does a better job than any other anti depressant I've tried (and I've tried them all over 2 years before reaching this) for my depression and anxiety yet my ADD is basically a killer and career stopper.
Last time I tried Dex I got severe anxiety (not seretonin syndrome etc just racing thoughts which I kind of get without being on St Johns Wort) so wondering if the 2 would work well hand in hand. Phyc again wants to give it a go but wanted to get some feedback first.
Posted by novelagent on April 19, 2013, at 17:50:01
In reply to Re: Dexedrine+St. John's Wort???, posted by Vaughan on April 9, 2013, at 22:07:47
try emsam, combined with PEA, which has a synergistic effect. it worked for my depression after everything else failed.
as for combining dexedrine, try tyrosine. It's a precursor to dopamine, so there's a synergistic effect. magnesium and zinc work well for optimizing concentration of dexedrine as well.
dexedrine can make you more anxious, more stressed out, and more hard on yourself at higher doses. keep a low dose, no more than 30 mg, 40mg/day tops.
This is the end of the thread.
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