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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 4 of 4. This is the beginning of the thread.
Posted by sdb on May 17, 2005, at 1:07:50
Dear Lar!
You seem to be very knowledgable (as toxicologist(?)) in this forum, do you have any idea to split capsules in a way that it does not change pharmacokinetics?
Kind regards
sdb
Posted by sdb on May 20, 2005, at 4:17:21
In reply to Split capsules to Larry Hoover, posted by sdb on May 17, 2005, at 1:07:50
Thank you anyway Larry,
Phillipa gave me a hint how to do it. I have not checked yet.
regards
sdb
Posted by Larry Hoover on May 24, 2005, at 22:34:32
In reply to Split capsules to Larry Hoover, posted by sdb on May 17, 2005, at 1:07:50
> Dear Lar!
>
> You seem to be very knowledgable (as toxicologist(?)) in this forum, do you have any idea to split capsules in a way that it does not change pharmacokinetics?
>
> Kind regards
>
> sdbSorry, I still haven't had time to read the whole board. I did some at the bottom, and at the top, but the middle......
Capsules are generally used to serve one of two purposes. The first, and most common, is simply to get yucky tasting stuff past the tongue quickly, without exposing those receptors to the yuck. The second thing is to avoid the gag reflex, that comes from certain textures (as well as some tastes).
The gelatin coating of the capsule dissolves in very short order, in the stomach. So, the capsule itself has no effect on pharmacokinetics.
If by "splitting a capsule" you mean taking the contents of one capsule and putting it into two separate ones, then you change nothing at all. The pharmacokinetics will be consistent with the dose, and the frequency of dosing.
I hope that answers your question. If not, help me to understand what you need to figure out.
Lar
Posted by sdb on May 29, 2005, at 4:50:31
In reply to Re: Split capsules to Larry Hoover » sdb, posted by Larry Hoover on May 24, 2005, at 22:34:32
Hi Lar,
Thanks for your advice. But honestly the capsules have influence of pharmacokinetics, it depends about differences how fast you want to get effects and it depends about the substance itself sometimes.
Kind regards
sdb
This is the end of the thread.
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