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Dr. Bob is Robert Hsiung, MD,
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Posted by MM on October 27, 2005, at 19:32:10
http://www.biopsychiatry.com/glutamategaba.htm
And possibly point me in the right direction for finding out more? Serotonin and Norepinephrine (in my extreme-lay person opinion) are not what I want to target...Dopamine might be (welbutrin seems to work ok at 75mg, but any higher and I dunno..) and I think GABA could be something good for me too. I know that's REALLY simplified reasoning but I can barely think anymore so understanding neurology seems just a TAD out of reach.
Thanks for any help.
Posted by nolvas on October 27, 2005, at 22:14:46
In reply to Can someone explain this to me?, posted by MM on October 27, 2005, at 19:32:10
Glutamate is a salt or ester of Glutamic Acid. Glutamic Acid is a precursor for the manufacture of Gamma-Aminobutyric-Acid (GABA).
There are are various drugs and supplements that either increase GABA levels in the brain or increase it's effectiveness.Pharmaceutical Drugs >
Baclofen mimics the function of GABA (by functioning as a GABAb Receptor Agonist) - it occupies and stimulates GABAb Receptors similarly to GABA.
Barbiturates inhibit the body's reuptake of GABA, thereby depressing the Central Nervous System.
Gabapentin increases the synthesis of GABA in the Brain.Librium and Diazepam (Valium) inhibit the body's reuptake of GABA, thereby allowing its tranquilizing effects to be potentiated.
Vigabatrin increases the Brain’s levels of GABA.Smart Drugs >
Gamma-Hydroxybutyric Acid (GHB) is both a precursor for and a metabolite of GABA.
Pyroglutamate may stimulate the release of Gamma Aminobutyric Acid (GABA) in the Brain).Vitamins >
Alpha-Glycerylphosphorylcholine (a specific form of Choline) may increase the release of GABA.
Inositol is a necessary cofactor for many of the functions of GABA.
Vitamin B3 (Niacinamide form) may enhance the function of GABA. [more info]
Vitamin B6 is an essential cofactor for the conversion of Glutamic Acid to GABA.Herbs >
Ginkgo biloba may increase GABA levels in the Hippocampus of the Brain.
Saint John’s Wort may inhibit the reuptake of GABA (which leads to increased GABA levels and increased GABA activity). This action occurs from the Hyperforin content of Saint John’s Wort.
Valerian may inhibit the breakdown of GABA.Amino Acids >
GABA is formed within the Brain from Glutamic Acid (via Glutamine).
Theanine may increase GABA levels in the Brain.Hormones >
Melatonin (when used as a supplement) may increase the concentration of GABA in the Hypothalamus by up to 50%.
Triiodothyronine (T3) is required for the optimal production and function of GABA.Minerals >
Zinc is a cofactor for the production of GABA.
Nervous System >
GABA prevents Nerve Impulses associated with Anxiety from reaching the motor centers of the Brain (by filling the Benzodiazepine Receptors of the Brain).
Supplemental GABA may improve the condition of Attention Deficit/Hyperactivity Disorder (ADHD) patients.
GABA binds to the body's Benzodiazepine Receptors - it opens Chloride channels within (and thereby inhibits) Benzodiazepine Receptors.
GABA sedates the Central Nervous System (by filling the Benzodiazepine Receptors in the Brain).
GABA concentrates in the Cerebral Cortex.
GABA may help to prevent Convulsions (via its role as an inhibitory Neurotransmitter).Adequate Brain GABA levels are required to prevent the Seizures associated with Epilepsy.
GABA concentrates in the Hypothalamus.
GABA decreases the activity of Neurons in the Brain, preventing them from over-firing (by filling the Benzodiazepine Receptors of the Brain).Panic Disorder patients have been demonstrated to have low Brain levels of GABA, indicating that supplemental GABA (or its precursors) may be useful for the treatment of Panic Disorder.
Supplemental GABA (350 - 3,000 mg per night administered sublingually) may facilitate Sleep:
Supplemental GABA (350 - 3,000 mg per night) may alleviate Insomnia.
GABA may prevent Nerve Impulses associated with Stress from reaching the motor centers of the Brain (by filling the Benzodiazepine Receptors of the Brain).WARNING : I don't endorse that you take any of these substances without prior research. I've provided this information just for research purposes.
Posted by MM on October 27, 2005, at 23:25:06
In reply to Re: Can someone explain this to me?, posted by nolvas on October 27, 2005, at 22:14:46
Thank you nolvas. Lots of stuff I didn't know about! When I take my Klonopin and Trileptal at night, I find I can think and concentrate better (or it seems like it). I'll look into those some of those.
This is the end of the thread.
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