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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by RedSoxFan79 on November 21, 2005, at 20:05:16
Biol Psychiatry. 2005 Aug 9
Department of Pharmacology (LH, BT), University of Colorado Health Sciences Center, Denver, Colorado
BACKGROUND: Adenylyl cyclase (AC) is an enzyme that can regulate the physiologic effects of numerous drugs and hormones through the production of cyclic adenosine-3',5'-monophosphate (cAMP). Some studies suggest that certain measures of AC activity are lower among depressed subjects. We examined the relationship between various measures of AC activity and major depression, taking into account potential confounders, such as drug use and gender. METHODS: We assessed the relationship between platelet levels of AC activity and lifetime diagnosis of major depression among 1481 participants (226 subjects with a history of major depression and 1255 control subjects) in an international, cross-sectional study initiated by the World Health Organization and the International Society on Biomedical Research on Alcoholism. RESULTS: After accounting for recent drug use, subjects with a history of major depression had markedly lower mean levels for all measures of platelet AC activity compared with control subjects. The adjusted odds ratios for major depression comparing the bottom to the top quartile of AC activity were 2.69 for basal (95% confidence interval [CI] 1.30-5.56), 3.72 for cesium fluoride-stimulated (95% CI 1.54-8.98), 6.20 for forskolin-stimulated (95% CI 2.04-18.80), and 2.20 for Gpp(NH)p-stimulated (95% CI 1.03-4.70). CONCLUSIONS: Subjects with major depression have lower platelet AC activity levels, and this relationship is dramatically attenuated by various types of drug use.
Posted by TenMan on November 21, 2005, at 21:24:06
In reply to Adenylyl cyclase activity linked to depression, posted by RedSoxFan79 on November 21, 2005, at 20:05:16
I have been taking forskolin which increases cAMP concentrations for a while now and can attest to it's antidepressant activity. I feel much better after a dose.
Posted by Declan on November 22, 2005, at 4:17:31
In reply to Re: Adenylyl cyclase activity linked to depression, posted by TenMan on November 21, 2005, at 21:24:06
Hi
So forskolin has an AD effect? Coleus Forskoli is an interesting herb (with the most terrible taste).
Hydergine is supposed to elevate C-AMP and I found it had a distinct and definate AD effect in sublingual doses > 9mg/d. Most people say it's completely innefective.
"The Zone" bloke said that forskolin was the best herb to take
Declan
Posted by linkadge on November 22, 2005, at 16:19:50
In reply to Re: Adenylyl cyclase activity linked to depression, posted by Declan on November 22, 2005, at 4:17:31
doesn't caffiene work through this mechanism ?
Linakdge
Posted by Declan on November 22, 2005, at 18:35:53
In reply to Re: Adenylyl cyclase activity linked to depression, posted by linkadge on November 22, 2005, at 16:19:50
I've heard that
This is the end of the thread.
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